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251.
Daiane Borges Machado Elizabeth Williamson Julia M. Pescarini Flavia J. O. Alves Luís F. S. Castro-de-Araujo Maria Yury Ichihara Laura C. Rodrigues Ricardo Araya Vikram Patel Maurício L. Barreto 《PLoS medicine》2022,19(5)
BackgroundSocioeconomic factors have been consistently associated with suicide, and economic recessions are linked to rising suicide rates. However, evidence on the impact of socioeconomic interventions to reduce suicide rates is limited. This study investigates the association of the world’s largest conditional cash transfer programme with suicide rates in a cohort of half of the Brazilian population.Methods and findingsWe used data from the 100 Million Brazilian Cohort, covering a 12-year period (2004 to 2015). It comprises socioeconomic and demographic information on 114,008,317 individuals, linked to the “Bolsa Família” programme (BFP) payroll database, and nationwide death registration data. BFP was implemented by the Brazilian government in 2004. We estimated the association of BFP using inverse probability of treatment weighting, estimating the weights for BFP beneficiaries (weight = 1) and nonbeneficiaries by the inverse probability of receiving treatment (weight = E(ps)/(1-E(ps))). We used an average treatment effect on the treated (ATT) estimator and fitted Poisson models to estimate the incidence rate ratios (IRRs) for suicide associated with BFP experience. At the cohort baseline, BFP beneficiaries were younger (median age 27.4 versus 35.4), had higher unemployment rates (56% versus 32%), a lower level of education, resided in rural areas, and experienced worse household conditions. There were 36,742 suicide cases among the 76,532,158 individuals aged 10 years, or older, followed for 489,500,000 person-years at risk. Suicide rates among beneficiaries and nonbeneficiaries were 5.4 (95% CI = 5.32, 5.47, p < 0.001) and 10.7 (95% CI = 10.51, 10.87, p < 0.001) per 100,000 individuals, respectively. BFP beneficiaries had a lower suicide rate than nonbeneficiaries (IRR = 0.44, 95% CI = 0.42, 0.45, p < 0.001). This association was stronger among women (IRR = 0.36, 95% CI = 0.33, 0.38, p < 0.001), and individuals aged between 25 and 59 (IRR = 0.41, 95% CI = 0.40, 0.43, p < 0.001). Study limitations include a lack of control for previous mental disorders and access to means of suicide, and the possible under-registration of suicide cases due to stigma.ConclusionsWe observed that BFP was associated with lower suicide rates, with similar results in all sensitivity analyses. These findings should help to inform policymakers and health authorities to better design suicide prevention strategies. Targeting social determinants using cash transfer programmes could be important in limiting suicide, which is predicted to rise with the economic recession, consequent to the Coronavirus Disease 2019 (COVID-19) pandemic.In a quasi-experimental study, Daiane Borges Machado and colleagues investigate the association between rates of suicide and the Bolsa Familia cash transfer program in the 100 Million Brazilian Cohort. 相似文献
252.
Daniel González-Acuña Jorge Hernández Lucila Moreno Bjorn Herrmann Ricardo Palma Alejandra Latorre Gonzalo Medina-Vogel Mike J. Kinsella Nicolas Martín Karolina Araya Iván Torres Nicolás Fernandez Bjorn Olsen 《Polar Biology》2013,36(12):1749-1760
Historically wildlife conservation was based on habitat protection and exploitation control. Only recently have diseases been considered an important issue. However, pathogens are usually described during or after disease outbreaks, but to determine which pathogens may be emerging, surveys of wildlife health are critical in a given time. This study deals with the health status of gentoo penguins Pygoscelis papua in two localities at the Antarctica Peninsula and one at Ardley Island off the South Shetland Islands. Cloacal swaps, fresh fecal samples, ectoparasites, and blood smears were collected. We examined and dissected 14 penguin corpses found dead. Fecal samples were positive for Campylobacter, Escherichia coli and in the carcasses four endoparasitic species were found: Diphyllobothrium sp. and Parorchites zederi, Corynosoma shackletoni and Stegophorus adeliae. The tick Ixodes uriae occurred in five of the examined penguins, and the louse Austrogoniodes gressitti on six birds. From the colony grounds, we collected 1,184 I. uriae. We recorded antibiotic-resistant bacteria, such as E. coli, in ecosystems where gentoo penguins breed. Cloacal samples (300) were negative for Chlamydia, as well as for Salmonella, Campylobacter, E. coli, Newcastle and Influenza viruses. 相似文献
253.
Cristian Arévalo Juanita Freer Pamela A. Naulin Nelson P. Barrera Eduardo Troncoso Juan Araya Carlos Peña-Farfal Rosario del P. Castillo 《Bioenergy Research》2017,10(3):714-727
Dilute acid hydrolysis (DAH) and auto-hydrolysis (AU) have demonstrated to be optimal pre-treatments for the generation of biofuels from wood. Recent studies have highlighted the importance of ensuring the accessibility of cellulose enzymes during the enzymatic hydrolysis (EH) of pre-treated materials. In this work, the microscopic and nanoscopic structures of Eucalyptus globulus samples pre-treated by AU and DAH were evaluated by different techniques to understand the effect of the ultrastructure of samples on the enzymatic conversion and cellulose accessibility for bioethanol production. Microscopic techniques revealed changes in the physical characteristics of pre-treated fibers, coalescence at microscopic level, and differences in the chemical distribution of lignocellulosic components depending on the severity and type of pre-treatment. The atomic force microscopy-based nanoscopic study of samples showed differences in the effect of the pre-treatments on the ultrastructure of samples, with DAH pre-treatment producing major changes in the secondary cell wall with respect to AU samples at comparable severities, and a positive effect of the DAH ultrastructure changes to increase the EH yield. 相似文献
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256.
Muñoz C Pérez M Orrego PR Osorio L Gutiérrez B Sagua H Castillo JL Martínez-Oyanedel J Arroyo R Meza-Cervantez P da Silveira JF Midlej V Benchimol M Cordero E Morales P Araya JE González J 《International journal for parasitology》2012,42(8):715-727
In this work, evidence for a critical role of Trichomonas vaginalis protein phosphatase 1 gamma (TvPP1γ) in proliferation and attachment of the parasite to the mammalian cell is provided. Firstly, proliferation and attachment of T. vaginalis parasites to HeLa cells was blocked by calyculin A (CA), a potent PP1 inhibitor. Secondly, it was demonstrated that the enzyme activity of native and recombinant TvPP1γ proteins was inhibited by CA. Thirdly, reverse genetic studies confirmed that antisense oligonucleotides targeted to PP1γ but not PP1α or β inhibited proliferation and attachment of trichomonads CA-treated parasites underwent cytoskeletal modifications, including a lack of axostyle typical labelling, suggesting that cytoskeletal phosphorylation could be regulated by a CA-sensitive phosphatase where the role of PP1γ could not be ruled out. Analysis of subcellular distribution of TvPP1γ by cell fractionation and electron microscopy demonstrated the association between TvPP1γ and the cytoskeleton. The expression of adhesins, AP120 and AP65, at the cell surface was also inhibited by CA. The concomitant inhibition of expression of adhesins and changes in the cytoskeleton in CA-treated parasites suggest a specific role for PP1γ -dependent dephosphorylation in the early stages of the host-parasite interaction. Molecular modelling of TvPP1γ showed the conservation of residues critical for maintaining proper folding into the gross structure common to PP1 proteins. Taken together, these results suggest that TvPP1γ could be considered a potential novel drug target for treatment of trichomoniasis. 相似文献
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259.
Juan Francisco Araya 《ZooKeys》2013,(257):89-101
A new species of the genus Aeneator Finlay, 1926 is described from off the coast of Caldera (27°S), northern Chile. Aeneator martae sp. n. has a small, broad, stout, angulated shell with more prominent axial ribs and a more obviously keeled periphery than all previously named Chilean species. Comparisons are provided with all other South American named species of Aeneator. 相似文献
260.
Figueroa P Léon G Elorza A Holuigue L Araya A Jordana X 《Plant molecular biology》2002,50(4-5):725-734
Mitochondrial respiratory complex II contains four subunits: a flavoprotein (SDH1), an iron-sulphur subunit (SDH2) and two membrane anchor subunits (SDH3 and SDH4). We have found that in Arabidopsis thaliana SDH1 and SDH3 are encoded by two, and SDH4 by one nuclear genes, respectively. All these encoded polypeptides are found to be imported into isolated plant mitochondria. While both SDH1 proteins are highly conserved when compared to their counterparts in other organisms, SDH3 and SDH4 share little similarity with non-plant homologues. Expression of SDH1-1, SDH3 and SDH4 genes was detected in all tissues analysed, with the highest steady-state mRNA levels found in flowers and inflorescences. In contrast, the second SDH1 gene (SDH1-2) is expressed at a low level. 相似文献