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排序方式: 共有108条查询结果,搜索用时 15 毫秒
101.
ŞEKER Perinçek Seçkinozan SELÇUK Ahmet Yesari SELVİ Engin BARAN Mehmet TEBER Saffet KELEŞ Gökçe Ali KEFELİOĞLU Haluk TEZ Coşkun İBİŞ Osman 《Organisms Diversity & Evolution》2022,22(3):821-841
Organisms Diversity & Evolution - The complete mitochondrial DNA (mitogenome) sequences of Chionomys nivalis and C. roberti were first presented as reference mitogenomes by the current study... 相似文献
102.
Christian Appelt Axel Wessolowski Margitta Dathe Peter Schmieder 《Journal of peptide science》2008,14(4):524-527
New antimicrobial compounds are of major importance because of the growing problem of bacterial resistance. In this context, antimicrobial peptides have received a lot of attention. Their mechanism of action, however, is often obscure. Here, the structures of two cyclic, antimicrobial peptides from the family of arginine- and tryptophan-rich peptides determined in a membrane-mimicking environment are described. The sequence of the peptides has been obtained from a cyclic parent peptide by scrambling the amino acids. While the activity of the peptides is similar to that of the parent peptide, the structures are not. The peptides do, however, all adopt an amphiphilic structure. A comparison between the structures helps to define the requirements for the activity of these peptides. 相似文献
103.
104.
Proteins of the Bacillus stearothermophilus ribosome. A 5 A structure analysis of protein S5 总被引:1,自引:0,他引:1
The structure of protein S5 from the small subunit of the Bacillus stearothermophilus ribosome is described to a resolution of 5 A. The molecular boundary is visible and shows the protein to be essentially compact although slightly elongated in one dimension. 相似文献
105.
A protein structural motif that bends DNA 总被引:25,自引:0,他引:25
106.
K Appelt J Dijk R Reinhardt S Sanhuesa S W White K S Wilson A Yonath 《The Journal of biological chemistry》1981,256(22):11787-11790
Several individual intact ribosomal proteins purified from bacterial sources under mild conditions have been crystallized. A number of these are suitable candidates for three-dimensional structural studies by x-ray diffraction techniques. Data collection to 3 A resolution for one of these proteins is in progress. 相似文献
107.
As a contribution to the occurrence of ergot alkaloids in ergot from German rye and triticale, samples from the 2007 and 2008
harvests were analyzed. Twelve alkaloids—six pairs of main alkaloids and their corresponding epimers—were determined in extracts
prepared under alkaline conditions by HPLC with fluorescence detection without preceding purification. The total alkaloid
content was found to be 0.03–0.18% in ergot from rye (n = 19) and 0.06–0.22% in ergot from triticale (n = 4), respectively. Furthermore, single sclerotia (n = 40) were investigated in terms of alkaloid content and distributional pattern. The main alkaloids in ergot were ergocristine,
ergotamine and ergocornine, although the alkaloid composition was highly variable.
Presented in part at the 30th Mykotoxin-Workshop, Utrecht, The Netherlands, April 28–30, 2008 相似文献
108.
Graham H. Jackson Charlotte Pawlyn David A. Cairns Ruth M. de Tute Anna Hockaday Corinne Collett John R. Jones Bhuvan Kishore Mamta Garg Cathy D. Williams Kamaraj Karunanithi Jindriska Lindsay Alberto Rocci John A. Snowden Matthew W. Jenner Gordon Cook Nigel H. Russell Mark T. Drayson Walter M. Gregory Martin F. Kaiser Roger G. Owen Faith E. Davies Gareth J. Morgan the UK NCRI Haemato-oncology Clinical Studies Group 《PLoS medicine》2021,18(1)
BackgroundCarfilzomib is a second-generation irreversible proteasome inhibitor that is efficacious in the treatment of myeloma and carries less risk of peripheral neuropathy than first-generation proteasome inhibitors, making it more amenable to combination therapy.Methods and findingsThe Myeloma XI+ trial recruited patients from 88 sites across the UK between 5 December 2013 and 20 April 2016. Patients with newly diagnosed multiple myeloma eligible for transplantation were randomly assigned to receive the combination carfilzomib, lenalidomide, dexamethasone, and cyclophosphamide (KRdc) or a triplet of lenalidomide, dexamethasone, and cyclophosphamide (Rdc) or thalidomide, dexamethasone, and cyclophosphamide (Tdc). All patients were planned to receive an autologous stem cell transplantation (ASCT) prior to a randomisation between lenalidomide maintenance and observation. Eligible patients were aged over 18 years and had symptomatic myeloma. The co-primary endpoints for the study were progression-free survival (PFS) and overall survival (OS) for KRdc versus the Tdc/Rdc control group by intention to treat. PFS, response, and safety outcomes are reported following a planned interim analysis. The trial is registered (ISRCTN49407852) and has completed recruitment. In total, 1,056 patients (median age 61 years, range 33 to 75, 39.1% female) underwent induction randomisation to KRdc (n = 526) or control (Tdc/Rdc, n = 530). After a median follow-up of 34.5 months, KRdc was associated with a significantly longer PFS than the triplet control group (hazard ratio 0.63, 95% CI 0.51–0.76). The median PFS for patients receiving KRdc is not yet estimable, versus 36.2 months for the triplet control group (p < 0.001). Improved PFS was consistent across subgroups of patients including those with genetically high-risk disease. At the end of induction, the percentage of patients achieving at least a very good partial response was 82.3% in the KRdc group versus 58.9% in the control group (odds ratio 4.35, 95% CI 3.19–5.94, p < 0.001). Minimal residual disease negativity (cutoff 4 × 10−5 bone marrow leucocytes) was achieved in 55% of patients tested in the KRdc group at the end of induction, increasing to 75% of those tested after ASCT. The most common adverse events were haematological, with a low incidence of cardiac events. The trial continues to follow up patients to the co-primary endpoint of OS and for planned long-term follow-up analysis. Limitations of the study include a lack of blinding to treatment regimen and that the triplet control regimen did not include a proteasome inhibitor for all patients, which would be considered a current standard of care in many parts of the world.ConclusionsThe KRdc combination was well tolerated and was associated with both an increased percentage of patients achieving at least a very good partial response and a significant PFS benefit compared to immunomodulatory-agent-based triplet therapy.Trial registrationClinicalTrials.gov ISRCTN49407852.Graham Jackson and co-workers study a combination induction treatment including carfilzomib for patients with transplant-eligible myeloma. 相似文献