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151.
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Bloomfield Laura S. P. Tracey Christopher Mbabazi Edith Schultz Rhiannon L. Henderson Rebecca Bardosh Kevin Randolph Shannon Paige Sarah 《EcoHealth》2022,19(2):299-314
EcoHealth - The majority of emerging and re-emerging infectious diseases in people are zoonotic. Despite substantial research in communities adjacent to protected areas with high levels of... 相似文献
153.
Photosynthesis Research - The trimeric nature of the Fenna–Matthews–Olson (FMO) protein antenna complex from green sulfur phototrophic bacteria was investigated. Mutations were... 相似文献
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H. Schultz 《International Review of Hydrobiology》1990,75(1):109-109
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Kaley M. Wilburn Christine R. Montague Bo Qin Ashley K. Woods Melissa S. Love Case W. McNamara Peter G. Schultz Teresa L. Southard Lu Huang H. Michael Petrassi Brian C. VanderVen 《PLoS pathogens》2022,18(2)
There is a growing appreciation for the idea that bacterial utilization of host-derived lipids, including cholesterol, supports Mycobacterium tuberculosis (Mtb) pathogenesis. This has generated interest in identifying novel antibiotics that can disrupt cholesterol utilization by Mtb in vivo. Here we identify a novel small molecule agonist (V-59) of the Mtb adenylyl cyclase Rv1625c, which stimulates 3’, 5’-cyclic adenosine monophosphate (cAMP) synthesis and inhibits cholesterol utilization by Mtb. Similarly, using a complementary genetic approach that induces bacterial cAMP synthesis independent of Rv1625c, we demonstrate that inducing cAMP synthesis is sufficient to inhibit cholesterol utilization in Mtb. Although the physiological roles of individual adenylyl cyclase enzymes in Mtb are largely unknown, here we demonstrate that the transmembrane region of Rv1625c is required during cholesterol metabolism. Finally, the pharmacokinetic properties of Rv1625c agonists have been optimized, producing an orally-available Rv1625c agonist that impairs Mtb pathogenesis in infected mice. Collectively, this work demonstrates a role for Rv1625c and cAMP signaling in controlling cholesterol metabolism in Mtb and establishes that cAMP signaling can be pharmacologically manipulated for the development of new antibiotic strategies. 相似文献
159.
M J LaDu C J Schultz D A Essig W K Palmer 《The International journal of biochemistry》1991,23(4):405-411
1. A triglyceride (TG) lipase is present in whole homogenate and tissue extracts of beef myocardium with characteristics of lipoprotein lipase (LPL); i.e., activity is stimulated by serum, inhibited by NaCl and protamine sulfate, the protein binds to heparin-Sepharose, and the enzyme has an alkaline pH optimum. 2. This TG lipase, eluted from heparin-Sepharose at 0.9-1.0 M NaCl, has an apparent mol. wt of 64 K daltons. Its primary mRNA is 3.7 kb. 3. Expression of LPL mRNA and enzyme activities are in the ratio of approximately 20:8:1 for hearts of mouse, rat and beef, respectively and correlate with r = +0.99. 相似文献
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