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Tibor Bakács Pál Czanik Ian Kimber Gábor Ringwald Michael Moore Erzsébet Ábrahám 《Cancer immunology, immunotherapy : CII》1984,16(3):170-174
We have analysed the influence of human malignant, inflammatory and infectious disease on the capacity of peripheral lymphocytes to mediate antibody-dependent haemolysis. The application of an enzyme-like kinetic model for measurement of maximal cytotoxic function has permitted reproducible and sensitive determinations of the K-cell function. The results show that malignant disease is associated with enhancement of ADCC capacity. 相似文献
674.
Sai-Wen Tang Aurelie Ducroux Kuan-Teh Jeang Christine Neuveut 《Journal of biomedical science》2012,19(1):1-11
Autophagy is a protein degradative process important for normal cellular metabolism. It is apparently used also by cells to eliminate invading pathogens. Interestingly, many pathogens have learned to subvert the cell’s autophagic process. Here, we review the interactions between viruses and cells in regards to cellular autophagy. Using findings from hepatitis B virus and human retroviruses, HIV-1 and HTLV-1, we discuss mechanisms used by viruses to usurp cellular autophagy in ways that benefit viral replication. 相似文献
675.
The present study explored whether the use of group medication with antibiotics in a Danish pig herd was reduced after vaccination
of the pigs against proliferative enteropathy (PE) caused by Lawsonia intracellularis. 7900 pigs originating from a single commercial sow herd were vaccinated against L. intracellularis, whereas 7756 pigs were kept as non-vaccinated controls. The pigs were included batch-wise in the study with every second
batch being vaccinated. In the vaccinated batches, the consumption of oxytetracykline to treat PE was reduced by 79%, with
a significantly lower number of pigs being treated (P < 0.0001). Vaccination also resulted in a highly significant improvement of average daily weight gain (+ 46 g/day; P = 9.55 × 10-31) and carcase weight (+ 1.25 kg; P = 4.54 × 10-05) as well as a shortened fattening period (-8 days; P = 2.01 × 10-45). 相似文献
676.
Karina Acevedo-Whitehouse Laura Petetti Padraig Duignan Aurelie Castinel 《Proceedings. Biological sciences / The Royal Society》2009,276(1672):3523-3529
Hookworms are intestinal blood-feeding nematodes that parasitize and cause high levels of mortality in a wide range of mammals, including otariid pinnipeds. Recently, an empirical study showed that inbreeding (assessed by individual measures of multi-locus heterozygosity) is associated with hookworm-related mortality of California sea lions. If inbreeding increases susceptibility to hookworms, effects would expectedly be stronger in small, fragmented populations. We tested this assumption in the New Zealand sea lion, a threatened otariid that has low levels of genetic variability and high hookworm infection rates. Using a panel of 22 microsatellites, we found that average allelic diversity (5.9) and mean heterozygosity (0.72) were higher than expected for a small population with restricted breeding, and we found no evidence of an association between genetic variability and hookworm resistance. However, similar to what was observed for the California sea lion, homozygosity at a single locus explained the occurrence of anaemia and thrombocytopenia in hookworm-infected pups (generalized linear model, F = 11.81, p < 0.001) and the effect was apparently driven by a particular allele (odds ratio = 34.95%; CI: 7.12–162.41; p < 0.00001). Our study offers further evidence that these haematophagus parasites exert selective pressure on otariid blood-clotting processes. 相似文献
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C. Dieperink ‡ B. D. Bak † L.-F. Pedersen † M. I. Pedersen † S. Pedersen † 《Journal of fish biology》2002,61(3):848-852
Radio-tagged smolts of Atlantic salmon Salmo salar and sea trout Salmo trutta were predated heavily by sea birds after crossing the saline limit in the estuary of the River Skjern, Denmark. Most predation took place within the first 9 h after estuarine entry. The field data do not contradict the hypothesis of maladaptive anti-predatory behaviour. 相似文献