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51.
Biotic assemblages of insular habitats are nested when poor assemblages are subsets of richer ones. Nestedness of species
assemblages is frequent and may result from selective extinction or frequent colonization in insular habitats. It may also
be created by a nested distribution of habitats among islands or by sampling bias. We sampled 67 isolated peatlands (7–843 ha)
in southern Quebec, Canada, to measure nestedness of bird species assemblages among peatlands and assess the habitat nestedness
hypothesis. Species and microhabitat assemblages were both strongly nested among peatlands. Whether sites were ranked by species
richness, microhabitat richness or peatland area had no effect on nestedness. However, microhabitat nestedness was significantly
reduced when sites were sorted by area rather than by microhabitat richness. As expected, if bird-microhabitat associations
are responsible for the nested pattern of distribution, we found a positive correlation between the contributions of bird
species and microhabitats to individual site nestedness. Nevertheless, microhabitat assemblages were significantly less nested
than bird species assemblages, possibly because of frequent recolonization by birds or uneven sampling among sites.
Received: 12 June 1998 / Accepted: 20 September 1998 相似文献
52.
53.
Seydel U Schromm AB Brade L Gronow S Andrä J Müller M Koch MH Fukase K Kataoka M Hashimoto M Kusumoto S Brandenburg K 《The FEBS journal》2005,272(2):327-340
Lipopolysaccharide (LPS) from the outer membrane of Gram-negative bacteria belongs to the most potent activators of the mammalian immune system. Its lipid moiety, lipid A, the 'endotoxic principle' of LPS, carries two negatively charged phosphate groups and six acyl chain residues in a defined asymmetric distribution (corresponding to synthetic compound 506). Tetraacyl lipid A (precursor IVa or synthetic 406), which lacks the two hydroxylated acyl chains, is agonistically completely inactive, but is a strong antagonist to bioactive LPS when administered to the cells before LPS addition. The two negative charges of lipid A, represented by the two phosphate groups, are essential for agonistic as well as for antagonistic activity and no highly active lipid A are known with negative charges other than phosphate groups. We hypothesized that the phosphate groups could be substituted by other negatively charged groups without changing the endotoxic properties of lipid A. To test this hypothesis, we synthesized carboxymethyl (CM) derivatives of hexaacyl lipid A (CM-506 and Bis-CM-506) and of tetraacyl lipid A (Bis-CM-406) and correlated their physicochemical with their endotoxic properties. We found that, similarly to compounds 506 and 406, also for their carboxymethyl derivatives a particular molecular ('endotoxic') conformation and with that, a particular aggregate structure is a prerequisite for high cytokine-inducing capacity and antagonistic activity, respectively. In other parameters such as acyl chain melting behaviour, antibody binding, activity in the Limulus lysate assay, and partially the binding of 3-deoxy-D-manno-oct-2-ulosonic acid transferase, strong deviations from the properties of the phosphorylated compounds were observed. These data allow a better understanding of endotoxic activity and its structural prerequisites. 相似文献
54.
Syntaxonomy and biogeography of dry grasslands on calcareous substrates in the central and southern Balkans
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Vlado Matevski Andraž Čarni Renata Ćušterevska Mitko Kostadinovski Ladislav Mucina 《应用植被学》2018,21(3):488-513
Questions
Which major syntaxa of dry grasslands supported by carbonate bedrock occur in the central and southern Balkans? What is their position along major ecological gradients and in the context of phytogeographic patterns of the region?Location
Central and southern Balkans, including western Bulgaria, northern Greece, Kosovo, Macedonia (FYROM) and Serbia.Methods
We compiled a matrix of 660 relevés of dry grasslands over lime‐rich bedrock, previously classified in the Festuco‐Brometea. We applied clustering techniques to classify separately synoptic and relevé data, and applied NMDS with passive projection of indicator values, climatic data and biogeographic geo‐elements onto ordination diagrams to assist interpretation of the syntaxonomic patterns. We constructed elevation distribution profiles for alliances and classes of grasslands of several grassland classes from a broader study area to elucidate the relationship of the elevational sorting of the syntaxa in relation to latitude.Results
The analysis revealed six major vegetation types, classified into four orders: (1) Stipo pulcherrimae‐Festucetalia pallentis, incl. (sub)montane rocky steppic grasslands of the Saturejion montanae of central Balkans, and the Koelerio‐Festucion dalmaticae – submontane rocky grasslands of southern Serbia and Kosovo; (2) Astragalo onobrychidis‐Potentilletalia represented by the Saturejo‐Thymion (low‐elevation steppic grasslands of southern Balkans); (3) Festucetalia valesiacae represented by grasslands on deep soil and low elevation of northern Greece, and finally (4) high‐elevation rocky grasslands of southern Balkans, classified as a new alliance – Diantho haematocalycis‐Festucion hirtovaginatae, that might belong to a new, yet undescribed, syntaxonomic order. Ordination suggests that the major differentiation of the high‐rank syntaxa follows north–south geographic and low–high elevation gradients.Conclusions
Because of the transitional biogeographic position of the studied region, as well as considerable large elevation span across latitudes, the diversity of vegetation types is high. The indication a putative new dry grassland order, the mid‐high altitudes of the southern Balkans points to a need to re‐assess the Balkan vegetation occupying the community niche between the low‐elevation dry grasslands (Festuco‐Brometea) and those typical of high elevations (Elyno‐Seslerietea and Daphno‐Festucetea), seeking parallels to patterns described from the western Alps, Pyrenees, and Apennines. This syntaxonomic unit is poised to expand the concept of the Festuco hystricis‐Ononidetea striatae to the Balkans.55.
Maria Sporbert Petr Keil Gunnar Seidler Helge Bruelheide Ute Jandt Svetlana Aćić Idoia Biurrun Juan Antonio Campos Andraž Čarni Milan Chytrý Renata Ćušterevska Jürgen Dengler Valentin Golub Florian Jansen Anna Kuzemko Jonathan Lenoir Corrado Marcenò Jesper Erenskjold Moeslund Aaron Pérez-Haase Solvita Rūsiņa Urban Šilc Ioannis Tsiripidris Vigdis Vandvik Kiril Vasilev Risto Virtanen Erik Welk 《Journal of Biogeography》2020,47(10):2210-2222
56.
The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle 总被引:1,自引:0,他引:1
Derewenda U Oleksy A Stevenson AS Korczynska J Dauter Z Somlyo AP Otlewski J Somlyo AV Derewenda ZS 《Structure (London, England : 1993)》2004,12(11):1955-1965
Calcium sensitization in smooth muscle is mediated by the RhoA GTPase, activated by hitherto unspecified nucleotide exchange factors (GEFs) acting downstream of Galphaq/Galpha(12/13) trimeric G proteins. Here, we show that at least one potential GEF, the PDZRhoGEF, is present in smooth muscle, and its isolated DH/PH fragment induces calcium sensitization in the absence of agonist-mediated signaling. In vitro, the fragment shows high selectivity for the RhoA GTPase. Full-length fragment is required for the nucleotide exchange, as the isolated DH domain enhances it only marginally. We crystallized the DH/PH fragment of PDZRhoGEF in complex with nonprenylated human RhoA and determined the structure at 2.5 A resolution. The refined molecular model reveals that the mutual disposition of the DH and PH domains is significantly different from other previously described complexes involving DH/PH tandems, and that the PH domain interacts with RhoA in a unique mode. The DH domain makes several specific interactions with RhoA residues not conserved among other Rho family members, suggesting the molecular basis for the observed specificity. 相似文献
57.
58.
Howe J Bauer J Andrä J Schromm AB Ernst M Rössle M Zähringer U Rademann J Brandenburg K 《The FEBS journal》2006,273(22):5101-5112
Synthetic rhamnolipids, derived from a natural diacylated glycolipid, RL-2,2(14), produced by Burkholderia (Pseudomonas) plantarii, were analyzed biophysically. Changes in the chemical structures comprised variations in the length, the stereochemistry and numbers of the lipid chains, numbers of rhamnoses, and the occurrence of charged or neutral groups. As relevant biophysical parameters, the gel (beta) to liquid crystalline (alpha) phase behavior of the acyl chains of the rhamnoses, their three-dimensional supramolecular aggregate structure, and the ability of the compounds to intercalate into phospholipid liposomes in the absence and presence of lipopolysaccharide-binding protein were monitored. Their biological activities were examined as the ability to induce cytokines in human mononuclear cells and to induce chemiluminescence in monocytes. Depending on the particular chemical structures, the physicochemical parameters as well as the biological test systems show large variations. This relates to the acyl chain fluidity, aggregate structure, and intercalation ability, as well as the bioactivity. Most importantly, the data extend our conformational concept of endotoxicity, based on the intercalation of naturally originating amphiphilic virulence factors into membranes from immune cells. This 'endotoxin conformation', produced by amphiphilic molecules with a hydrophilic charged backbone and apolar hydrophobic moiety, and adopting inverted cubic aggregate structures, causes high mechanical stress in target immune cells on integral proteins, eventually leading to cell activation. Furthermore, biologically inactive rhamnolipids with lamellar aggregate structures antagonize the endotoxin-induced activity in a way similar to lipid A-derived antagonists. 相似文献
59.
Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia 总被引:3,自引:0,他引:3
Microglial cells, the resident macrophages of the CNS, can be both beneficial and detrimental to the brain. These cells play a central role as mediators of neuroinflammation associated with many neurodegenerative states, including cerebral ischemia. Because microglial cells are both a major source of inducible nitric oxide synthase (iNOS)/nitric oxide (NO) production locally in the injured brain and are activated by NO-mediated injury, we tested whether iNOS inhibition reduces microglial activation and ischemic injury in a neonatal focal ischemia-reperfusion model. Post-natal day 7 rats were subjected to a 2 h transient middle cerebral artery (MCA) occlusion. Pups with confirmed injury on diffusion-weighted magnetic resonance imaging (MRI) during occlusion were administered 300 mg/kg/dose aminoguanidine (AG) or vehicle at 0, 4 and 18 h after reperfusion, and animals were killed at 24 or 72 h post-reperfusion. The effect of AG on microglial activation as judged by the acquisition of ED1 immunoreactivity and proliferation of ED1-positive cells, on activation of cell death pathways and on injury volume, was determined. The study shows that while AG attenuates caspase 3 and calpain activation in the injured tissue, treatment does not affect the rapidly occurring activation and proliferation of microglia following transient MCA occlusion in the immature rat, or reduce injury size. 相似文献
60.
Ibrahim Cakmak Daniel S. Song T. Andrew Mixson Eduardo Serrano Meredith L. Clement Amy Savitski Ge’Andra Johnson Tugrul Giray Charles I. Abramson John F. Barthell Harrington Wells 《Journal of Insect Behavior》2010,23(2):100-116
Foraging behavior of Apis mellifera caucasica, A.m. carnica and A.m. syriaca in Turkey was studied for intrinsic subspecies-based differences. Models of forager flower-color fidelity, risk sensitive behavior and maximizing net gain were tested. Foragers were presented artificial flower patches containing blue, white and yellow flowers. Some bees of each subspecies showed high fidelity to yellow flowers, while others favored blue and white flowers. The degree of fidelity, however, differed among subspecies and was dependent upon which color was favored. Bees of all subspecies demonstrated risk indifferent behavior regardless of whether they favored yellow flowers or blue and white flowers. Flower handling time differed among subspecies and increased with reward quantity, and when a reward was present. Flight time between consecutive flowers also differed among honey bee subspecies. Foragers of all subspecies had a higher net gain when visiting flowers with consistent rewards. 相似文献