全文获取类型
收费全文 | 32313篇 |
免费 | 1720篇 |
国内免费 | 9篇 |
出版年
2023年 | 143篇 |
2022年 | 342篇 |
2021年 | 653篇 |
2020年 | 414篇 |
2019年 | 539篇 |
2018年 | 777篇 |
2017年 | 640篇 |
2016年 | 1032篇 |
2015年 | 1395篇 |
2014年 | 1597篇 |
2013年 | 2018篇 |
2012年 | 2281篇 |
2011年 | 2234篇 |
2010年 | 1394篇 |
2009年 | 1200篇 |
2008年 | 1625篇 |
2007年 | 1559篇 |
2006年 | 1447篇 |
2005年 | 1330篇 |
2004年 | 1181篇 |
2003年 | 1179篇 |
2002年 | 980篇 |
2001年 | 391篇 |
2000年 | 323篇 |
1999年 | 308篇 |
1998年 | 207篇 |
1992年 | 280篇 |
1991年 | 273篇 |
1990年 | 237篇 |
1989年 | 255篇 |
1988年 | 280篇 |
1987年 | 272篇 |
1986年 | 252篇 |
1985年 | 285篇 |
1984年 | 230篇 |
1983年 | 203篇 |
1979年 | 262篇 |
1978年 | 182篇 |
1977年 | 158篇 |
1976年 | 158篇 |
1975年 | 185篇 |
1974年 | 277篇 |
1973年 | 275篇 |
1972年 | 265篇 |
1971年 | 248篇 |
1970年 | 269篇 |
1969年 | 250篇 |
1968年 | 189篇 |
1967年 | 197篇 |
1966年 | 174篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
141.
E Wielgus-Serafińska G Nowaczyk-Dura M Kamiński 《Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society》1988,26(1):11-18
Most of the biological processes in the living organisms of both animals and man are known to be of rhythmical nature. Variability of enzymatic activity in circadian cycle depends on many factors among other on age, sexual maturity, diet as well as medication. The results obtained in our studies indicate, that the activity changes of acid phosphatase and ATP-ase Mg++ dependent in the liver of all the examined age groups were of 24 hour circadian rythm. As to the acid phosphatase activity the results of this experiments showed that in circadian cycle in all examined age groups there is only one peak of elevated activity. ATP-ase Mg++ dependent showed two activity peaks appearing at the same hour both in 30 and 60 days old animals. It should be noticed that the activities of ATP-ase Mg++ dependent in 100 day old animals were two times higher than in 30 and 60 days old rats. 相似文献
142.
Piotr Borsuk Marek Gniadkowski Ewa Bartnik Piotr P. Stępień 《Journal of molecular evolution》1988,28(1-2):125-130
Summary AllAspergillus nidulans 5S rRNA pseudogenes known so far are the result of integration of an approx. 0.2-kbp-long DNA sequence into the 5S rRNA genes. This sequence, called block C, is present in at least five copies in theA. nidulans genome and seems to be associated either with 5S rRNA genes or pseudogenes. In contrast to the 78% sequence conservation of the C-block in pseudogenes, the truncated 5 halves of the pseudogenes are very highly conserved (96.9–100%). We postulate that the 5S rRNA pseudogenes are still a subject of concerted evolution. The C-block sequence shows similarity to the switch region of the mouse heavy chain immunoglobulin gene. A characteristic motif GGGTGAG is repeated several times in both sequences; the sequence conservation is 63%. 相似文献
143.
144.
145.
146.
147.
Mary K. Vaughan Damon C. Herbert George M. Vaughan Frank J. Weaker Anna I. Esquifino Russel J. Reiter 《Chronobiology international》1988,5(2):107-114
In young adult male rats bearing a donor anterior pituitary gland grafted for 3 weeks under a kidney capsule, serum prolactin (PRL) concentrations were elevated and exhibited a rhythm with the highest values in the light phase. Serum PRL in control animals did not exhibit a significant rhythm. Eutopic pituitary PRL content, manifesting a biphasic (12-hr) rhythm with crests during the day and night in controls, exhibited a similar pattern in grafted rats though an overall reduction in pituitary PRL content was seen in the grafted animals. Neither the normal biphasic serum testosterone rhythm nor the normal 24-hr rhythm (nocturnal surge) of pineal N-acetyltransferase activity and melatonin content were altered in the hyperprolactinemic rats. Serum thyroxine (T4) and triiodothyronine (T3) and their free indices (FT4 I, FT3 I) and serum thyrotropin (TSH) were highest during the day in controls and grafted rats and a 12-hr rhythmic component was detected in data for these variables. In the grafted animals, the 12-hr component was reflected in an additional peak at night detectable by testing of means. The overall serum T4 FT4 I, and TSH levels were lower in grafted rats though overall T3 and FT3I levels did not differ between grafted and controls. T3 uptake (T3 U) values were similar between controls and grafted rats, in both cases exhibiting a fall during the night. Changes in serum thyronines could not be explained by changes in serum binding as assessed by the T3U3 and thus may represent changes in thyroidal secretion of T4. The rhythm in serum PRL of grafted rats suggests the presence of rhythmic circulating factor(s) capable of influencing ectopic lactotrophs. The reduced eutopic pituitary PRL content suggests a role for PRL in influencing eutopic lactotrophs in the pituitary-grafted hyperprolactinemic male rat model. Though circulating testosterone and pineal melatonin synthesis were not altered in this model, thyroid function appeared to be so. 相似文献
148.
Anna Maria Greco Pasquale Gambardella Raffaella Sticchi Diego D'aponte Pietro De Franciscis 《Chronobiology international》1988,5(3):217-225
Circadian rhythms of serotonin (5HT), its precursors tryptophan (TP) and 5-hydroxy-tryptophan (5HTP) and its acid catabolite 5-hydroxy-indoleacetic acid (5HIAA), were determined in the hypothalamus of control rats and rats which had been treated continuously with subcutaneous imipramine (10 mg/kg/day) for 2 weeks.
Rats were individually housed and entrained to LD12:12. Controls showed the 5HT and TP peaks in the light and dark periods respectively, as reported in the literature, but no inverted correlation (antiphase) between SHT and 5HIAA rhythms.
Imipramine significantly modified circadian rhythm characteristics: the 5HT acrophase was advanced, that of TP and 5HIAA was delayed. Imipramine also significantly increased hypothalamic SHT and TP concentrations. 相似文献
Rats were individually housed and entrained to LD12:12. Controls showed the 5HT and TP peaks in the light and dark periods respectively, as reported in the literature, but no inverted correlation (antiphase) between SHT and 5HIAA rhythms.
Imipramine significantly modified circadian rhythm characteristics: the 5HT acrophase was advanced, that of TP and 5HIAA was delayed. Imipramine also significantly increased hypothalamic SHT and TP concentrations. 相似文献
149.
Molecular genetic analysis in the diagnosis of lymphoma in fine needle aspiration biopsies. II. Lymphomas versus nonlymphoid malignant tumors 总被引:1,自引:0,他引:1
J Lubiński M Chosia K Huebner 《Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology》1988,10(6):399-404
The configurations of immunoglobulin genes and T-cell receptor beta chain genes were analyzed by Southern blotting in DNA derived from nonlymphoid malignant tumors and lymphomas. Gene rearrangements were not detected in any of the 35 cases of nonlymphoid malignant tumors. On the contrary, they were shown in all 14 cases of non-Hodgkin's lymphomas, 2 of 3 cases of Hodgkin's disease and 2 cases diagnosed as non-Hodgkin's lymphoma or angioimmunoblastic lymphadenopathy. The differentiation by light microscopy between lymphoma and nonlymphoid malignant tumors was a diagnostic problem in five cases; the molecular genetic analysis of DNA was contributory in all five diagnostically difficult aspirates. By gene rearrangement studies, the diagnosis of lymphoma was confirmed in two cases and nonlymphoid malignant tumors were accurately indicated in aspirates diagnosed finally as rhabdomyosarcoma (one case) and carcinoma (two cases). 相似文献
150.
J. B. Warchol Ch. Pilgrim W. J. Ginda R. Brelińska 《Histochemistry and cell biology》1988,88(3-6):571-573
Summary Wistar rats were injected intraperitoneally with 2-(14C)deoxyglucose and their thymuses were processed for thaw-mount autoradiography after 5, 10 or 35 min. Highest levels of radioactivity were demonstrated in the thymic medulla (5-fold higher than in the cortex). Scanning of autoradiograms for regional differences in grain densities indicated particularly intense glucose utilization in the cortico-medullary zone. Differences in glucose utilization between individual thymic zones seem to reflect differences in cellular composition, i. e., ratio of stroma cells to thymocytes.Dedicated to Professor Dr. T.H. Schiebler on the occasion of his 65th birthday 相似文献