全文获取类型
收费全文 | 13718篇 |
免费 | 1204篇 |
国内免费 | 11篇 |
专业分类
14933篇 |
出版年
2023年 | 48篇 |
2022年 | 130篇 |
2021年 | 234篇 |
2020年 | 144篇 |
2019年 | 190篇 |
2018年 | 210篇 |
2017年 | 174篇 |
2016年 | 341篇 |
2015年 | 576篇 |
2014年 | 604篇 |
2013年 | 808篇 |
2012年 | 975篇 |
2011年 | 996篇 |
2010年 | 641篇 |
2009年 | 567篇 |
2008年 | 845篇 |
2007年 | 875篇 |
2006年 | 786篇 |
2005年 | 760篇 |
2004年 | 777篇 |
2003年 | 722篇 |
2002年 | 668篇 |
2001年 | 155篇 |
2000年 | 97篇 |
1999年 | 149篇 |
1998年 | 167篇 |
1997年 | 123篇 |
1996年 | 118篇 |
1995年 | 107篇 |
1994年 | 94篇 |
1993年 | 109篇 |
1992年 | 107篇 |
1991年 | 71篇 |
1990年 | 83篇 |
1989年 | 63篇 |
1988年 | 75篇 |
1987年 | 77篇 |
1986年 | 57篇 |
1985年 | 80篇 |
1984年 | 82篇 |
1983年 | 80篇 |
1982年 | 105篇 |
1981年 | 95篇 |
1980年 | 90篇 |
1979年 | 56篇 |
1978年 | 53篇 |
1977年 | 55篇 |
1976年 | 53篇 |
1974年 | 49篇 |
1973年 | 57篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
52.
53.
Anthony J. Zera 《Biochemical genetics》1981,19(7-8):797-812
Variation at the -glycerophosphate dehydrogenase (-Gpdh; EC 1.1.1.8) locus was surveyed in 11 species of waterstriders (Gerridae: Hemiptera) and five other species of aquatic Hemiptera. Species of waterstriders exhibited considerable inter- and intraspecific variation in degree of winglessness. Average heterozygosity (0.401±0.090) and average number of observed electromorphs (5.36±0.96) for the 11 gerrid species were well above values reported for nearly all other insect species surveyed to date. Wing-monomorphic and wing-polymorphic species did not differ in average -Gpdh heterozygosity. Of the three wing-polymorphic species surveyed geographically, two species exhibited marked variation in wing-morph frequencies but homogeneous -Gpdh allele frequencies. The third species exhibited geographically homogeneous -Gpdh and wing-morph frequencies, but no significant association between -Gpdh phenotype and wing morph was observed in any surveyed population. These results are consistent with hypotheses evoking either relaxed purifying selection at the -Gpdh locus in species of Gerridae due to the apparent reduced importance of flight, or selective maintenance of common -Gpdh electromorphs.This work was supported by NSF Grant DEB 76-20967 to Alan H. Brush, funds from the Research Foundation of the University of Connecticut to Carl W. Schaefer, and USPHS Grant GM 21133 to Richard K. Koehn. 相似文献
54.
Methyl 2,6-dideoxy-α-L-arabino-hexopyranoside (6) was prepared from L-rhamnose in five steps. Hydrolysis of6 with 50% aqueous acetic acid gave 2,6-dideoxy-L-arabino-hexopyranose. Treatment of 3,4-di-O-acetyl-L-rhamnal with acetic acid in the presence of acetic anhydride and 2% sulfuric acid afforded 1,2,3-tri-O-acetyl-2,6-dideoxy-L-arabino-hexopyranose in 65% yield. Selective benzoylation and subsequent mesylation of 6 afforded methyl 3-O-benzoyl-2,6-dideoxy-4-O-mesyl-α-L-arabino-hexopyranoside, which was treated with sodium benzoate and sodium azide in hexamethylphosphoric triamide to give the corresponding 3,4-dibenzoyl 9 and 4-azido 11 analogs. Hydrogenation and N-acetylation of 11 afforded the 4-acetamido derivative 12. Deprotection of 9 and 12 gave 2,6-dideoxy-L-lyxo-hexopyranose and 4-acetamido-2,4,6-trideoxy-L-lyxo-hexopyranose, which were characterized as their peracetates. The free and corresponding peracetylated derivatives were assayed for their ability to inhibit the growth of P388 leukemia cells in culture. Although the free sugars did not inhibit the replication of these tumor cells under the conditions employed, their peracetylated derivatives demonstrated significant activity. 相似文献
55.
Selective acid-catalysed methanolysis of 2,3,2′,3′-tetra-O-benzyl-4,6:4′,6′-di-O-benzylidene-α,α-trehalose yielded the monobenzylidene derivative, which was converted into the 4,6-dimesylate. Selective nucleophilic displacement of the primary sulphonyloxy group then gave 2,3-di-O-benzyl-6-deoxy-6-fluoro-4-O-mesyl-α-d-glucopyranosyl 2,3-di-O-benzyl-4,6-O-benzylidene-α-d-glucopyranoside. Removal of the protecting groups then yielded 6-deoxy-6-fluoro-α,α-trehalose. In addition, 6-deoxy-6-fluoro-4-O-mesyl-α,α-trehalose and a derivative of 4-chloro-4,6-dideoxy-6-fluoro-α-d-galactopyranosyl α-d-glucopyranoside were also prepared from the same substrate. Iodide displacement of 2,3-di-O-benzyl-4,6-di-O-mesyl-α-d-glucopyranosyl 2,3-di-O-benzyl-4,6-di-O-mesyl-α-d-glucopyranoside afforded the 6-iodide and 6,6′-di-iodide in yields of 31 and 36%, respectively. Similarly, the 6-azide and 6,6′-diazide were isolated in yields of 17 and 21%, respectively. 相似文献
56.
The relative proportions of carbonyl, O-acetyl, and O-(methylthio)methylsugars resulting from the partial oxidation of methyl α-D-glucopyranoside with methyl sulphoxide and acetic anhydride have been investigated@ the preparation of the 2- and 6-(methylthio)methyl ethers of methyl α-D-glucopyranoside is described. 相似文献
57.
58.
59.
2-acetamido-2-deoxyaldohexopyranose polyacetates are transformed by the action of phosphorus pentachloride into 2-tetrachloroethylideneamino derivatives, the trans-2-acetamido-l-acetate system reacting more rapidly than the cis. A 1-acetamido-pyranosyl polyacetate afforded the 1-tetrachloroethylideneamino derivative and 2-O-trichloroacetyl-β-D-glucopyranosyl chloride. The latter was also observed, amongst other products, from the reaction of β-D-glucopyranosyl azide tetra-acetate with phosphorus pentachloride. Similar reactions on acetamidocyclohexane and its 2-acetoxy derivative afforded dichloroacetamido, trichloroacetamido, and tetrachloroethylideneamino derivatives. Likewise, 1-acetamido-2-acetoxyethane gave the 1-dichloroacetamido derivative. 相似文献
60.