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排序方式: 共有135条查询结果,搜索用时 31 毫秒
31.
Influence of Various Factors on the Survival of Lactobacillus leichmannii during Freezing and Thawing 总被引:1,自引:1,他引:0
Elzbieta Johannsen 《Journal of applied microbiology》1972,35(3):415-421
S ummary : The influence of the age and activity of bacteria, their concentration in the protective medium, the pH value of the medium, the temperature of thawing, and the time of storage on the survival of L. leichmannii during freezing and thawing has been investigated. 相似文献
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David G. Alberg Thomas B. Poulsen Søren Bertelsen Kasper L. Christensen Rune D. Birkler Mogens Johannsen Karl Anker Jørgensen 《Bioorganic & medicinal chemistry letters》2009,19(14):3888-3891
The aldol reaction of the endogeneous compounds acetone and methylglyoxal has been studied using organocatalysis in relation to biologically relevant non-enzymatic reactions. Under preparative conditions, 3-hydroxy-2,5-hexadione, known as Henze’s ketol, is formed in high yield and with enantioselectivities up to 88% ee. Furthermore, Henze’s ketol is also formed under simulated physiological conditions at micromolar scale, indicating that this reaction might take place in living organisms. 相似文献
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Matthias May Sabine Brookman-May Bernd Hoschke Christian Gilfrich Friederike Kendel Susann Baxmann Stefan Wittke Stephan T. Kiessig Kurt Miller Manfred Johannsen 《Cancer immunology, immunotherapy : CII》2010,59(5):687-695
About 30% of renal cell carcinomas (RCC) will develop recurrence after surgery. Despite evidence for a significantly improved
survival by autologous tumour cell vaccination therapy, the procedure has not become standard. Between August 1993 and December
1996, 1,267 RCC patients undergoing radical nephrectomy in 84 German hospitals were subsequently treated by autologous tumour
cell vaccination therapy. The study group comprised 692 patients with complete follow-up (stages pT2-3, pNx-2, M0 based on
the TNM classification, 4th edition). Subsequent propensity-score matching according to 7 defined criteria with 861 control
patients undergoing nephrectomy alone without adjuvant treatment at the Carl-Thiem-Hospital Cottbus, resulted in 495 matched
pairs. Overall and stage-specific survival rates were analysed after a median follow-up of 131 months. The 5- and 10-year
overall survival (OS) rates were 80.6 and 68.9% in the vaccine group and 79.2 and 62.1% in the control group (p = 0.066). Patients with pT3 stage RCC revealed 5- and 10-year OS rates of 71.3 and 53.6% in the study group and 65.4 and
36.2% in the control group (p = 0.022). In multivariable analysis, patients in the vaccine group showed a significantly improved survival both in the whole
study group (HR = 1.28, p = 0.030) and in the subgroup presenting with pT3 stage tumours (HR = 1.67, p = 0.011). Adjuvant treatment with autologous vaccination therapy resulted in a significantly improved overall survival in
pT3 stage RCC patients, suggesting benefit especially in this subgroup. However, controlled clinical trials integrating the
recent TNM classification and further risk constellations are required to define additional patient groups that may derive
benefit from this treatment. 相似文献
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The combination of the simulated moving bed (SMB) technique with supercritical fluid chromatography (SFC) leads to a process with unique features. Besides the known advantages of the SMB process, the use of supercritical carbon dioxide as the mobile phase offers the advantages of reduction in organic solvents and an easy eluent/solute separation. Because of the low viscosity and high diffusion coefficients of supercritical fluids, a high efficiency is possible. The steps of process development for SMB SFC are presented using the separations of the bi-naphthol enantiomers and phytol isomers as examples. The development of a packed column SFC method at an analytical scale is shown for the separation of the bi-naphthol enantiomers on a chiral stationary phase and CO(2) with a modifier as the mobile phase. The influence of the modifier, modifier content, and column configuration on productivity of the SMB SFC process was investigated by simulation. The first set of experiments was performed in the SMB separation of phytol isomers at low concentration to test the feasibility of the SMB SFC high purity separation of the binary mixtures. In the second set of experiments, the productivity of the process was increased by increasing the feed concentration up to 54 grams feed per liter stationary phase (SP) and hour (g(feed)/l(SP) h). 相似文献
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Martin Sénéchal Neil M. Johannsen Damon L. Swift Conrad P. Earnest Carl J. Lavie Steven N. Blair Timothy S. Church 《PloS one》2015,10(8)