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91.
Ashham Mansur Maximilian Steinau Aron Frederik Popov Sinisa Milenovic Christian Bireta Alexander Weymann Hanna Schotola Christoph H. Wiese Tim Beissbarth Mladen Tzvetkov José Hinz 《PloS one》2015,10(6)
Genetic variants within the endothelin-1 gene (EDN1) have been associated with several cardiovascular diseases and may act as genetic prognostic markers. Here, we explored the overall relevance of EDN1 polymorphisms for long-term survival in patients undergoing on-pump cardiac surgery. A prospectively collected cohort of 455 Caucasian patients who underwent cardiac surgery with cardiopulmonary bypass was followed up for 5 years. The obtained genotypes and inferred haplotypes were analyzed for their associations with the five-year mortality rate (primary endpoint). The EDN1 T-1370G and K198N genotype distributions did not deviate from Hardy–Weinberg equilibrium and the major allele frequencies were 83% and 77%, respectively. The cardiovascular risk factors were equally distributed in terms of the different genotypes and haplotypes associated with the two polymorphisms. The five-year mortality rate did not differ among the different EDN1 T-1370G and K198N genotypes and haplotypes. Haplotype analysis revealed that carriers of the G-T (compound EDN1 T-1370G G/K198N T) haplotype had a higher cardiac index than did non-carriers (p = 0.0008); however, this difference did not reach significance after adjusting for multiple testing. The results indicate that common variations in EDN1 do not act as prognostic markers for long-term survival in patients undergoing on-pump cardiac surgery. 相似文献
92.
Mycelium of Arbuscular Mycorrhizal fungi (AMF) from different genera: form, function and detection 总被引:13,自引:2,他引:11
John C. Dodd Claire L. Boddington Alia Rodriguez Carmen Gonzalez-Chavez Irdika Mansur 《Plant and Soil》2000,226(2):131-151
It is often assumed that all species of arbuscular mycorrhizal fungi (AMF) have the same function because of the ubiquity
of the arbuscular mycorrhizal symbiosis and the fact that all AMF occupy the same plant/soil niche. Despite apparent differences
in the timing of evolutionary divergence and the morphological characteristics of AMF from the different genera, the majority
of studies on these fungi use only species of Glomus. There is increasing evidence, however, that the mechanisms involved in the establishment of a mycorrhiza may differ for
species and genera of AMF and influence their subsequent function. The aim of this paper is to highlight the diversity in
the form and function of AMF from different genera, knowledge of which is vital in understanding their ecological roles. Potential
use of biochemical and molecular approaches to detect AMF in planta and ex planta is also discussed.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
93.
J. S. Lakind S. T. Holgate D. R. Ownby A. H. Mansur P. J. Helms D. Pyatt 《Biomarkers》2013,18(5):445-467
Biomarkers associated with asthma aetiology and exacerbation have been sought to shed light on this multifactorial disease. One candidate is the serum concentration of the Clara cell secretory protein (CC16, sometimes referred to as CC10 or uteroglobin). In this review, we examine serum CC16's relation to asthma aetiology and exacerbation. There is evidence that acute exposures to certain pulmonary irritants can cause a transient increase in serum CC16 levels, and limited evidence also suggests that a transient increase in serum CC16 levels can be caused by a localized pulmonary inflammation. Research also indicates that a transient increase in serum CC16 is not associated with measurable pulmonary damage or impairment of pulmonary function. The biological interpretation of chronic changes in serum CC16 is less clear. Changes in serum CC16 concentrations (either transient or chronic) are not specific to any one agent, disease state, or aetiology. This lack of specificity limits the use of serum CC16 as a biomarker of specific exposures. To date, many of the critical issues that must be understood before serum CC16 levels can have an application as a biomarker of effect or exposure have not been adequately addressed. 相似文献
94.
95.
Longo Pedro Augusto dos Santos Mansur Karine Ferreira Ribeiro Siqueira Silvana Gomes Leite Passos Flávio Dias Leite Fosca Pedini Pereira 《Aquatic Ecology》2021,55(2):623-646
Aquatic Ecology - Anthropogenic impacts cause habitat losses and reduce biodiversity in marine coastal habitats. Coastal macroalgae beds and their associate invertebrates are highly susceptible to... 相似文献
96.
97.
Benfield CT Mansur DS McCoy LE Ferguson BJ Bahar MW Oldring AP Grimes JM Stuart DI Graham SC Smith GL 《The Journal of biological chemistry》2011,286(23):20727-20735
98.
Saeid Javadi Khederi Enrico de Lillo Mohammad Khanjani Mansur Gholami 《Experimental & applied acarology》2014,63(1):15-35
The interaction of grape erineum mite (GEM), Colomerus vitis Pagenstecher (Acari: Eriophyidae), with grape was investigated in the laboratory. We studied some plant morphological biochemical features potentially related to vine resistance/tolerance of eight native grapevine cultivars, extensively cultivated in western Iran, and two non-native cultivars. Free-choice experiments indicated that the cultivars Shahani, Flame seedless and Yaghuti were colonized by lower levels of GEM, whereas Muscat Gordo, Gazne and White Thompson seedless hosted denser populations. These differences between cultivars may be due to differential attractiveness to GEM, possibly associated with plant biochemical and morphological traits. In no-choice assays with six grapevine cultivars, mite population development and some cultivar features were assessed. Mite populations grew fastest on Gazne and Muscat Gordo, and slowest on Yaghuti and Shahani. The degree of mite infestation was associated with reduction of leaf area, increase of leaf weight, shortening of shoots and more numerous erinea: these features were larger on the most infested Gazne, whereas morphological features of Shahani and Yaghuti were scarcely affected by GEM infestation. Also trichome type and density of the assayed cultivars appeared to be related to mite density: the most infested cultivars (Gazne and Muscat Gordo) displayed higher ranks of blade and vein hairs and lower ranks of blade and vein bristles and domatia. No correlation was found between mite density and leaf thickness of mature leaves. The amount of leaf waxes was highest in Shahani and Yaghuti, which displayed the lowest mite density, the fewest erinea and the largest leaves. Carbohydrate amount of uninfested leaves was lowest on the least infested Shahani and highest on the most infested Gazne; phenols increased in leaves of Shahani and decreased in those of Gazne after mite infestation. Finally, cultivars also appeared to influence some morphological traits of the mites: larger specimens were detected on White Thompson seedless, Flame seedless and Gazne, whereas smaller mites were found on leaves of the less infested Yaghuti and Shahani. These results indicate that leaf hairiness, leaf wax and carbohydrate contents may be useful tools for a preliminary screening among vine cultivars and help predict resistance/tolerance to GEM. Shahani and Yaghuti seem quite promising for developing grape resistance programs against GEM in western Iran. 相似文献
99.
Mohamad Ali Roozegar Tayebeh Malek Mohammadi Mohamad Reza Havasian Jafar Panahi Amirreza Hashemian Mansur Amraei Behzad Hoshmand 《Bioinformation》2015,11(2):96-100
Periodontium is a complex organ composed of mineralized epithelial and connective tissue. Dexamethasone could stimulate
proliferation of osteoblast and fibroblasts. This study aimed to assess the osteogenic effect of dexamethasone on periodental
ligament (PDL) stem cells. PDL stem cells were collected from periodontal ligament tissue of root of extracted premolar of young
and healthy people. The stem cells were cultured in α-MEM Medium in three groups, one group with basic medium contains (α-
MEM and FBS 10 % and 50 mmol of β_ gelisrophosphat and L_ ascorbic acid µg/ml), the second group: basic medium with
dexamethasone and the third one: basic medium without any osteogenic stimulant. Mineralization of cellular layer was analyzed
with Alizarin red stain method. Osteogenic analysis was done by Alkaline phosphates and calcium test. These analysis indicated
that the amount of intra-cellular calcium and alkaline phosphates in the Dexamethasone group was far more than the control and
basic group (P<0.05). The results of Alizarin red stain indicated more mineralization of cultured cells in Dexamethasone group
(P<0.05). The study results showed that Dexamethasone has significant osteogenic effect on PDL stem cells and further studies are
recommended to evaluate its effect on treatment of bone disorders. 相似文献
100.
Maznah Dahlui Nazar Azahar Awang Bulgiba Rafdzah Zaki Oche Mansur Oche Felix Oluyemi Adekunjo Karuthan Chinna 《PloS one》2015,10(12)