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61.
Bertoja AZ Zenclussen ML Casalis PA Sollwedel A Schumacher A Woiciechowsky C Volk HD Zenclussen AC 《Cellular immunology》2005,238(2):97-102
Leukocyte migration into inflamed tissues comprises dynamic interactions between immune and endothelial cells through events controlled by adhesion molecules, e.g., P- and E-selectins, which mediate Th1 cells recruitment after injury. Since miscarriage is known to be a Th1 event and selectins are expressed at the murine foetal-maternal interface, the purpose of our study was to investigate whether blocking P- and E-selectins before implantation could inhibit Th1 migration into the foetal-maternal interface and thus prevent foetal rejection. DBA/2J-mated CBA/J females were treated with monoclonal antibodies (mAbs) against P-selectin or with both, anti-P- and anti-E-selectins combined on days 2 and 4 of pregnancy. PBS-treated females served as controls. Our data revealed a significant improvement in pregnancy outcome in both treated groups compared to the control, which is due to the effectiveness of the mAb against P-selectin, since the treatment with anti-E-selectin alone could not prevent abortion. We further observed that there was diminished Th1 cytokine production by decidual immune cells in all treated groups in comparison to the controls. Our data first confirm the important role of P-selectin in mediating the extravasation of abortive cells, while opening new therapeutic opportunities. 相似文献
62.
Annarosa Bernicchia 《Plant biosystems》2013,147(4-6):829-841
Abstract Vengono presentate in questo lavoro alcune specie rare, spesso non segnalate prima in Italia, come: Lindtneria trachyspora (Bourdot & Galzin) Pilat, Oligoporus rancidus (Bres.) Gilb. & Ryvarden, Sistotrema muscicola (Pers.) S. Lundell, Trechispora hymenocystis (Berk. & Broome) K.H. Larss. e Fomitopsis labyrinthica Bernicchia & Ryvarden, una specie recentemente descritta come nuova, ritrovata sull'Appennino settentrionale. 相似文献
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Giovanni De Marco Annarosa Lomartire Giorgia Mandili Elisa Lupino Barbara Buccinnà Cristina Ramondetti Cristina Moglia Francesco Novelli Marco Piccinini Michael Mostert Maria Teresa Rinaudo Adriano Chiò Andrea Calvo 《Biochimica et Biophysica Acta (BBA)/Molecular Cell Research》2014
Accumulation of transactive response DNA binding protein (TDP-43) fragments in motor neurons is a post mortem hallmark of different neurodegenerative diseases. TDP-43 fragments are the products of the apoptotic caspases-3 and -7. Either excessive or insufficient cellular Ca2+ availability is associated with activation of apoptotic caspases. However, as far as we know, it is not described whether activation of caspases, due to restricted intracellular Ca2+, affects TDP-43 cleavage. Here we show that in various cell lineages with restricted Ca2+ availability, TDP-43 is initially cleaved by caspases-3 and -7 and then, also by caspases-6 and -8 once activated by caspase-3. Furthermore, we disclose the existence of a TDP-43 caspase-mediated fragment of 15 kDa, in addition to the well-known fragments of 35 and 25 kDa. Interestingly, with respect to the other two fragments this novel fragment is the major product of caspase activity on murine TDP-43 whereas in human cell lines the opposite occurs. This outcome should be considered when murine models are used to investigate TDP-43 proteinopathies. 相似文献
64.
Massimo Olivotto Annarosa Arcangeli Marcello Carl Enzo Wanke 《BioEssays : news and reviews in molecular, cellular and developmental biology》1996,18(6):495-504
Membrane proteins possess certain features that make them susceptible to the electric fields generated at the level of the plasma membrane. A reappraisal of cell signalling, taking into account the protein interactions with the membrane electrostatic profile, suggests that an electrical dimension is deeply involved in this fundamental aspect of cell biology. At least three types of potentials can contribute to this dimension: (1) the potential across the compact layer of water adherent to membrane surfaces; this potential is affected by classical inducers of cell differentiation, like dimethylsulfoxide and hexamethylenebisacetamide; (2) the potential across the Gouy-Chapman double layer, which accounts for the effects of extracellular cations in the modulation of differentiation; and (3) the resting potential. This last potential and its governing ion currents can be exploited in localised mechanisms of cell signalling centred on the functional association of integrin receptors with ion channels. 相似文献
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Dr. Annarosa Ciofi Luzzatto 《Cell and tissue research》1981,215(1):133-142
Summary Rat hepatocyte differentiation between day 12 and 19 of fetal life was studied by electron microscopy. The cytoplasmic structures involved in synthetic and secretory function, i.e., rough endoplasmic reticulum and Golgi apparatus, appear to be the first to differentiate, and their development is probably related to the secretion of different kinds of plasma proteins. The cytoplasmic organelles involved in other hepatic functions develop later: lysosomes from day 15, peroxysomes, glycogen rosettes and smooth endoplasmic reticulum still later. However, the morphological differentiation of bile canaliculi begins from day 12.This work was supported in part by a grant from C.N.R. n. 78.02265.04 相似文献