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191.
Paulo Roque Obreli-Neto Leonardo Régis Leira Pereira Camilo Molino Guidoni André de Oliveira Baldoni Srecko Marusic Divaldo Pereira de Lyra-Júnior Kelsen Luis de Almeida Ana Claudia Montolezi Pazete Janaina Dutra do Nascimento Mitja Kos Edmarlon Girotto Roberto Kenji Nakamura Cuman 《PloS one》2013,8(12)
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193.
Kátia Regina da Silva Roberto Costa Elizabeth Sartori Crevelari Marianna Sobral Lacerda Caio Marcos de Moraes Albertini Martino Martinelli Filho José Eduardo Santana Jo?o Ricardo Nickenig Vissoci Ricardo Pietrobon Jacson V. Barros 《PloS one》2013,8(7)
Background
The ability to apply standard and interoperable solutions for implementing and managing medical registries as well as aggregate, reproduce, and access data sets from legacy formats and platforms to advanced standard formats and operating systems are crucial for both clinical healthcare and biomedical research settings.Purpose
Our study describes a reproducible, highly scalable, standard framework for a device registry implementation addressing both local data quality components and global linking problems.Methods and Results
We developed a device registry framework involving the following steps: (1) Data standards definition and representation of the research workflow, (2) Development of electronic case report forms using REDCap (Research Electronic Data Capture), (3) Data collection according to the clinical research workflow and, (4) Data augmentation by enriching the registry database with local electronic health records, governmental database and linked open data collections, (5) Data quality control and (6) Data dissemination through the registry Web site. Our registry adopted all applicable standardized data elements proposed by American College Cardiology / American Heart Association Clinical Data Standards, as well as variables derived from cardiac devices randomized trials and Clinical Data Interchange Standards Consortium. Local interoperability was performed between REDCap and data derived from Electronic Health Record system. The original data set was also augmented by incorporating the reimbursed values paid by the Brazilian government during a hospitalization for pacemaker implantation. By linking our registry to the open data collection repository Linked Clinical Trials (LinkedCT) we found 130 clinical trials which are potentially correlated with our pacemaker registry.Conclusion
This study demonstrates how standard and reproducible solutions can be applied in the implementation of medical registries to constitute a re-usable framework. Such approach has the potential to facilitate data integration between healthcare and research settings, also being a useful framework to be used in other biomedical registries. 相似文献194.
195.
Seveso Davide Arrigoni Roberto Montano Simone Maggioni Davide Orlandi Ivan Berumen Michael L. Galli Paolo Vai Marina 《Coral reefs (Online)》2020,39(1):85-98
Coral Reefs - Coral bleaching represents the most serious threat to contemporary coral reefs. In response, focus is being laid on understanding the cellular processes involved in the response of... 相似文献
196.
Calabrò Marco Mandelli Laura Crisafulli Concetta Porcelli Stefano Albani Diego Politis Antonis Papadimitriou George N. Di Nicola Marco Janiri Luigi Colombo Roberto Martinotti Giovanni Bellomo Antonello Vieta Eduard Bonassi Stefano Frustaci Alessandra Ducci Giuseppe Landi Stefano Boccia Stefania Serretti Alessandro 《Molecular biology reports》2020,47(1):191-200
Molecular Biology Reports - Serotoninergic system is one of the most important neurotransmission systems investigated in the field of psychiatry. Extensive evidence reveals how alterations of this... 相似文献
197.
Aureo Banhos Bruno L. Fontes Débora Regina Yogui Mario Henrique Alves Natália Carneiro Ardente Renata Valls Lucas Mendes Barreto Lucas Damásio Átilla Colombo Ferreguetti Andréa Siqueira Carvalho Vitor Roberto Schettino Alexandre Rosa dos Santos Helena Godoy Bergallo Ana Carolina Srbek-Araujo Emilia Patrícia Medici Ariel Canena Arnaud L.J. Desbiez 《Biotropica》2020,52(3):421-426
We report 24 records of giant armadillo roadkill on Brazilian highways in the Cerrado, Pantanal and Amazon biomes illustrating that highways are a threat to this species. However, we also documented the species using underpasses, demonstrating that these structures could help to reduce the risk of roadkill for giant armadillos. 相似文献
198.
Andrea Berruti Roberto Borriello Maria Teresa Della Beffa Valentina Scariot Valeria Bianciotto 《Symbiosis (Philadelphia, Pa.)》2013,61(2):63-76
Camellia japonica L. (Theaceae, Theales) is an acidophilic evergreen flowering shrub and is traded worldwide. Symbiotic associations between the roots of this plant species and arbuscular mycorrhizal fungi (AMF), commonly recognized as natural biofertilizers and biocontrol agents, have been poorly studied so far. The aim of our study was to verify whether the application of nonspecific commercial AMF-based inocula could succeed and improve the growth of C. japonica. An experiment was conducted concerning the application of commercial inocula constituted by a specific AMF isolate (Funneliformis mosseae) or a consortium of different fungi and bacteria as alternatives to fertilization in pot cultivated C. japonica ‘Dr. Burnside’. Several growth parameters, plant nutrition and mycorrhization levels were monitored at the end of plant cultivation. Generally, increases in some macroelements (Ca, Mg, K) and microelements (Cu, Mn, Fe, Zn) were detected in the root system of inoculated camellias, while only Cu and Mn accumulation was increased in the leaves. Plants inoculated with the consortium inoculum exhibited increased chlorophyll content and foliage diameter while plants inoculated with F. mosseae exhibited increased number of flowers. Based on the polymorphism of an 18S rDNA region, we assessed the inoculated AMF that colonized C. japonica roots. The experiments showed that the applied AMF poorly colonized the root system of C. japonica. We suggest that commercial AMF formulations should be more targeted and host-specific in order to successfully colonize the host root and, potentially, fully express their benefits. 相似文献
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200.