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61.
Kurt Nezahat Ozgeris Fatma B. Ucuz Ilknur Bayraktutan Zafer Kocak Yilmaz Kubra Demirdogen Esen Yildirim Cayir Atilla 《Biochemistry. Biokhimii?a》2022,87(6):559-565
Biochemistry (Moscow) - Early detection of cognitive developmental delay (CDD) and autism spectrum disorder (ASD) is challenging, despite the numerous scientific studies conducted and different... 相似文献
62.
Viktor Brovkovych Alyssa Aldrich Nasi Li G. Ekin Atilla‐Gokcumen Jonna Frasor 《Proteomics》2019,19(18)
The use of cultured cells has been instrumental in studying biochemical, molecular, and cellular processes. The composition of serum that cells are maintained in can have a profound impact on important cellular checkpoints. Cell growth and apoptosis are analyzed in an estrogen receptor positive breast cancer cell line in the presence of serum that have been treated to remove steroids or lipids, as well‐described in the literature. It is shown that maintaining cells in the presence of charcoal‐dextran‐treated serum causes reduced growth rate, which can be reversed by the addition of estradiol. Silica‐treated‐serum also slows down cell growth and induces apoptosis. In order to investigate the role of lipids in these phenotypes, the levels of a wide range of lipids in different sera are investigated. It is shown that silica‐treatment significantly depletes phosphatidylcholines and cholesterol. It is also shown that lipogenesis is stimulated when cells are cultured with silica‐treated‐serum and this is reversed by the addition of exogenous lipids, which also restores growth rate and apoptosis. The results show that cultured cells are sensitive to different serum, most likely due to the differences in levels of structural and signaling metabolites present in their growth environment. 相似文献
63.
Yazici M. Atilla Asif Muhammad Tutus Yusuf Ortas Ibrahim Ozturk Levent Lambers Hans Cakmak Ismail 《Plant and Soil》2021,459(1-2):19-21
Plant and Soil - Grass pea is a legume species with recognized resistance to several diseases and thus important for the improvement of related major legume crops. It is infected by the soil-borne... 相似文献
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65.
Thomas Deneke Karin Nentwich Rainer Schmitt Georgios Christhopoulos Joachim Krug Luigi Di Biase Andrea Natale Atilla Szollosi Andreas Mugge Patrick Muller Johannes W Dietrich Dong-In Shin Sebastian Kerber Anja Schade 《Indian pacing and electrophysiology journal》2014,14(5):240-249
Background
Silent cerebral events (SCE) have been identified on magnetic resonance imaging (MRI) in asymptomatic patients after atrial fibrillation (AF) ablation. Procedural determinants influencing the risk for SCE still remain unclear.Objective
Comparing the risk for SCE depending on exchanges of catheters (ExCath) over a single transseptal sheath.Methods
88 Patients undergoing pulmonary vein isolation (PVI) only ablation using either single-tip or balloon-based technique underwent pre- and post-ablation cerebral MRI. Ablations were either performed with double transseptal access and without exchanging catheters over the transseptal sheaths (group 1: no ExCath) or after a single transseptal access and exchanges of therapeutic and diagnostic catheters (group 2: ExCath). Differences in regard to SCE rates were analyzed. Multivariate analysis was performed to identify factors related to the risk for SCE.Results
Included patients underwent PVI using single tip irrigated radiofrequency in 41, endoscopic laser balloon in 27 and cryoballoon in 20 cases. Overall SCE were identified in 23 (26%) patients. In group 1 (no ExCath; N=46) 6 patients (13%) and in group 2 (N=42) 17 patients (40%) had documented SCE (p=0.007). The applied ablation technology did not affect SCE rate. In multivariate analysis age (OR 1.1, p=0.03) and catheter exchanges over a single transseptal sheath (OR 12.1, p=0.007) were the only independent predictors of a higher risk for SCE.Conclusions
Exchanging catheters over a single transseptal access to perform left atrial ablation is associated with a significantly higher incidence of SCE compared to an ablation technique using different transseptal accesses for therapeutic and diagnostic catheters. 相似文献66.
Özlen Güzel-Akdemir Atilla Akdemir Semra Isik Daniela Vullo Claudiu T. Supuran 《Bioorganic & medicinal chemistry》2013,21(6):1386-1391
By using phthalimido-substituted aromatic sufonamides as lead molecules, a series of new sulfonamides incorporating ortho-benzenedisulfonimide moieties have been synthesized and tested against the human (h) cytosolic carbonic anhydrase (CA, EC 4.2.1.1) isozymes hCA I and hCA II and the transmembrane, tumor-associated isozymes hCA IX and hCA XII. All these compounds showed Ki values lower than 100 nM and many of them showed better Kis than the reference compound acetazolamide, a clinically used sulfonamide. The tumor-associated isozymes were better inhibited than the cytosolic ones. A molecular docking within the active site of some CA isoforms, such as hCA I, explained these findings, as the benzenedisulfonimide moiety makes favorable interactions (hydrogen bonds) with amino acid residues involved in binding of inhibitors, such as Gln92, His67, and His64. 相似文献
67.
We propose a new geometric buildup algorithm for the solution of the distance geometry problem in protein modeling, which
can prevent the accumulation of the rounding errors in the buildup calculations successfully and also tolerate small errors
in given distances. In this algorithm, we use all instead of a subset of available distances for the determination of each
unknown atom and obtain the position of the atom by using a least-squares approximation instead of an exact solution to the
system of distance equations. We show that the least-squares approximation can be obtained by using a special singular value
decomposition method, which not only tolerates and minimizes small distance errors, but also prevents the rounding errors
from propagation effectively, especially when the distance data is sparse. We describe the least-squares formulations and
their solution methods, and present the test results from applying the new algorithm for the determination of a set of protein
structures with varying degrees of availability and accuracy of the distances. We show that the new development of the algorithm
increases the modeling ability, and improves stability and robustness of the geometric buildup approach significantly from
both theoretical and practical points of view. 相似文献
68.
Sinan Balci Mustafa Karabiyik Askin Kocabas Coskun Kocabas Atilla Aydinli 《Plasmonics (Norwell, Mass.)》2010,5(4):429-436
Surface plasmon polariton (SPP) waveguides formed by coupled plasmonic cavities on metallic Moire surfaces have been investigated
both experimentally and numerically. The Moire surface, fabricated by interference lithography, contains periodic arrays of
one-dimensional cavities. The coupling strength between the cavities has been controlled by changing the periodicities of
the Moire surface. The ability to control the coupling strength allows us to tune the dispersion and the group velocity of
the plasmonic coupled cavity mode. Reflection measurements and numerical simulation of the array of SPP cavities have shown
a coupled resonator type plasmonic waveguide band formation within the band gap. Coupling coefficients of cavities and group
velocities of SPPs are calculated for a range of cavity sizes from weakly coupled regime to strongly coupled regime. 相似文献
69.
Kiralp S Balik B Karatas S Toppare L Gungor A 《International journal of biological macromolecules》2008,42(2):191-194
In this study an alternative supporting electrolyte was used in enzyme immobilization. Invertase was studied to observe the effect of the supporting electrolyte. Sulfonated poly(arylene ether sulfone) was used as the supporting electrolyte during the electrolysis of pyrrole. The results show that the polymeric supporting electrolyte can be used instead of sodium dodecyl sulfate. 相似文献
70.
Personal model‐assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD 下载免费PDF全文
Adil Mardinoglu Elias Bjornson Cheng Zhang Martina Klevstig Sanni Söderlund Marcus Ståhlman Martin Adiels Antti Hakkarainen Nina Lundbom Murat Kilicarslan Björn M Hallström Jesper Lundbom Bruno Vergès Peter Hugh R Barrett Gerald F Watts Mireille J Serlie Jens Nielsen Mathias Uhlén Ulf Smith Hanns‐Ulrich Marschall Marja‐Riitta Taskinen Jan Boren 《Molecular systems biology》2017,13(3)
To elucidate the molecular mechanisms underlying non‐alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS). We obtained experimental data on lipoprotein fluxes and used these individual measurements as personalized constraints of a hepatocyte genome‐scale metabolic model to investigate metabolic differences in liver, taking into account its interactions with other tissues. Our systems level analysis predicted an altered demand for NAD+ and glutathione (GSH) in subjects with high HS. Our analysis and metabolomic measurements showed that plasma levels of glycine, serine, and associated metabolites are negatively correlated with HS, suggesting that these GSH metabolism precursors might be limiting. Quantification of the hepatic expression levels of the associated enzymes further pointed to altered de novo GSH synthesis. To assess the effect of GSH and NAD+ repletion on the development of NAFLD, we added precursors for GSH and NAD+ biosynthesis to the Western diet and demonstrated that supplementation prevents HS in mice. In a proof‐of‐concept human study, we found improved liver function and decreased HS after supplementation with serine (a precursor to glycine) and hereby propose a strategy for NAFLD treatment. 相似文献