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151.
Alexandra Gaspar-Pintiliescu Elena Daniela Anton Andreea Iosageanu Daniela Berger Cristian Matei Raul-Augustin Mitran Ticuta Negreanu-Pirjol Oana Craciunescu Lucia Moldovan 《化学与生物多样性》2021,18(8):e2100293
Acid-soluble, undenatured, type I collagen (BSC) isolated, for the first time, from gilthead bream skin and the novel fabricated 3D porous wound dressing were analyzed for physicochemical and biological properties, in order to offer a safe alternative to commercial bovine collagen (BC) products. SDS-polyacrylamide analysis confirmed the purity of BSC preparation. The hydroxyproline content and temperature of denaturation of BSC were lower than those of BC, in accordance with the structural data recorded by FT-IR spectroscopy. However, certain concentrations of BSC stimulated the cell metabolism of L929 fibroblasts in a higher proportion than BC. The 3D wound dressing presented high porosity and low surface hydrophobicity that could help cell attachment and growth. The rapid biodegradation of BSC wound dressing could explain the improved in vitro cell migration and wound closure rate. In conclusion, the skin of gilthead bream from the Black Sea coast represented a valuable source for the biomedical industry, providing biocompatible, biodegradable collagen and 3D porous wound dressing, as novel material with enhanced wound healing activity. 相似文献
152.
Dinu Stefan Hosni Popotte Andreea Raluca Stefan Audrey Tesniere Aurélie Tomaszewski Paul Lesueur Jean-Louis Habrand Laurence Verneuil 《Reports of Practical Oncology and Radiotherapy》2016,21(1):76-80
A 56-year-old man with BRAFV600E melanoma and spinal metastases treated with vemurafenib and stereotactic radiation showed a partial response without neurological, skin or mucosal toxicity, 8 months after completion of this combination. This case suggests that stereotactic radiation spares normal tissues and might be safer than conventional fractionated radiation with vemurafenib. 相似文献