全文获取类型
收费全文 | 355篇 |
免费 | 25篇 |
国内免费 | 2篇 |
出版年
2024年 | 1篇 |
2023年 | 6篇 |
2022年 | 10篇 |
2021年 | 27篇 |
2020年 | 8篇 |
2019年 | 11篇 |
2018年 | 22篇 |
2017年 | 11篇 |
2016年 | 25篇 |
2015年 | 22篇 |
2014年 | 26篇 |
2013年 | 25篇 |
2012年 | 22篇 |
2011年 | 29篇 |
2010年 | 7篇 |
2009年 | 10篇 |
2008年 | 12篇 |
2007年 | 15篇 |
2006年 | 13篇 |
2005年 | 15篇 |
2004年 | 8篇 |
2003年 | 6篇 |
2002年 | 7篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1996年 | 4篇 |
1994年 | 3篇 |
1992年 | 5篇 |
1991年 | 5篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1987年 | 2篇 |
1983年 | 1篇 |
1979年 | 1篇 |
1977年 | 4篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1962年 | 1篇 |
1950年 | 1篇 |
排序方式: 共有382条查询结果,搜索用时 62 毫秒
381.
Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase, E6-AP, Results in Tissue-Selective Steroid Hormone Resistance and Defects in Reproduction 下载免费PDF全文
Carolyn L. Smith Darryll G. DeVera Dolores J. Lamb Zafar Nawaz Yong-Hui Jiang Arthur L. Beaudet Bert W. OMalley 《Molecular and cellular biology》2002,22(2):525-535
The E6-associated protein (E6-AP), although originally identified as a ubiquitin ligase, has recently been shown to function as a coactivator of steroid receptor-dependent gene expression in in vitro assays. In order to determine whether E6-AP acts as a coactivator in vivo, physiological parameters associated with male and female sex steroid action were assessed in the E6-AP null mouse. Gonadal size was reduced in E6-AP null male and female mice in comparison to wild-type controls in conjunction with reduced fertility in both genders. Consistent with this observation, defects in sperm production and function, as well as ovulation were observed. In comparison to wild-type controls, induction of prostate gland growth induced by testosterone and uterine growth by estradiol were significantly reduced. In contrast, estrogen and progesterone-stimulated growth of virgin mammary gland was not compromised by E6-AP ablation despite E6-AP expression in this tissue. This latter finding contrasts with the impaired estrogen and progesterone-induced mammary gland development observed previously for steroid receptor coactivator type 1 (SRC-1) and SRC-3 female knockout mice. Taken together, these results are consistent with a role for E6-AP in mediating a subset of steroid hormone actions in vivo. Nevertheless, differences observed between SRC and E6-AP knockout phenotypes indicate that these two families of steroid receptor coactivators are not functionally equivalent and supports the hypothesis that coactivators contribute to tissue-specific steroid hormone action. 相似文献