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排序方式: 共有321条查询结果,搜索用时 203 毫秒
151.
Melinda S. Martin Karoni Dutt Ligia A. Papale C��line M. Dub�� Stacey B. Dutton Georgius de Haan Anupama Shankar Sergio Tufik Miriam H. Meisler Tallie Z. Baram Alan L. Goldin Andrew Escayg 《The Journal of biological chemistry》2010,285(13):9823-9834
Voltage-gated sodium channels are required for the initiation and propagation of action potentials. Mutations in the neuronal voltage-gated sodium channel SCN1A are associated with a growing number of disorders including generalized epilepsy with febrile seizures plus (GEFS+),7 severe myoclonic epilepsy of infancy, and familial hemiplegic migraine. To gain insight into the effect of SCN1A mutations on neuronal excitability, we introduced the human GEFS+ mutation SCN1A-R1648H into the orthologous mouse gene. Scn1aRH/RH mice homozygous for the R1648H mutation exhibit spontaneous generalized seizures and premature death between P16 and P26, whereas Scn1aRH/+ heterozygous mice exhibit infrequent spontaneous generalized seizures, reduced threshold and accelerated propagation of febrile seizures, and decreased threshold to flurothyl-induced seizures. Inhibitory cortical interneurons from P5-P15 Scn1aRH/+ and Scn1aRH/RH mice demonstrated slower recovery from inactivation, greater use-dependent inactivation, and reduced action potential firing compared with wild-type cells. Excitatory cortical pyramidal neurons were mostly unaffected. These results suggest that this SCN1A mutation predominantly impairs sodium channel activity in interneurons, leading to decreased inhibition. Decreased inhibition may be a common mechanism underlying clinically distinct SCN1A-derived disorders. 相似文献
152.
Vasiyani Hitesh Shinde Anjali Roy Milton Mane Minal Singh Kritarth Singh Jyoti Gohel Dhruv Currim Fatema Vaidya Khushali Chhabria Mahesh Singh Rajesh 《Apoptosis : an international journal on programmed cell death》2021,26(5-6):293-306
Apoptosis - Immune adaptor protein like STING/MITA regulate innate immune response and plays a critical role in inflammation in the tumor microenvironment and regulation of metastasis including... 相似文献
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Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism 总被引:1,自引:0,他引:1
A. Jeremy Willsey Stephan J. Sanders Mingfeng Li Shan Dong Andrew T. Tebbenkamp Rebecca A. Muhle Steven K. Reilly Leon Lin Sofia Fertuzinhos Jeremy A. Miller Michael T. Murtha Candace Bichsel Wei Niu Justin Cotney A. Gulhan Ercan-Sencicek Jake Gockley Abha R. Gupta Wenqi Han Xin He Ellen J. Hoffman Lambertus Klei Jing Lei Wenzhong Liu Li Liu Cong Lu Xuming Xu Ying Zhu Shrikant M. Mane Ed S. Lein Liping Wei James P. Noonan Kathryn Roeder Bernie Devlin Nenad Sestan Matthew W. State 《Cell》2013
155.
Al-Hourani BJ Sharma SK Mane JY Tuszynski J Baracos V Kniess T Suresh M Pietzsch J Wuest F 《Bioorganic & medicinal chemistry letters》2011,21(6):1823-1826
A series of 1,5-diaryl-substituted tetrazole derivatives was synthesized via conversion of readily available diaryl amides into corresponding imidoylchlorides followed by reaction with sodium azide. All compounds were evaluated by cyclooxygenase (COX) assays in vitro to determine COX-1 and COX-2 inhibitory potency and selectivity. Tetrazoles 3a-e showed IC50 values ranging from 0.42 to 8.1 mM for COX-1 and 2.0 to 200 μM for COX-2. Most potent compound 3c (IC50 (COX-2) = 2.0 μM) was further used in molecular modeling docking studies. 相似文献
156.
Pushalkar S Mane SP Ji X Li Y Evans C Crasta OR Morse D Meagher R Singh A Saxena D 《FEMS immunology and medical microbiology》2011,61(3):269-277
In the oral cavity, chronic inflammation has been observed at various stages of oral squamous cell carcinomas (OSCC). Such inflammation could result from persistent mucosal or epithelial cell colonization by microorganisms. There is increasing evidence of the involvement of oral bacteria in inflammation, warranting further studies on the association of bacteria with the progression of OSCC. The objective of this study was to evaluate the diversity and relative abundance of bacteria in the saliva of subjects with OSCC. Using 454 parallel DNA sequencing, ~58,000 PCR amplicons that span the V4-V5 hypervariable region of rRNAs from five subjects were sequenced. Members of eight phyla (divisions) of bacteria were detected. The majority of classified sequences belonged to the phyla Firmicutes (45%) and Bacteroidetes (25%). Further, 52 different genera containing approximately 860 (16.51%) known species were identified and 1077 (67%) sequences belonging to various uncultured bacteria or unclassified groups. The species diversity estimates obtained with abundance-based coverage estimators and Chao1 were greater than published analyses of other microbial profiles from the oral cavity. Fifteen unique phylotypes were present in all three OSCC subjects. 相似文献
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Switzer WM Zheng H Simmons G Zhou Y Tang S Shankar A Kapusinszky B Delwart EL Heneine W 《PloS one》2011,6(12):e29223