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331.
Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner. 总被引:8,自引:0,他引:8 下载免费PDF全文
Armelle A. Troussard Clara Tan T. Nathan Yoganathan Shoukat Dedhar 《Molecular and cellular biology》1999,19(11):7420-7427
332.
Armelle Baeza-Squiban Emmanuelle Boisvieux-Ulrich Catherine Guilianelli Odile Houcine Gérard Geraud Christiane Guennou Francelyne Marano 《In vitro cellular & developmental biology. Animal》1994,30(1):56-67
Summary The differentiation of tracheal epithelial cells in primary culture was investigated according to the nature of the extracellular
matrix used. Cultures obtained by the explant technique were realized on a type I collagen substratum either as a thin, dried
coating or as a thick, hydrated gel supplemented with culture medium and serum. These two types of substratum induced distinct
cell morphology and cytokeratin expression in the explant derived cells. Where cells are less proliferating (from Day 7 to
10 of culture), differentiation was evaluated by morphologic ultrastructural observations, immunocytochemical detection of
cytokeratins, and determination of cytokeratin pattern by biochemical analysis.
The epithelium obtained on gel was multilayered, with small, round basal cells under large, flattened upper cells. The determination
of the keratin pattern expressed by cells grown on gel revealed an expression of keratin 13, already considered as a specific
marker of squamous metaplasia, that diminished with retinoic acid treatment. Present results demonstrated by confocal microscopy
that K13-positive cells were large upper cells with a dense keratin network, whereas lower cells were positively stained with
a specific monoclonal antibody to basal cells (KB37). Moreover, keratin neosynthesis analysis pointed out a higher expression
of K6, a marker of hyperproliferation, on gel than on coating. All these data suggest a differentiation of rabbit tracheal
epithelial cells grown on gel toward squamous metaplasia. By contrast, the epithelium observed on coating is nearly a monolayer
of very large and spread out cells. No K13-positive cells were observed, but an increase in the synthesis of simple epithelium
marker (K18) was detected. These two substrata, similar in composition and different in structure, induce separate differentiation
and appear as good tools to explore the mechanisms of differentiation of epithelial tracheal cells. 相似文献
333.
Aline Rigal Rime Michael-Jubeli Alex Nkengne Arlette Baillet-Guffroy Armelle Bigouret Ali Tfayli 《Journal of biophotonics》2021,14(9):e202100107
Skin aging is a multifactorial phenomenon that involves alterations at the molecular, cellular and tissue levels. Our aim was to carry out a multiparametric biophysical and Raman characterization of skin barrier between individuals of different age groups (<24 and >70 years old). Our results showed a significant decrease of lipids to proteins ratio overall the thickness of the stratum corneum and higher lateral packing in the outer part of the SC for elderly. This can explain the decrease in trans epidermal water loss measured values rather than only SC thickening. Both age groups showed similar water content at SC surface while elderly presented higher water content in deep SC and viable epidermis. Mechanical measurements showed a decrease in the elasticity and an increase in the fatigability with age and were correlated with partially bound water. Highest correlation and anti-correlation values were observed for the deepest part of the SC and the viable epidermis. 相似文献
334.
Bessou Cécile Tailleur Aurélie Godard Caroline Gac Armelle de la Cour Julie Lebas Boissy Joachim Mischler Pierre Caldeira-Pires Armando Benoist Anthony 《The International Journal of Life Cycle Assessment》2020,25(7):1217-1230
The International Journal of Life Cycle Assessment - Soil organic carbon (SOC) plays a key role in soil functioning and in greenhouse gas exchange with the atmosphere. Land use and land use changes... 相似文献