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91.
The transcription factors SOX9 and SOX10 are vitiligo autoantigens in autoimmune polyendocrine syndrome type I. 总被引:4,自引:0,他引:4
92.
Leena Peltonen Piritta Koistinen Milja Karjalainen Antti Häkkinen Jouni Hirvonen 《AAPS PharmSciTech》2002,3(4):52-58
The aim of this study was to formulate nanoparticles from poly(I)lactide by a modified nanoprecipitation method. The main
focus was to study the effect of cosolvent selection on the shape, size, formation efficiency, degree of crystallinity, x-ray
diffraction (XRD) reflection pattern, and zeta potential value of the particles. Low-molecular-weight (2000 g/mol) poly(I)lactide
was used as a polymer, and sodium cromoglycate was used as a drug. Acetone, ethanol, and methanol were selected as cosolvents.
Optimal nanoparticles were achieved with ethanol as a cosolvent, and the formation efficiency of the particles was also higher
with ethanol as compared with acetone or methanol. The particles formulated by ethanol and acetone appeared round and smooth,
while with methanol they were slightly angular. When the volume of the inner phase was decreased during the nanoprecipitation
process, the mean particle size was also decreased with all the solvents, but the particles were more prone to aggregate.
The XRD reflection pattern and the degree of crystallinity were more dependent were more prone to aggregate. The XRD reflection
pattern and the degree of crystallinity were more dependent on the amount of the solvents in the inner phase than on the properties
of the individual cosolvents. The zeta potential values of all the particle batches were slightly negative, which partially
explains the increased tendency toward particle aggregation. 相似文献
93.
Reviews in Fish Biology and Fisheries - 相似文献
94.
Serum concentrations of dehydroepiandrosterone (DHEA), androstenedione, testosterone, 5 alpha-dihydrotestosterone and cortisol were measured in 10 infants (age 5-22 months) before, during and after 6-weeks of ACTH therapy for infantile spasms. During therapy, their mean DHEA concentrations increased 2.3-fold, androstenedione 12.3-fold, testosterone 2.7-fold, 5 alpha-dihydrotesterone 2.5-fold and cortisol 2.9-fold compared to pre-therapy values. Serum dehydroepiandrosterone sulphate (DHEA-S) concentrations were also increased during ACTH therapy above the normal prepubertal range. Three days after the cessation of ACTH treatment, all androgens had returned to the pre-therapy level. We conclude: At least in pharmacologic doses ACTH alone stimulates adrenal androgen secretion in infants, excluding the necessity of a separate adrenal androgen stimulating hormone. 相似文献
95.
Ornithine Decarboxylase Activity in Brain Regulated by a Specific Macromolecul, the Antizyme 总被引:1,自引:0,他引:1
Paivi H. Laitinen Riitta-Liisa Huhtinen Oili A. Hietala Antti E. I. Pajunen 《Journal of neurochemistry》1985,44(6):1885-1891
Mouse brain ornithine decarboxylase activity is about 70-fold higher at the time of birth compared with that of adult mice. Enzyme activity declines rapidly after birth and reaches the adult level by 3 weeks. Immunoreactive enzyme concentration parallels very closely the decrease of enzyme activity during the first postnatal week, remaining constant thereafter. The content of brain antizyme, the macromolecular inhibitor to ornithine decarboxylase, in turn is very low during the first 7 days and starts then to increase and at the age of 3 weeks it is about six times the level of that in newborn mice. This may explain the decrease in enzyme activity during brain maturation, and suggests the regulation of polyamine biosynthesis by an antizyme-mediated mechanism in adult brain. 相似文献
96.
Leaching losses of nitrogen from a clay soil under grass and cereal crops in Finland 总被引:1,自引:0,他引:1
Antti Jaakkola 《Plant and Soil》1984,76(1-3):59-66
Summary A 16-plot experimental field was established in 1975 on a clay soil in Jokioinen, Finland. The water discharge through tile drains was measured and its ammonium and nitrate N contents determined for each plot separately. The surface runoff was also measured and analysed. The annual runoff and the N leached from the surface of moderately fertilized (100 kg/ha/y N) cereal plots varied during 1976–1982 from 21 to 301 mm and from 2 to 7 kg/ha, respectively. The discharge of water and leaching of N through subdrains varied from 65 to 225 mm and from 1 to 38 kg/ha, respectively. The highest leaching was probably caused by a previous fallow. The annual N uptake by the crop varied between 41 and 122 kg/ha.Of the fertilizer-N used for cereals, 20% of that applied in the autumn was lost, but only 1 to 4 per cent was lost when applied in the spring. There was much less N leaching from ley than from barley plots, although the former was given twice as much N. The rate of N fertilization had only a very slight effect on N leaching from both ley and barley plots.The results were compared with those obtained in lysimeters filled with clay, silt, sand and peat soils. No definite conclusions can be drawn because the lysimeter experimental data are only for the first year. 相似文献
97.
98.
Adil Mardinoglu Hao Wu Elias Bjornson Cheng Zhang Antti Hakkarainen Sari M. Räsänen Sunjae Lee Rosellina M. Mancina Mattias Bergentall Kirsi H. Pietiläinen Sanni Söderlund Niina Matikainen Marcus Ståhlman Per-Olof Bergh Martin Adiels Brian D. Piening Marit Granér Nina Lundbom Jan Borén 《Cell metabolism》2018,27(3):559-571.e5
99.
100.
Patrick Jern Antti Kärnä Janna Hujanen Tatu Erlin Annika Gunst Helmi Rautaheimo Emilia Öhman S. Craig Roberts Brendan P. Zietsch 《Evolution and human behavior》2018,39(4):373-379
A number of recent studies have implicated that incongruent use of hormonal contraceptives (HCs) negatively affects various aspects of women's romantic relationships. It has been suggested that women with incongruent HC use (a discrepancy in HC use status between when they first met their current partner and the time of study participation) report less sexual satisfaction and higher jealousy scores compared to women with congruent HC use. A similar effect has also been hypothesized for general relationship satisfaction, and recent findings suggest that the association between HC incongruency and women's general relationship satisfaction is moderated by third-party ratings of facial attractiveness of the women's male partners. Using a large convenience sample (N = 948) of Finnish women, we attempted to replicate previously reported findings but found no support for the HC congruency hypothesis, despite excellent statistical power (≥98.7%) to detect previously reported effect sizes. Instead, after dividing our sample into four groups based on HC congruency/incongruency, we found that the largest differences in jealousy, sexual satisfaction, and relationship satisfaction scores tended to be found between women who were consistent HC users and consistent non-users (i.e., between women with different kinds of congruent HC use). We also detected a significant main effect of current HC use on jealousy. We conclude that HC congruency effects reported in previous studies may have spuriously arisen from unequal distributions of current HC users within congruent and incongruent HC user groups. 相似文献