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71.
Chakravarthy VS Gupte N Yogesh S Salhotra A 《International journal of neural systems》2008,18(2):157-164
Synchronization of chaotic low-dimensional systems has been a topic of much recent research. Such systems have found applications for secure communications. In this work we show how synchronization can be achieved in a high-dimensional chaotic neural network. The network used in our studies is an extension of the Hopfield Network, known as the Complex Hopfield Network (CHN). The CHN, also an associative memory, has both fixed point and limit cycle or oscillatory behavior. In the oscillatory mode, the network wanders chaotically from one stored pattern to another. We show how a pair of identical high-dimensional CHNs can be synchronized by communicating only a subset of state vector components. The synchronizability of such a system is characterized through simulations. 相似文献
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73.
Rong Chen Alex A Morgan Joel Dudley Tarangini Deshpande Li Li Keiichi Kodama Annie P Chiang Atul J Butte 《Genome biology》2009,9(12):R170
Background
Candidate single nucleotide polymorphisms (SNPs) from genome-wide association studies (GWASs) were often selected for validation based on their functional annotation, which was inadequate and biased. We propose to use the more than 200,000 microarray studies in the Gene Expression Omnibus to systematically prioritize candidate SNPs from GWASs. 相似文献74.
The paper provides a comprehensive review of methodology for setting confidence intervals for the parameter of a Poisson distribution. The results are illustrated by a numerical example. 相似文献
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76.
Ultrasonic storage modulus as a novel parameter for analyzing protein-protein interactions in high protein concentration solutions: correlation with static and dynamic light scattering measurements 下载免费PDF全文
The purpose of this work was to establish ultrasonic storage modulus (G') as a novel parameter for characterizing protein-protein interactions (PPI) in high concentration protein solutions. Using an indigenously developed ultrasonic shear rheometer, G' for 20-120 mg/ml solutions of a monoclonal antibody (IgG(2)), between pH 3.0 and 9.0 at 4 mM ionic strength, was measured at frequency of 10 MHz. Our understanding of ultrasonic rheology indicated decrease in repulsive and increase in attractive PPI with increasing solution pH. To confirm this behavior, dynamic (DLS) and static (SLS) light scattering measurements were conducted in dilute solutions. Due to technical limitations, light scattering measurements could not be conducted in concentrated solutions. Mutual-diffusion coefficient, measured by DLS, increased with IgG(2) concentration at pH 4.0 and this trend reversed as pH was increased to 9.0. Second virial coefficient, measured by SLS, decreased with increasing pH. These observations were consistent with the nature of PPI understood from G' measurements. Ultrasonic rheology, DLS, and SLS measurements were also conducted under conditions of increased ionic strength. The consistency between rheology and light scattering analysis under various solution conditions established the utility of ultrasonic G' measurements as a novel tool for analyzing PPI in high protein concentration systems. 相似文献
77.
A novel pentasaccharide from immunostimulant oligosaccharide fraction of buffalo milk. 总被引:7,自引:0,他引:7
R Saksena D Deepak A Khare R Sahai L M Tripathi V M Srivastava 《Biochimica et biophysica acta》1999,1428(2-3):433-445
A processed oligosaccharide mixture of buffalo milk induced significant stimulation of antibody, delayed-type hypersensitivity response to sheep red blood cells in BALB/c mice. This also stimulated non-specific immune response of the animals measured in terms of macrophage migration index. A novel pentasaccharide has been isolated from the oligosaccharide containing fraction having immunostimulant activity of buffalo milk. This compound was isolated by a combination of gel filtration chromatography, silica gel column chromatography of derivatised oligosaccharides while the homogeneity was confirmed by high performance liquid chromatography. The results of structural analyses, i.e. proton nuclear magnetic resonance, fast atom bombardment mass spectrometry, chemical transformations and degradations are consistent with the following structure: GlcNAcbeta(1-->3)Galbeta(1-->4)GlcNAcbeta(1-->3)Gal beta(1-->4)Glc 相似文献
78.
Atul Kumar Brian Donley 《Computer methods in biomechanics and biomedical engineering》2014,17(16):1777-1784
This study was designed to examine the three-dimensional geometry of the head of the first metatarsal bone of the foot. Ninety-seven adult first metatarsal head (MTH1) bones were scanned using a laser scanner at 400 dpi. A best-fit ellipsoid was obtained from the articular surfaces of MTH1 for each size group using nonlinear unconstrained optimisation. Average root mean square errors between the articulating surfaces and the optimal fit surfaces of the bone specimens were between 0.29 and 0.42 mm. After classification based on sex and size groups, the profile provided a good fit to individual bones. Consideration of the thickness of cartilage overlying the metatarsal head (MTH) may further improve the fit. The proposed approach provides the basis for a design of an MTH hemi-arthroplasty that has good anatomical congruence with the native joint. 相似文献
79.