全文获取类型
收费全文 | 342篇 |
免费 | 33篇 |
出版年
2024年 | 1篇 |
2023年 | 2篇 |
2022年 | 11篇 |
2021年 | 20篇 |
2020年 | 11篇 |
2019年 | 21篇 |
2018年 | 17篇 |
2017年 | 5篇 |
2016年 | 18篇 |
2015年 | 28篇 |
2014年 | 20篇 |
2013年 | 28篇 |
2012年 | 21篇 |
2011年 | 19篇 |
2010年 | 9篇 |
2009年 | 12篇 |
2008年 | 23篇 |
2007年 | 21篇 |
2006年 | 32篇 |
2005年 | 12篇 |
2004年 | 11篇 |
2003年 | 9篇 |
2002年 | 7篇 |
2001年 | 4篇 |
2000年 | 4篇 |
1998年 | 1篇 |
1997年 | 3篇 |
1994年 | 3篇 |
1992年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有375条查询结果,搜索用时 265 毫秒
61.
P. A. Slominsky O. V. Pivovarova M. I. Shadrina A. V. Artem’eva F. G. Pfaipffer N. N. Rudovich S. E. Agadghanyan V. S. Pronin S. A. Limborska 《Russian Journal of Genetics》2009,45(1):113-117
Association of 13 single nucleotide polymorphisms (SNPs) of insulinase (IDE) gene with type 2 diabetes mellitus (T2D) in the Moscow population has been examined. Three polymorphic markers (rs7078413, rs7899603, and rs551266) associated with the risk of T2D development have been revealed. Allele and genotype frequency distribution for these three markers differed significantly only in the sample of females between T2D patients and control individuals, while only in case of rs7078413 SNP genotype frequencies varied significantly in the total population. 相似文献
62.
63.
64.
A new species of the viviparous fish genus Grammonus (Ophidiiformes: Bythitidae) is described, based on two ripe males, 32–55 mm SL. They were caught over a muddy bottom in a
shrimp trawl at 70–119 m off Central Vietnam. A comparison with the nine hitherto described Grammonus species shows them to be clearly distinct from other species. Except for G. ater, G. minutus differs from all other species by having either more or fewer dorsal (75–76) and anal (54–55) fin rays. It differs from G. ater i.a. by having more pectoral fin rays (22–23 vs. 18–19). 相似文献
65.
Warshakoon NC Wu S Boyer A Kawamoto R Sheville J Renock S Xu K Pokross M Zhou S Winter C Walter R Mekel M Evdokimov AG 《Bioorganic & medicinal chemistry letters》2006,16(21):5517-5522
A new series of potent 8-hydroxyquinolines was designed based on the newly resolved X-ray crystal structure of EGLN-1. Both alkyl and aryl 8-hydroxyquinoline-7-carboxyamides were good HIF-1alpha prolyl hydroxylase (EGLN) inhibitors. In subsequent VEGF induction assays, these exhibited potent VEGF activity. In addition, this class of compounds did show the ability to stabilize HIF-1alpha. 相似文献
66.
Sabat M VanRens JC Laufersweiler MJ Brugel TA Maier J Golebiowski A De B Easwaran V Hsieh LC Walter RL Mekel MJ Evdokimov A Janusz MJ 《Bioorganic & medicinal chemistry letters》2006,16(23):5973-5977
This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent analogs disclosed showed low nanomolar activity for the inhibition of Lck kinase and a representative analog was co-crystallized with Hck (a structurally related member of the Src family kinases). 相似文献
67.
Cell adhesion plays a central role in multicellular organisms helping to maintain their integrity and homeostasis. This complex process involves many different types of adhesion proteins, and synergetic behavior of these proteins during cell adhesion is frequently observed in experiments. A well-known example is the cooperation of rolling and stationary adhesion proteins during the leukocytes extravasation. Despite the fact that such cooperation is vital for proper functioning of the immune system, its origin is not fully understood. In this study we constructed a simple analytic model of the interaction between a leukocyte and the blood vessel wall in shear flow. The model predicts existence of cell adhesion bistability, which results from a tug-of-war between two kinetic processes taking place in the cell-wall contact area—bond formation and rupture. Based on the model results, we suggest an interpretation of several cytoadhesion experiments and propose a simple explanation of the existing synergy between rolling and stationary adhesion proteins, which is vital for effective cell adherence to the blood vessel walls in living organisms. 相似文献
68.
Bavencoffe A Kondratskyi A Gkika D Mauroy B Shuba Y Prevarskaya N Skryma R 《The Journal of biological chemistry》2011,286(11):9849-9855
Cold/menthol-activated TRPM8 (transient receptor potential channel melastatin member 8) is primarily expressed in sensory neurons, where it constitutes the principal receptor of environmental innocuous cold. TRPM8 has been shown to be regulated by multiple influences such as phosphorylation, pH, Ca(2+), and lipid messengers. One such messenger is arachidonic acid (AA), which has been shown to inhibit TRPM8 channel activity. However, the physiological pathways mediating the inhibitory effect of AA on TRPM8 still remain unknown. Here, we demonstrate that TRPM8 is regulated via M3 muscarinic acetylcholine receptor-coupled signaling cascade based on the activation of cytosolic phospholipase A2 (cPLA2) and cPLA2-catalyzed derivation of AA. Stimulation of M3 receptors heterologously co-expressed with TRPM8 in HEK-293 cells by nonselective muscarinic agonist, oxotremorine methiodide (Oxo-M), caused inhibition of TRPM8-mediated membrane current, which could be mimicked by AA and antagonized by pharmacological or siRNA-mediated cPLA2 silencing. Our results demonstrate the intracellular functional link between M3 receptor and TRPM8 channel via cPLA2/AA and suggest a novel physiological mechanism of arachidonate-mediated regulation of TRPM8 channel activity through muscarinic receptors. We also summarize the existing TRPM8 regulations and discuss their physiological and pathological significance. 相似文献
69.
The Use of Phosphite‐Type Ligands in the Ir‐Catalyzed Asymmetric Hydrogenation of Heterocyclic Compounds
下载免费PDF全文
![点击此处可从《Chirality》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Sergey E. Lyubimov Dmitry V. Ozolin Pavel Yu Ivanov Artem Melman Valeriya S. Velezheva Vadim A. Davankov 《Chirality》2014,26(1):56-60
A series of chiral phosphite‐type ligands was tested in asymmetric Ir‐catalyzed hydrogenation of quinolines and 2,4,5,6‐tetrahydro‐1H‐pyrazino(3,2,1‐j,k)carbazole. Hydrogenation of quinaldine hydrochloride provided superior enantioselectivity up to 65% ee compared to quinaldine free base. The ligands were tested for the first time in the asymmetric Ir‐Ircatalyzed hydrogenation of 2,4,5,6‐tetrahydro‐1H‐pyrazino(3,2,1‐j,k)carbazole yielding the antidepressant drug, pirlindole. Chirality 26:56–60, 2013. © 2013 Wiley Periodicals, Inc. 相似文献