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Anastasios Karatzas Vassilios Tzortzis Eirini Giannatou Stavros Gravas Ioannis Zachos Athanassios Oeconomou Michael Melekos Aspasia Tsezou 《Molecular biology reports》2013,40(12):6665-6669
Glucuronidation, mediated by the UDP-glucuronosyltransferase 1A1 (UGT1A1) enzyme, is an important metabolic process during which steroids are converted to more easily excreted compounds in steroid target tissues, such as the prostate. The aim of our study was to investigate the possible correlation between UGT1A1 promoter gene polymorphism and benign prostatic hyperplasia. 421 blood samples were obtained from 138 consecutive patients diagnosed with benign prostatic hypeplasia (BPH group) and 283 healthy volunteers (control group). A(TA)6TAA promoter polymorphism of UGT1A1 gene was studied using the Fragment Analysis Software of an automated DNA sequencer and three genotypes (homozygous 7/7, heterozygous 6/7 and normal homozygous 6/6) were identified. No significant differences were observed between the BPH group and controls regarding the genotyping distribution of the three UGT1A1 promoter genotypes (P = 0.39). Also, no association was found between overall disease risk and the presence of the polymorphic homozygous genotype (TA(7)/TA)7) vs. TA(6)/TA(7) + TA(6)/TA(6)) (P = 0.31). Our data suggest that the TA repeat polymorphism of UGT1A1 is not associated with increased BPH risk susceptibility in Caucasian men. 相似文献
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Ahmad A. Cluntun Rachit Badolia Sandra Lettlova K. Mark Parnell Thirupura S. Shankar Nikolaos A. Diakos Kristofor A. Olson Iosif Taleb Sean M. Tatum Jordan A. Berg Corey N. Cunningham Tyler Van Ry Alex J. Bott Aspasia Thodou Krokidi Sarah Fogarty Sophia Skedros Wojciech I. Swiatek Xuejing Yu Stavros G. Drakos 《Cell metabolism》2021,33(3):629-648.e10
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