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11.
Zvezdochkina NV Muranova LN Andrianov VV Arkhipova SS Gaĭnutdinov KhL Golubev AI Pleshchinskiĭ IN 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2004,90(11):1381-1392
Two groups of rats with different level of motor activities: high- and low-active animals, were distinguished. The blockade of dopamine receptors by haloperidol led to depression of locomotor activity in both groups of rats; in grape snails, haloperidol caused a decrease of the velocity of locomotor responses. In was found that within 5 minutes of intravenous injection of haloperidol the excitability of spinal centers of rats decreased; but in 30 minutes in started restoring. Chronic application of the preparation depressed the effect of posttetanic potentiation of H-response in gastrocnemius muscle of spinal rats. In command neurons of grape snail, chronic injections of haloperidol causes a significant hyperpolarization shift of membrane potential and an increase of threshold of the generation of action potential. It was shown that the selective pharmacological inhibition of dopaminergic system of the brain led to a decrease of excitability in some determined neurons of the snail and spinal motor centers of rats, as well as inhibited the locomotor responses both in vertebrate and in invertebrate animals. 相似文献
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Based on the 31P NMR, PMR, and EPR data on the thermally induced behavior of water dispersions of natural and synthetic phospholipids in the presence of membranotropic agents: the neuropeptide adrenocorticotropic hormone and beta-(4-oxy,3,5-ditretbutyl-phenylpropionic acid), a new mechanism of the interaction of membranotropic substances with the molecules of hydrate shells of membrane phospholipids was proposed, which underlies polymorphic transitions in phosphatidylcholine membranes. 相似文献
14.
On the basis of experimental data on the thermoinduced state of water dispersions of natural and synthetic phospholipids in the presence of nootropic agents, a new phenomenological molecular mechanism of information recording/reading was proposed. The mechanism is based on the polymorphism of membrane lipids. A new approach, to the problem of memory was suggested, which considers memory as an information data bank and separates this concept from the concept of the mechanisms of information recording/reading. 相似文献
15.
Elena O. Omarova Pavel A. Nazarov Alexander M. Firsov Marina G. Strakhovskaya Anastasia Yu. Arkhipova Mikhail M. Moisenovich Igor I. Agapov Valentina A. Ol’shevskaya Andrey V. Zaitsev Valery N. Kalinin Elena A. Kotova Yuri N. Antonenko 《PloS one》2015,10(11)
Antimicrobial photodynamic inactivation is currently being widely considered as alternative to antibiotic chemotherapy of infective diseases, attracting much attention to design of novel effective photosensitizers. Carboranyl-chlorin-e6 (the conjugate of chlorin e6 with carborane), applied here for the first time for antimicrobial photodynamic inactivation, appeared to be much stronger than chlorin e6 against Gram-positive bacteria, such as Bacillus subtilis, Staphyllococcus aureus and Mycobacterium sp. Confocal fluorescence spectroscopy and membrane leakage experiments indicated that bacteria cell death upon photodynamic treatment with carboranyl-chlorin-e6 is caused by loss of cell membrane integrity. The enhanced photobactericidal activity was attributed to the increased accumulation of the conjugate by bacterial cells, as evaluated both by centrifugation and fluorescence correlation spectroscopy. Gram-negative bacteria were rather resistant to antimicrobial photodynamic inactivation mediated by carboranyl-chlorin-e6. Unlike chlorin e6, the conjugate showed higher (compared to the wild-type strain) dark toxicity with Escherichia coli ΔtolC mutant, deficient in TolC-requiring multidrug efflux transporters. 相似文献
16.
Batchaev KhKh Arapova VI Pilipenko TD Bolatchiev KKh Arkhipova NI 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2007,(2):87-89
Incidence and etiologic structure of shigellosis in Karachaevo-Cherkes Republic for 10 years are analyzed and compared with same characteristics in Russia overall. Sharp rise of shigellosis cases number is detected in 2003-2005 as well as predominance of Shigella sonnei represented by biovar Ilg. It was shown that Shigella strains with different resistance to tetracycline and chloramphenicol circulate in Karachaevo-Cherkes Republic. 相似文献
17.
Kuzmina L. Yu. Gilvanova E. A. Galimzyanova N. F. Arkhipova T. N. Ryabova A. S. Aktuganov G. E. Sidorova L. V. Kudoyarova G. R. Melent’ev A. I. 《Microbiology》2022,91(2):173-183
Microbiology - The strain of facultative chemolithotrophic bacteria isolated from soil within the aphotic zone of the Kinderlinskaya Cave (Southern Urals, Russia) was identified as member of the... 相似文献
18.
T. N. Arkhipova S. U. Veselov A. I. Melentiev E. V. Martynenko G. R. Kudoyarova 《Plant and Soil》2005,272(1-2):201-209
Hormone production by micro-organisms selected as antagonists of pathogenic fungi and the effect of their introduction into soil on hormone content and growth of lettuce plants were studied. Hormones in bacterial cultural media and in plant extracts were immunopurified and assayed using specific antibodies to indolyl-3-acetic acid (IAA), abscisic acid (ABA), and different cytokinins (zeatin riboside (ZR), dihydrozeatinriboside (DHZR) and isopentenyladenosine (iPA)). ZR was shown to be the main cytokinin present in bacterial cultural media as a complex with a high molecular weight component. Inoculation of lettuce plants with bacteria increased the cytokinin content of both shoots and roots. Accumulation of zeatin and its riboside was greatest in roots shortly 2days after inoculation, when their content was 10 times higher than in control. Changes in the content of other hormones (ABA and IAA) were observed at the end of experiments only. Accumulation of cytokinins in inoculated lettuce plants was associated with an increase in plant shoot and root weight of approximately 30% over 8days. 相似文献
19.
Arkhipova OV Grishin SN Sitdikova GF Zefirov AL 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2005,91(3):268-276
Arachidonic acid and prostaglandin E2 decreased the frequency of miniature endplate currents without changing their amplitude-temporary parameters. They also reduced the evoked transmitter release and the amplitude of the 3rd phase of nerve ending response corresponding to the voltage-dependent K(+)-current. Using perineural recording, It was shown that arachidonic acid and prostaglandin E2 decreased the Ca2+ currents of nerve endings. Indometacin: inhibitor of cyclooxygenase, enhanced the evoked transmitter release and decreased the 3rd phase of nerve ending response. Indometacin prevented the effects of arachidonic acid on evoked transmitter release, whereas the effects of arachidonic acid on the 3rd phase was preserved. Prostaglandin E2 seems to mediate the effects of arachidonic acid on spontaneous and evoked transmitter release, Ca(2+)- and Ca(2+)-activated K(+)-currents. Moreover, the arachidonic acid and prostaglandin E2 exerted their own effects upon voltage-dependent potassium current of motor nerve ending. 相似文献
20.
A. V. Kulikov L. V. Arkhipova E. G. Novoselova N. V. Shishova D. A. Kulikov G. N. Smirnova 《Biophysics》2008,53(6):659-662
It has been demonstrated that an atopic transplantation of the thymus tissue from young animals in different variants decreased the rate of irreversible age-related atrophy of the thymus in a statistically significant manner. This retards an age-dependent degradation of the T-cell component of the immune system. 相似文献