全文获取类型
收费全文 | 4311篇 |
免费 | 281篇 |
国内免费 | 3篇 |
出版年
2023年 | 26篇 |
2022年 | 65篇 |
2021年 | 152篇 |
2020年 | 58篇 |
2019年 | 74篇 |
2018年 | 119篇 |
2017年 | 90篇 |
2016年 | 157篇 |
2015年 | 185篇 |
2014年 | 248篇 |
2013年 | 302篇 |
2012年 | 342篇 |
2011年 | 369篇 |
2010年 | 213篇 |
2009年 | 199篇 |
2008年 | 234篇 |
2007年 | 207篇 |
2006年 | 201篇 |
2005年 | 153篇 |
2004年 | 151篇 |
2003年 | 105篇 |
2002年 | 100篇 |
2001年 | 70篇 |
2000年 | 57篇 |
1999年 | 50篇 |
1998年 | 20篇 |
1997年 | 22篇 |
1995年 | 23篇 |
1994年 | 18篇 |
1993年 | 19篇 |
1992年 | 30篇 |
1991年 | 15篇 |
1990年 | 34篇 |
1989年 | 19篇 |
1988年 | 30篇 |
1987年 | 26篇 |
1986年 | 33篇 |
1985年 | 27篇 |
1984年 | 20篇 |
1983年 | 23篇 |
1982年 | 21篇 |
1981年 | 26篇 |
1979年 | 28篇 |
1978年 | 18篇 |
1977年 | 15篇 |
1975年 | 20篇 |
1974年 | 18篇 |
1973年 | 19篇 |
1972年 | 22篇 |
1970年 | 17篇 |
排序方式: 共有4595条查询结果,搜索用时 15 毫秒
71.
The growth hormone (GH) receptor belongs to a novel receptor family which shares significant amino-acid sequence homology and includes prolactin receptors, erythropoietin receptors and several cytokines' receptors. GH and three other members of this family of receptors have been shown to have circulating soluble forms. The present review summarizes our knowledge on receptor related binding proteins, discusses their possible biological effects and suggests their use in novel assays for their ligands. The GH-binding protein (GH-BP) was the first to have been described and is used as a model for the concept. A series of indirect pieces of evidence suggest that the measurement of circulating GH-BP may enable an evaluation of the GH-receptor. When covalently bound to GH, GH-BP has been shown to slow the clearance of GH. On the other hand GH-BP competes with the GH-receptor for GH binding and, thus, diminishes the biological effect of GH. We suggest a biological role for GH-BP as follows: an increase in the availability of GH results not only in the upregulation of the GH-receptor but also in increased turnover of this receptor, its internalization and recycling. This is followed by a concomitant increase in GH-BP which, in turn, mitigates the effect of GH by competing with the receptor on GH binding. The extracellular domain of the GH-receptor is homologous, to a large extent, with the sequence of several receptors for hormones and cytokines, which have recently been cloned.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
72.
G Mukherjee D Banerjee D K Bhattacharya G C Chatterjee 《Indian journal of experimental biology》1990,28(6):550-552
Collagen stimulation of blood platelets resulted in significant increases in malondialdehyde (MDA) formation and activity of glucose-6-phosphate dehydrogenase (G6PDH) and a decrease in catalase and glutathione peroxidase (GPx). Retinoic acid (RA) pretreatment did not show any appreciable changes except for a decrease in G6PDH activity as compared with collagen alone. RA pretreatment of human blood platelets resulted in an increase in the activities of catalase and GPx, two important radical scavenging enzymes, with significant decrease in MDA formation when compared with ADP alone. It is suggested that RA has a significant effect on the antioxidant defence system in ADP stimulated platelets but not in the collagen stimulated platelets. 相似文献
73.
Differential effect of retinoic acid on ADP and collagen induced platelet aggregation 总被引:3,自引:0,他引:3
G Mukherjee G C Chatterjee D Banerjee D K Bhattacharya 《Indian journal of experimental biology》1990,28(10):949-952
Retinoic acid (RA) was found to inhibit ADP induced but not collagen induced aggregation of human platelets and the differential action is related to intraplatelet Ca2+ reflux. RA was active at concentrations as low as 10(-7) M and required 20 min prior incubation with platelet suspension in order to inhibit aggregation by ADP. All the steps in ADP induced but not collagen induced platelet activation, viz. hydrolysis of phosphatidyl inositol, phosphorylation of 20, 47 and 250 kDa proteins as well as increased association of actin with Triton X-100 insoluble cytoskeletal matrix were inhibited by RA. RA when used as an agent for differentiation induction of cell progenitor is likely to affect the platelet aggregation and thereby the haemostatic process. 相似文献
74.
75.
76.
Seedlings of Vigna catjang Endl. were subjected to water stress for 6, S and 10 days by withholding water to investigate the activities of some oxidative enzymes and the pattern of senescence in leaves of 17-day-old seedlings undergoing water stress. Increasing duration of stress produced a proportional increase in the activities of IAA-oxidase, AA-oxidase, peroxidase and glycolate oxidase but decreased catalase activity and the contents of both chlorophyll and protein, hastening senescence. Leaf water potential and relative water content were also lowered with incresing duration of stress. Permeability was increased in leaf tissue undergoing water stress for 8 days. Seed treatment with CaCl2 (10−2 and 10−14 M ) for 6 h improved the water status of leaves, decreased tissue permeability, activities of oxidative enzymes, decline of chlorophyll and protein contents and delayed senescence compared to untreated water stressed plants. 相似文献
77.
Cystinotic and normal fibroblasts: Differential susceptibility to cysteine toxicity in vitro 总被引:2,自引:0,他引:2
Sheldon Orloff Anil B. Mukherjee Jean DeB Butler Barbara Foley Joseph D. Schulman 《In vitro cellular & developmental biology. Plant》1980,16(8):655-660
Summary Extracellular cysteine concentrations between 0.5 and 2.5 mM resulted in death of normal but not cystinotic cells grown in Eagle's minimal essential medium containing supplemental fetal
bovine serum and antibiotics. Differential cell survival was determined by viable cell counting using Trypan Blue dye exclusion.
In cocultivation experiments of [3H]thymidine-labelled cystinotic fibroblasts with nonradioactive normal fibroblasts, autoradiography confirmed the selective
survival of cystinotic cells in medium containing 1 mM cysteine. At this concentration of 1 mM cysteine, intracellular cystine content increased slightly in surviving normal cells but not in cystinotic cells, which normally
contain a high level of intracellular cystine. This comparative resistance of cystinotic fibroblasts to elevated extracellular
cysteine concentrations forms the basis for an in vitro selective system for these mutant human cells. Further exploration
of this resistance phenomenon may well expand the understanding of the molecular defect in cystinotic cells. 相似文献
78.
On a new charophyte from India 总被引:1,自引:1,他引:0
Chara indica is described as a new species on morphological and cytological grounds.Part of Ph. D. Thesis of Ranchi University. 相似文献
79.
Dehydroascorbic acid reduction in human erythrocytes 总被引:1,自引:0,他引:1
S Basu S Som S Deb D Mukherjee I B Chatterjee 《Biochemical and biophysical research communications》1979,90(4):1335-1340
80.
Asish K. Sen Amal K. Mukherjee Bhakti Guhathakurta Archana Dutta Dipti Sasmal 《Carbohydrate research》1979
On hydrolysis, the purified lipopolysaccharide (LPS) isolated from Vibrio cholera, Inaba 569 B, yielded glucose, mannose, a heptose behaving like d-glycero-l-manno-heptose and one behaving like d-glycero-l-gluco-heptose, 2-amino-2-deoxy-glucose, and glucuronic acid in the molar ratios of ~9:4:5:1:2:5. Studies on the LPS, the polysaccharide (PS), and carboxyl-reduced LPS showed that the PS has a branched structure, with (1→2)-linked mannopyranosyl and a heptopyranosyl, and (1→4)-linked glucopyranosyluronic and 2-amino-2-deoxyglucopyranosyl residues in the interior part of the molecule, and glucopyranosyl and heptopyranosyl residues as nonreducing end-groups. 相似文献