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91.
B. S. Dahiya R. S. Waldia L. S. Kaushik I. S. Solanki 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1984,68(6):525-529
Summary Four F3 populations of chickpea (Cicer arietinum L.) were simultaneously evaluated for yield in an F3 yield trial and in single plant progeny rows. Ten high yielding, 10 low yielding and 10 randomly sampled lines, along with 10 lines visually selected for yield from the progeny rows, were retained for further evaluation. The lines from each of the four selection groups in each population were bulked and evaluated in a replicated yield trial at three locations and four environments. The bulk of visually selected lines was not superior in yield to the bulk of randomly sampled lines at all locations. The present results indicate that an early generation yield testing selection procedure is more efficient than visual selection for yield improvements in chickpea. 相似文献
92.
D L Solanki 《BMJ (Clinical research ed.)》1983,287(6394):725-726
93.
The phenotypic spectrum of GLI3 morphopathies includes autosomal dominant preaxial polydactyly type-IV and postaxial polydactyly type-A/B; No phenotype prediction from the position of GLI3 mutations. 总被引:4,自引:0,他引:4
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U Radhakrishna D Bornholdt H S Scott U C Patel C Rossier H Engel A Bottani D Chandal J L Blouin J V Solanki K H Grzeschik S E Antonarakis 《American journal of human genetics》1999,65(3):645-655
Functional characterization of a gene often requires the discovery of the full spectrum of its associated phenotypes. Mutations in the human GLI3 gene have been identified in Greig cepalopolysyndactyly, Pallister-Hall syndrome (PHS), and postaxial polydactyly type-A (PAP-A). We studied the involvement of GLI3 in additional phenotypes of digital abnormalities in one family (UR003) with preaxial polydactyly type-IV (PPD-IV), three families (UR014, UR015, and UR016) with dominant PAP-A/B (with PPD-A and -B in the same family), and one family with PHS. Linkage analysis showed no recombination with GLI3-linked polymorphisms. Family UR003 had a 1-nt frameshift insertion, resulting in a truncated protein of 1,245 amino acids. A frameshift mutation due to a 1-nt deletion was found in family UR014, resulting in a truncated protein of 1,280 amino acids. Family UR015 had a nonsense mutation, R643X, and family UR016 had a missense mutation, G727R, in a highly conserved amino acid of domain 3. The patient with PHS had a nonsense mutation, E1147X. These results add two phenotypes to the phenotypic spectrum caused by GLI3 mutations: the combined PAP-A/B and PPD-IV. These mutations do not support the suggested association between the mutations in GLI3 and the resulting phenotypes. We propose that all phenotypes associated with GLI3 mutations be called "GLI3 morphopathies," since the phenotypic borders of the resulting syndromes are not well defined and there is no apparent genotype-phenotype correlation. 相似文献
94.
The quantitative determination of Macrophomina phaseolina population in an arid soil was carried out utilizing a selective medium. The population of the fungus increased under continuous
monocropping with a susceptible host, but considerable reduction was recorded with crop rotation or a change in crop sequence.
The effects of fungi, bacteria, actinomycetes, total microbial population, minimum and maximum soil temperature on the survival
of M. phaseolina population were studied in the absence of a crop at different soil depths. Highest population and survival rates were recorded
at 0–5 cm soil depth. Correlation and path coefficient analyses were carried out to determine the role of individual factors
influencing M. phaseolina population. In winter months, low temperature and high actinomycete population were found to be the major factors governing
the reduction of the population of M. phaseolina. 相似文献
95.
Colah R Surve R Wadia M Solanki P Mayekar P Thomas M Gorakshakar A Dastur A Mohanty D 《Genetic testing》2008,12(2):181-185
AIM: Premarital screening for beta-thalassemia is not widely acceptable in India; hence, we evaluated the effectiveness of antenatal screening and counseling over 7 years. METHODS: 61,935 pregnant women were screened using the single-tube osmotic fragility test during their first antenatal visit. Individuals who were positive were investigated further for diagnosis of beta-thalassemia and other abnormal hemoglobins. Spouses of carrier women were tested whenever available. Couples at risk were given the option of prenatal diagnosis. RESULTS: Only 19% of the women registered at the antenatal clinic in the first trimester of pregnancy, and 14% of the women were positive per the osmotic fragility test; 1020 beta-thalassemia heterozygotes and 213 women with other hemoglobinopathies were identified, majority being in the second and third trimesters. Seven hundred and thirteen (69%) of their husbands could be tested, and 37 couples at risk were identified. Only 15 couples had a prenatal diagnosis done. Four couples with affected fetuses opted for termination of pregnancy. The remaining couples either did not respond after counseling or the pregnancies were advanced for prenatal intervention. CONCLUSION: This first large study shows that antenatal screening is acceptable in India; however, awareness generation is still a primary requisite to make women register early at antenatal clinics and bring their spouses for screening when required. 相似文献
96.
Kaushik A Khan R Solanki PR Pandey P Alam J Ahmad S Malhotra BD 《Biosensors & bioelectronics》2008,24(4):676-683
Iron oxide (Fe(3)O(4)) nanoparticles prepared using co-precipitation method have been dispersed in chitosan (CH) solution to fabricate nanocomposite film on indium-tin oxide (ITO) glass plate. Glucose oxidase (GOx) has been immobilized onto this CH-Fe(3)O(4) nanocomposite film via physical adsorption. The size of the Fe(3)O(4) nanoparticles estimated using X-ray diffraction (XRD) pattern and transmission electron microscopy (TEM) has been found to be approximately 22 nm. The CH-Fe(3)O(4) nanocomposite film and GOx/CH-Fe(3)O(4)/ITO bioelectrode have been characterized using UV-visible and Fourier transform infrared (FTIR) spectroscopic and scanning electron microscopy (SEM) techniques, respectively. This GOx/CH-Fe(3)O(4)/ITO nanocomposite bioelectrode has response time of 5s, linearity as 10-400 mgdL(-1) of glucose, sensitivity as 9.3 microA/(mgdLcm(2)) and shelf life of about 8 weeks under refrigerated conditions. The value of Michaelis-Menten (K(m)) constant obtained as 0.141 mM indicates high affinity of immobilized GOx towards the substrate (glucose). 相似文献
97.
Solanki Vandana Sharma Saroj Tiwari Vishvanath 《International journal of peptide research and therapeutics》2021,27(2):1177-1195
International Journal of Peptide Research and Therapeutics - Klebsiella pneumoniae is a Gram-negative opportunistic pathogen that causes bacteremia, meningitis, endocarditis, cellulitis, urinary... 相似文献
98.
Wafer thickness reduction is the main trend for cost reduction of crystalline silicon (c-Si) solar cells. For better light trapping in lower thickness wafers where traditional texturization method may not be promising, alternative techniques are being explored. Here, reflection minimization using silver ultra thin film sandwiched between silicon nitride (SiNx) antireflection coating (ARC) layers on c-Si substrate is reported. SiNx ARC layers were deposited by plasma-enhanced chemical vapor deposition (PECVD) and silver ultra thin film by e-beam evaporation; 41 % reflection reduction for silver ultra thin film sandwiched in SiNx ARC layers as compared to standard 80 nm thin SiNx ARC on c-Si substrate is shown. The sandwiched structure gives 8.1 % weighted total reflectance for wavelength range of 300–1,200 nm as compared to standard 80-nm SiNx-based ARC which gives 13.8 %. Also, comparison of this Ag ultra thin film-based sandwiched geometry is done with randomly distributed nanoparticle (NP)-based ARC geometry. It is shown that optically, the sandwiched Ag ultra thin film-based device geometry is more promising than Ag NP-based device geometry and standard 80-nm SiNx-based geometry for broad wavelength range of 300–1,200 nm. 相似文献
99.
Bharti Bhatia Sanket Singh Ponia Amit Kumar Solanki Aparna Dixit Lalit C Garg 《Bioinformation》2014,10(7):401-405
Clostridium perfringens is an anaerobic pathogen known to cause vast number of diseases in mammals and birds. Various toxins and
hydrolysing enzymes released by the organism are responsible for the necrosis of soft tissues. Due to serious safety issues
associated with current vaccines against C. perfringens, there is a need for new drug or vaccine targets. C. perfringens is extremely
dependent on its host for nutrition which can be targeted for vaccine development or drug design. Therefore, it is of interest to
identify the unique transport systems used by C. perfringens involved in uptake of essential amino acids that are synthesized by the
host, so that therapeutic agents can be designed to target the specific transport systems. Use of bioinformatics tools resulted in the
identification of a protein component of the glutamate transport system that is not present in the host. Analysis of the conservation
profile of the protein domain indicated it to be a glutamate binding protein which also stimulates the ATPase activity of ATP
Binding Cassettes (ABC) transporters. Homology modelling of the protein showed two distinct lobes, which is a characteristic of
substrate binding proteins. This suggests that the carboxylates of glutamate might be stabilized by electrostatic interactions with
basic residues as is observed with other binding proteins. Hence, the homology model of this potential drug target can be
employed for in silico docking studies by suitable inhibitors. 相似文献
100.
Lohray BB Lohray VB Srivastava BK Gupta S Solanki M Pandya P Kapadnis P 《Bioorganic & medicinal chemistry letters》2006,16(6):1557-1561
A few substituted piperazinylphenyloxazolidinone compounds 6-13 having substitution on the distant nitrogen atom of piperazine ring scaffold have been synthesized and evaluated for their antibacterial activity in Gram-positive bacteria. A few compounds showed superior in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Streptococcus pyogenes than linezolid and eperezolid. 相似文献