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71.
72.
Benjamin Tycko L. Feng L. Nguyen Aren Francis Allison Hays Wai-Yee Chung Ming-Xin Tang Yaakov Stern Amrik Sahota Hugh Hendrie R. Mayeux 《Human genetics》1996,98(4):430-436
Apolipoprotein-J/clusterin (APOJ/CLI) shares many biological properties with apolipoprotein-Ε (APOE) including, but not limited to, avid binding with β-amyloid peptide. Thus, APOJ/CLI warrants scrutiny as a candidate Alzheimer’s disease (AD) susceptibility gene. We identified seven nucleotide sequence polymorphisms
in APOJ/ CLI, two of which, in exon 7, alter the predicted amino acid sequence. The JVIIB variant is an asparagine-to-histidine substitution,
which deletes a glycosylation signal at amino acid 317; the JVIIC variant is an aspartate-to-asparagine substitution, which
forms a new glycosylation signal at position 328. Both of these coding variants, as well as two neutral polymorphisms in exon
2, were more frequent in African-Americans than Hispanics and were rare in Caucasians. However, no individual coding or noncoding
variant was consistently associated with AD. At the population level, APOJ/CLI polymorphisms are frequent among persons of African descent, but probably do not alter susceptibility to AD.
Received: 14 February 1996 / Revised: 15 April 1996 相似文献
73.
Amrik Bhattacharya 《Bioremediation Journal》2017,21(3-4):109-118
This study aimed to evaluate the efficiency of Burkholderia xenovorans LB400 cells and their cell extract to remediate 4-chlorobiphenyl (4-CB). The bacterium previously induced with 4-CB was able to degrade up to 98% of initial 50 mg L?1 of 4-CB from mineral medium within 96 h of incubation. The degradation of 4-CB occurred through the formation of meta-cleavage product 2-hydroxy-6-oxo-6phenylhexa-2,4-dienoic acid (HOPDA), as revealed through enzymatic assay of 2,3-dihydroxybiphenyl 1,2-dioxygenase (2,3-DHBD). A derivative of 1,2-benzenedicarboxylic acid was observed as one of the major intermediate metabolites of 4-CB degradation. Time course production of 2,3-DHBD during growth corresponds with the degradation pattern of 4-CB by the bacterium. In vitro degradation of 4-CB using cell extract of B. xenovorans showed complete degradation of initial 25 mg L?1 of 4-CB within 6 h of incubation. To the best of the authors' knowledge, this is the first report in which in vitro degradation of 4-CB using cell extract of Burkholderia xenovorans is presented. 相似文献
74.
F G Peet T S Sahota 《Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology》1988,10(3):171-175
The absorbance values of a cell nucleus, as measured at each pixel location, can be considered as forming a surface in a three-dimensional space. The principal curvatures of differential geometry can then be evaluated for this surface. From these curvatures, two new variables are computed that, when averaged over all pixels in the nucleus, are viewed as image texture measures. These two measures were found to be effective for differentiating insect populations and compared well with other features used in the TICAS system. This paper presents the results of comparing the performance of these two features with the performance of other features for several populations of cells. 相似文献
75.
An approach to the statistical testing of differences between two cell populations the elements of which are characterized by multivariate data is described. The approach is based on the Fisher discriminant and the Kruskal-Wallis test. The method, which is sufficient but not necessary, makes no assumptions about the normality of the data or about the equality of the covariance matrices for each population. 相似文献