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Akira Shibanuma Evelyn Korkor Ansah Kimiyo Kikuchi Francis Yeji Sumiyo Okawa Charlotte Tawiah Keiko Nanishi Sheila Addei John Williams Kwaku Poku Asante Abraham Oduro Seth Owusu-Agyei Margaret Gyapong Gloria Quansah Asare Junko Yasuoka Abraham Hodgson Masamine Jimba the Ghana EMBRACE Implementation Research Project Team 《PLoS medicine》2021,18(6)
BackgroundIn low- and middle-income countries (LMICs), the continuum of care (CoC) for maternal, newborn, and child health (MNCH) is not always complete. This study aimed to evaluate the effectiveness of an integrated package of CoC interventions on the CoC completion, morbidity, and mortality outcomes of woman–child pairs in Ghana.Methods and findingsThis cluster-randomized controlled trial (ISRCTN: 90618993) was conducted at 3 Health and Demographic Surveillance System (HDSS) sites in Ghana. The primary outcome was CoC completion by a woman–child pair, defined as receiving antenatal care (ANC) 4 times or more, delivery assistance from a skilled birth attendant (SBA), and postnatal care (PNC) 3 times or more. Other outcomes were the morbidity and mortality of women and children. Women received a package of interventions and routine services at health facilities (October 2014 to December 2015). The package comprised providing a CoC card for women, CoC orientation for health workers, and offering women with 24-hour stay at a health facility or a home visit within 48 hours after delivery. In the control arm, women received routine services only. Eligibility criteria were as follows: women who gave birth or had a stillbirth from September 1, 2012 to September 30, 2014 (before the trial period), from October 1, 2014 to December 31, 2015 (during the trial period), or from January 1, 2016 to December 31, 2016 (after the trial period). Health service and morbidity outcomes were assessed before and during the trial periods through face-to-face interviews. Mortality was assessed using demographic surveillance data for the 3 periods above. Mixed-effects logistic regression models were used to evaluate the effectiveness as difference in differences (DiD). For health service and morbidity outcomes, 2,970 woman–child pairs were assessed: 1,480 from the baseline survey and 1,490 from the follow-up survey. Additionally, 33,819 cases were assessed for perinatal mortality, 33,322 for neonatal mortality, and 39,205 for maternal mortality. The intervention arm had higher proportions of completed CoC (410/870 [47.1%]) than the control arm (246/620 [39.7%]; adjusted odds ratio [AOR] for DiD = 1.77; 95% confidence interval [CI]: 1.08 to 2.92; p = 0.024). Maternal complications that required hospitalization during pregnancy were lower in the intervention (95/870 [10.9%]) than in the control arm (83/620 [13.4%]) (AOR for DiD = 0.49; 95% CI: 0.29 to 0.83; p = 0.008). Maternal mortality was 8/6,163 live births (intervention arm) and 4/4,068 live births during the trial period (AOR for DiD = 1.60; 95% CI: 0.40 to 6.34; p = 0.507) and 1/4,626 (intervention arm) and 9/3,937 (control arm) after the trial period (AOR for DiD = 0.11; 95% CI: 0.11 to 1.00; p = 0.050). Perinatal and neonatal mortality was not significantly reduced. As this study was conducted in a real-world setting, possible limitations included differences in the type and scale of health facilities and the size of subdistricts, contamination for intervention effectiveness due to the geographic proximity of the arms, and insufficient number of cases for the mortality assessment.ConclusionsThis study found that an integrated package of CoC interventions increased CoC completion and decreased maternal complications requiring hospitalization during pregnancy and maternal mortality after the trial period. It did not find evidence of reduced perinatal and neonatal mortality.Trial registrationThe study protocol was registered in the International Standard Randomised Controlled Trial Number Registry (90618993).Akira Shibanuma and co-workers study a package of maternal and child health interventions in a cluster-randomized trial done in Ghana. 相似文献
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Kobina Assan Ampah Beatrice Nickel Prince Asare Amanda Ross Daniel De-Graft Sarah Kerber Ralf Spallek Mahavir Singh Gerd Pluschke Dorothy Yeboah-Manu Katharina R?ltgen 《PLoS neglected tropical diseases》2016,10(1)
The debilitating skin disease Buruli ulcer (BU) is caused by infection with Mycobacterium ulcerans. While various hypotheses on potential reservoirs and vectors of M. ulcerans exist, the mode of transmission has remained unclear. Epidemiological studies have indicated that children below the age of four are less exposed to the pathogen and at lower risk of developing BU than older children. In the present study we compared the age at which children begin to develop antibody responses against M. ulcerans with the age pattern of responses to other pathogens transmitted by various mechanisms. A total of 1,352 sera from individuals living in the BU endemic Offin river valley of Ghana were included in the study. While first serological responses to the mosquito transmitted malaria parasite Plasmodium falciparum and to soil transmitted Strongyloides helminths emerged around the age of one and two years, sero-conversion for M. ulcerans and for the water transmitted trematode Schistosoma mansoni occurred at around four and five years, respectively. Our data suggest that exposure to M. ulcerans intensifies strongly at the age when children start to have more intense contact with the environment, outside the small movement range of young children. Further results from our serological investigations in the Offin river valley also indicate ongoing transmission of Treponema pallidum, the causative agent of yaws. 相似文献
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Tissue nitrogen was assessed monthly for 16 months in five species of perennial macroalgae representing three phyla at one location in Rhode Island Sound. The species showed a remarkable similarity in their pattern of seasonal fluctuation in both nitrate and total nitrogen. The period of greatest accumulation (January through March) coincided with the period of highest concentration of inorganic nitrogen in the water, and for most of these algae it was also the time of-least growth. Conversely, the period of lowest tissue nitrogen (50% of the winter value, May through July) coincided with the period of lowest inorganic nitrogen in the water and highest algal growth. The greatest accumulation of nitrate was found in Laminaria saccharina (L.) Lamour. (80 μmol·g dry wt.?1), four times as much as that measured simultaneously in the other species and 560 times the ambient concentration. By April the concentration of internal nitrate had dropped to nearly undetectable levels, but in August it began to accumulate again—a pattern that was repeated in Chondrus crispus Stackh. In Ascophyllum nodosum (L.) Le Jolis, Fucus vesiculosus L. and Codium fragile subsp. tomentosoides (Van Goor) Silva, the period of negligible internal nitrate level extended from March to December. The greatest concentration of total tissue nitrogen was measured in C. crispus (4.8% dry wt.), double the maximum in L. saccharina (2.3% dry wt.). 相似文献