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131.
H N Bhargava 《Life sciences》1981,29(19):1945-1949
Repeated intraventricular injections of human β-endorphin to rats every eight hours for three days resulted in the development of super-sensitivity of brain dopamine receptors as evidenced by an enhanced locomotor activity response to apomorphine, a dopamine receptor agonist. Daily subcutaneous injections of Pro-Leu-Gly-NH2 or its cyclic analog, cyclo (Leu-Gly) blocked the enhanced apomorphine-induced stimulation of locomotor activity in β-endorphin treated rats. Thus, the development of brain dopamine receptor supersensitivity induced by chronic β-endorphin administration may be regulated by the hypothalamic peptides. 相似文献
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135.
G. B. Chheda J. G. Antkowiakt H. Takitat A. K. Bhargava H. A. Tworek 《Nucleosides, nucleotides & nucleic acids》2013,32(3):441-442
Abstract Elevation of 5-carbamoylmethyluridine in the urines of non-small lung carcinoma patients suggests that this nucleoside may be used as an indicator of tumor burden for these patients. 相似文献
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Two temperature-sensitive autolysis-defective mutants of Escherichia coli were isolated and shown to be resistant to lysis induced by seminalplasmin, an antimicrobial protein from bovine seminal plasma, as well as to lysis induced by ampicillin, D-cycloserine and nocardicin, at 37 or 42 degrees C but not at 30 degrees C. The mutants were, however, sensitive to inhibition of RNA synthesis by seminalplasmin even at the nonpermissive temperature. Temperature-resistant revertants of the mutants were sensitive to lysis induced by the various antibiotics at 37 or 42 degrees C. The mutations in both strains were mapped at 58 min on the E. coli linkage map. The lysis resistance of the mutants was phenotypically suppressed by the addition of NaCl. Partial suppression of the lysis-resistant phenotype was also observed in a relA genetic background. 相似文献
138.
The binding of [3H] DAMGO, a highly selective ligand for mu-opiate receptors, to membranes of discrete brain regions and spinal cord of 10 week old spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats was determined. The brain regions examined were hypothalamus, amygdala, hippocampus, corpus striatum, pons and medulla, midbrain and cortex. [3H] DAMGO bound to membranes of brain regions and spinal cord at a single high affinity site. The receptor density (Bmax value) and apparent dissociation constant (Kd value) of [3H] DAMGO to bind to membranes of hippocampus, corpus striatum, pons and medulla, cortex and spinal cord of WKY and SHR rats did not differ. The Bmax value of [3H] DAMGO in membranes of hypothalamus and midbrain of SHR rats was significantly higher than in WKY rats but the Kd values in the two strains did not differ. On the other hand, the Bmax value of [3H] DAMGO in membranes of amygdala of SHR rats was lower than that of WKY rats but the Kd values in the two strains were similar. It is concluded that SHR rats have higher density of mu-opiate receptors in hypothalamus and midbrain but lower density in amygdala in comparison with WKY rats, and that such differences in the distribution of mu-opiate receptors may be related to the elevated blood pressure in SHR rats. 相似文献
139.
Yuan LI Ansamma Joseph Madhu M. Bhargava Eliot M. Rosen Toshikazu Nakamura Itzhak Goldberg 《In vitro cellular & developmental biology. Animal》1992,28(5):364-368
Summary We investigated the effects of human placental scatter factor (hSF), mouse scatter factor (mSF) and recombinant human hepatocyte
growth factor (HGF) on motility and morphology of individual Madin-Darby canine kidney cells using a computerized cell tracking
system. All three factors increased the velocity of individual cells and the ratio of moving to stationary cells. Similarly,
all three factors caused changes in morphologic features of cells, leading to increased area, flatness, and polarity. Increases
in area and flatness but not polarity were slightly greater with HGF than with hSF or mSF. These results suggest that SFs
and HGF have similar effects on motility and morphology of isolated epithelial cells. 相似文献
140.
T11TS immunotherapy repairs PI3K‐AKT signaling in T‐cells: Clues toward enhanced T‐cell survival in rat glioma model 下载免费PDF全文