Facile synthesis,spectroscopic evaluation and antimicrobial screening of metal endowed triazole compounds

The scientific interest in developing new complexes as inhibitors of bacterial biofilm related infections is constantly rising. The present work describes the chemical synthesis, structural and biological scrutiny of a triazole Schiff base ligand and its corresponding complexes. Triazole Schiff base, (2-methoxy-4-[(1H-1,2,4-triazol-3-ylimino)methyl]phenol) was synthesized from the condensation reaction of 3-amino-1,2,4-triazole and 4-hydroxy-3-methoxybenzaldehyde in an equimolar ratio. The triazole ligand (H₂L) was characterized by physical (solubility, color, melting point), spectroscopic [UV–visible (UV–Vis), Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (¹H-NMR) and mass spectra (MS)] and micro analysis to evaluate their elemental composition. The bidentate ligand was complexed with transition metal [VO(IV), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)] in 1:2 molar ratio. The complexes were characterized by physical (color, solubility, decomposition temperature, conductance and magnetic moment), FT-IR, UV–Vis and elemental analysis. Thermal stability and fluorescence properties of the compounds were also determined. Density functional theory based theoretical calculations were accomplished to gain more insight into spectroscopic properties. The frontier molecular orbital analysis revealed that the ligand was less reactive with reduced electron donating capability and more kinetic stability than complexes. The as-synthesized compounds were scrutinized for anti-bacterial and anti-fungal activity against selected strains. Cobalt complex exhibited highest antibacterial activity against Escherichia coli and nickel complex has shown highest antifungal activity against Aspergillus niger. All the compounds also showed good antioxidant activity. The theoretical results reflect consistency with the experimental findings signifying that such compounds could be the promising chemical scaffolds in the near future against microbial infectious.

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Chitosan hydrogel microspheres: an effective covalent matrix for crosslinking of soluble dextranase to increase stability and recycling efficiency

Bioprocess and Biosystems Engineering - Dextranase is a unique biocatalyst that has high specificity and stereo-selectivity towards a complex biopolymer known as dextran. Dextranase has wide...     

Biologically Active Pyridazines and Pyridazinone Derivatives: A Scaffold for the Highly Functionalized Compounds

Russian Journal of Bioorganic Chemistry - Pyridazine and pyridazinone are heterocycles that contain two adjacent nitrogen atoms and shown wide range of pharmacological activities such as...     

Duration of luteal support (DOLS) with progesterone pessaries to improve the success rates in assisted conception: study protocol for a randomized controlled trial

ABSTRACT: BACKGROUND: Luteal phase support has been shown by a meta analysis of prospective randomised studies, to be beneficial in establishing a pregnancy after IVF. The optimal length of treatment is unresolved at present and it remains unclear how long to treat women receiving luteal supplementation. It has been used for as little as 2 weeks and for as long as 12 weeks of gestation. OBJECTIVE: To conduct a prospective randomised double blind study to investigate the effect of the duration of luteal support with progesterone in IVF cycles. Trial design: Following 2 weeks of standard treatment and a positive biochemical pregnancy test, this randomised control trial will allocate women to a supplementary 8 weeks of treatment of vaginal progesterone or 8 weeks of placebo. Eligibility: All women presenting to the Hewitt Centre for Reproductive Medicine, Liverpool Women's NHS Foundation Trust, for assisted conception with a positive biochemical pregnancy test at 2 weeks post embryo transfer are eligible to enter the trial. Primary outcome measure:The primary outcome measure is the proportion of all randomised women that continue successfully to a viable pregnancy (at least one fetus with FHR >100 beats minute) on transabdominal / transvaginal ultrasound at 10 weeks post embryo transfer / 12 weeks gestation (i.e. at the end of 8 weeks supplementary trial treatment).     

Managing overloaded hosts for energy-efficiency in cloud data centers

Cluster Computing - Traditional data centers are shifted toward the cloud computing paradigm. These data centers support the increasing demand for computational and data storage that consumes a...     

Cultivable bacteria in the supraglacial lake formed after a glacial lake outburst flood in northern Pakistan

International Microbiology - Recently, a supraglacial lake formed as a result of a glacial lake outburst flood (GLOF) in the Dook Pal Glacier. Lake debris and meltwater samples were collected from...     

Prospects of Inducing Resistance in Fodder Species against Toxic Ions and Metals

ABSTRACT

Experiments were carried out with various salts and their combinations to ascertain the impact of these salts on seedling traits of fodder species and to identify tolerant species. Length-based traits showed a repressed effect, whereas weight-based traits were increased under salt stress. Furthermore, accumulation of Na⁺, Ca²⁺, and Cl^? ions and metals (Cu²⁺, Fe²⁺, and Al³⁺) increased in various organs of seedlings due to various salt treatments. Contrastingly, K⁺, K⁺/Na⁺, and Ca²⁺/Cl^? decreased, showing priority for specific salts. Seedling traits, such as shoot length sensitivity and shoot biomass, provide an effective mean of selection for tolerant or susceptible genotypes. Diverse types of tolerance mechanisms were present in cultivars to detoxify the effect of ions and metals. Cultivars that showed low susceptibility index, high shoot biomass, and high metal concentration were salt includers and could be utilized for bioremediation of the affected areas, whereas tolerant cultivars that showed low susceptibility index, metals concentration, and comparable shoot biomass to that of the control were salt excluders and could be utilized for fodder purposes.