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101.
Bharti Bhatia Sanket Singh Ponia Amit Kumar Solanki Aparna Dixit Lalit C Garg 《Bioinformation》2014,10(7):401-405
Clostridium perfringens is an anaerobic pathogen known to cause vast number of diseases in mammals and birds. Various toxins and
hydrolysing enzymes released by the organism are responsible for the necrosis of soft tissues. Due to serious safety issues
associated with current vaccines against C. perfringens, there is a need for new drug or vaccine targets. C. perfringens is extremely
dependent on its host for nutrition which can be targeted for vaccine development or drug design. Therefore, it is of interest to
identify the unique transport systems used by C. perfringens involved in uptake of essential amino acids that are synthesized by the
host, so that therapeutic agents can be designed to target the specific transport systems. Use of bioinformatics tools resulted in the
identification of a protein component of the glutamate transport system that is not present in the host. Analysis of the conservation
profile of the protein domain indicated it to be a glutamate binding protein which also stimulates the ATPase activity of ATP
Binding Cassettes (ABC) transporters. Homology modelling of the protein showed two distinct lobes, which is a characteristic of
substrate binding proteins. This suggests that the carboxylates of glutamate might be stabilized by electrostatic interactions with
basic residues as is observed with other binding proteins. Hence, the homology model of this potential drug target can be
employed for in silico docking studies by suitable inhibitors. 相似文献
102.
Lohray BB Lohray VB Srivastava BK Gupta S Solanki M Pandya P Kapadnis P 《Bioorganic & medicinal chemistry letters》2006,16(6):1557-1561
A few substituted piperazinylphenyloxazolidinone compounds 6-13 having substitution on the distant nitrogen atom of piperazine ring scaffold have been synthesized and evaluated for their antibacterial activity in Gram-positive bacteria. A few compounds showed superior in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Streptococcus pyogenes than linezolid and eperezolid. 相似文献
103.
Brijesh Kumar Srivastava Rina Soni Jayendra Z. Patel Amit Joharapurkar Nisha Sadhwani Samadhan Kshirsagar Bhupendra Mishra Vijay Takale Sunil Gupta Purvi Pandya Prashant Kapadnis Manish Solanki Harilal Patel Prasenjit Mitra Mukul R. Jain Pankaj R. Patel 《Bioorganic & medicinal chemistry letters》2009,19(9):2546-2550
A few thienyl substituted pyrazole derivatives were synthesized to aid in the characterization of the cannabinoid receptor antagonist and also to serve as potentially useful antiobesity agent. Structural requirements for selective CB1 receptor antagonistic activity of 5-thienyl pyrazole derivatives included the structural similarity with potent, specific antagonist rimonabant 1. Compound 3 has been identified as a hair growth stimulator and an antiobesity agent in animal models. 相似文献
104.
Mukherjee MB Tripathy V Colah RB Solanki PK Ghosh K Reddy BM Mohanty D 《Indian journal of human genetics》2009,15(3):114-120
The present study was undertaken to determine the extent of diversity at 12 microsatellite short tandem repeat (STR) loci in seven primitive tribal populations of India with diverse linguistic and geographic backgrounds. DNA samples of 160 unrelated individuals were analyzed for 12 STR loci by multiplex polymerase chain reaction (PCR). Gene diversity analysis suggested that the average heterozygosity was uniformly high ( >0.7) in these groups and varied from 0.705 to 0.794. The Hardy-Weinberg equilibrium analysis revealed that these populations were in genetic equilibrium at almost all the loci. The overall G(ST) value was high (G(ST) = 0.051; range between 0.026 and 0.098 among the loci), reflecting the degree of differentiation/heterogeneity of seven populations studied for these loci. The cluster analysis and multidimensional scaling of genetic distances reveal two broad clusters of populations, besides Moolu Kurumba maintaining their distinct genetic identity vis-à-vis other populations. The genetic affinity for the three tribes of the Indo-European family could be explained based on geography and Language but not for the four Dravidian tribes as reflected by the NJT and MDS plots. For the overall data, the insignificant MANTEL correlations between genetic, linguistic and geographic distances suggest that the genetic variation among these tribes is not patterned along geographic and/or linguistic lines. 相似文献
105.
106.
Microbial Inoculants with Multifaceted Traits Suppress Rhizoctonia Populations and Promote Plant Growth in Cotton 下载免费PDF全文
Radha Prasanna Balasubramanian Ramakrishnan Kunal Ranjan Siddarthan Venkatachalam Amrita Kanchan Priyanka Solanki Dilip Monga Yashbir S. Shivay Sandhya Kranthi 《Journal of Phytopathology》2016,164(11-12):1030-1042
The suppressive effects of microbial inoculants on cotton seedling mortality were assessed in Rhizoctonia solani‐infested soil. Per cent mortality ranged from 16 to 32 (60–120 days after sowing, DAS) and significant differences were recorded at 120 DAS, especially after drenching with compost tea of Azotobacter sp. and Anabaena torulosa—Trichoderma viride‐biofilmed formulations. The activity of hydrolytic enzymes was reduced in diseased root tissues due to a majority of the microbially inoculated treatments, compared with healthy root tissues. Per cent changes in the amounts of glomalin‐related soil proteins (GRSPs) were 2 to 85% greater than those of the uninoculated experimental controls. These microbial inoculants altered the rhizosphere bacterial communities as evident from the Denaturing gradient gel electrophoresis (DGGE) banding patterns and, also reduced the population of R. solani. While the copy numbers of the internal transcribed spacer (ITS) gene of R. solani in the uninoculated (infested soil) were approximately 1.47 × 1011 per g soil, they were 1.34–1.42 × 105 per g soil after the application of A. torulosa, Anabaena laxa and A. torulosa–Bacillus sp. Increases in yield (ranging from 3 to 23%) due to various microbial inoculants relative to uninoculated controls illustrated their promise as plant growth‐promoting and disease‐suppressing agents. This study illustrates the modulation of rhizosphere ecology through microbial inoculants as a mechanism of disease suppression and sustaining plant growth. 相似文献
107.
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109.
Inhibition of binding of corticotropin-(1-24)-tetracosapeptide (Synacthen) to membrane receptors of adrenal cortex by cortisol. 下载免费PDF全文
The binding of Synacthen to partially purified bovine adrenocortical plasma membranes was shown to be inhibited by cortisol. The findings suggest that cortisol is involved in a peripheral feedback mechanism for the control of its release. 相似文献
110.
Colletotrichum capsici produced protopectinase, polygalacturonase and polymethylesterase. Polymethylesterase removed 2.42 mg of methoxyl per ml of culture filtrate in 3 hrs. 相似文献