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Germain Nicolas Herwegh Stéphanie Hatzfeld Anne-Sophie Bocket Laurence Prévost Brigitte Danzé Pierre-Marie Marchetti Philippe 《Cell and tissue banking》2021,22(3):511-518
Cell and Tissue Banking - Background The COVID-19 pandemic has altered organ and tissue donations as well as transplantation practices. SARS-CoV-2 serological tests could help in the selection of... 相似文献
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Circulating Cell-Free DNA from Colorectal Cancer Patients May Reveal High KRAS or BRAF Mutation Load
Florent Mouliere Safia El Messaoudi Celine Gongora Anne-Sophie Guedj Bruno Robert Maguy Del Rio Franck Molina Pierre-Jean Lamy Evelyne Lopez-Crapez Muriel Mathonnet Marc Ychou Denis Pezet Alain R Thierry 《Translational oncology》2013,6(3):319-IN8
Our data might suggest a very high variation in the proportion of malignant cells in colorectal tumors and/or low tumor cell clonogenicity. However, the direct relationship between these data and the proportion of malignant cells is currently uncertain as the mechanism of ccfDNA release determines the yield (necrosis, apoptosis, or active release). Therefore, interindividual comparison of the proportion of mutant allele determined from circulating DNA could appear somewhat more difficult to interpret; however, this parameter could be an efficient biomarker for monitoring or following up CRC patients and could be combined with size fraction analysis, as demonstrated in this study, to provide a deeper examination toward this goal. 相似文献
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