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171.
Lisondro Isaac Gómez Serrano Cintia Sepúlveda Claudia Batista Ceballos Ariadna Indira Acién Fernández Francisco Gabriel 《Journal of applied phycology》2022,34(1):19-30
Journal of Applied Phycology - In this paper the influence of irradiance and the operation modes on biomass production and biochemical composition, especially the fatty acid profile, on the diatom... 相似文献
172.
Aneta Aniela Kowalska Ariadna B. Nowicka Tomasz Szymborski Patrycja Piecyk Agnieszka Kamińska 《Journal of biophotonics》2021,14(1):e202000318
Selectin ligands are present on the surface of tumor cells, for this reason lowering the L-selectin level in the blood and lymph can indicate presence of the tumor. Therefore the selectin level in the plasma are potential targets for anticancer therapy. We demonstrate the surface enhanced Raman spectroscopy (SERS)-based sensor for the determination of L-selectin level in biological samples that can be used in medical diagnosis. The combination of SERS with the method of multivariate analysis as principle component analysis (PCA) allows to strengthen the presented data analysis. The loadings of PCA permit to indicate those vibration modes, that are the most important for the assumed identification (bands at 1574, 1450, 1292 cm−1). Two bands at 1286 and 1580 cm−1 were selected for the determination of the calibration curve (bands intensities I1286/I1580 ratio). The L-selectin level of biological samples can be read, directly from the calibration curve. The presented sensor is as a sensitive tool with good specificity and selectivity of L-selectin, even in the case of coexistence of P- and E-selectin. 相似文献
173.
Ariadna P. Velázquez Takashi Tatsuta Ruben Ghillebert Ingmar Drescher Martin Graef 《The Journal of cell biology》2016,212(6):621-631
Lipid droplets (LDs) are conserved organelles for intracellular neutral lipid storage. Recent studies suggest that LDs function as direct lipid sources for autophagy, a central catabolic process in homeostasis and stress response. Here, we demonstrate that LDs are dispensable as a membrane source for autophagy, but fulfill critical functions for endoplasmic reticulum (ER) homeostasis linked to autophagy regulation. In the absence of LDs, yeast cells display alterations in their phospholipid composition and fail to buffer de novo fatty acid (FA) synthesis causing chronic stress and morphologic changes in the ER. These defects compromise regulation of autophagy, including formation of multiple aberrant Atg8 puncta and drastically impaired autophagosome biogenesis, leading to severe defects in nutrient stress survival. Importantly, metabolically corrected phospholipid composition and improved FA resistance of LD-deficient cells cure autophagy and cell survival. Together, our findings provide novel insight into the complex interrelation between LD-mediated lipid homeostasis and the regulation of autophagy potentially relevant for neurodegenerative and metabolic diseases. 相似文献
174.