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991.
Shirin Soleimani Milad Shamsi Mehran Akbarpour Ghazani Hassan Pezeshgi Modarres Karolina Papera Valente Mohsen Saghafian Mehdi Mohammadi Ashani Mohsen Akbari Amir Sanati-Nezhad 《Biotechnology advances》2018,36(4):880-893
Emerging evidence shows that endothelial cells are not only the building blocks of vascular networks that enable oxygen and nutrient delivery throughout a tissue but also serve as a rich resource of angiocrine factors. Endothelial cells play key roles in determining cancer progression and response to anti-cancer drugs. Furthermore, the endothelium-specific deposition of extracellular matrix is a key modulator of the availability of angiocrine factors to both stromal and cancer cells. Considering tumor vascular network as a decisive factor in cancer pathogenesis and treatment response, these networks need to be an inseparable component of cancer models. Both computational and in vitro experimental models have been extensively developed to model tumor-endothelium interactions. While informative, they have been developed in different communities and do not yet represent a comprehensive platform. In this review, we overview the necessity of incorporating vascular networks for both in vitro and in silico cancer models and discuss recent progresses and challenges of in vitro experimental microfluidic cancer vasculature-on-chip systems and their in silico counterparts. We further highlight how these two approaches can merge together with the aim of presenting a predictive combinatorial platform for studying cancer pathogenesis and testing the efficacy of single or multi-drug therapeutics for cancer treatment. 相似文献
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Amir Yassin 《法国昆虫学会纪事》2018,54(2):167-175
The Drosophila montium group is the largest clade of the subgenus Sophophora consisting of 94 palaeotropical species, whose phylogenetic relationships remain unclear. Here, I used a recent tree inferred from three nuclear genes and one mitochondrial gene for almost half of the species to reconstruct the historical biogeography of the group and propose a comprehensive classification for the totality of its species. The group originated in South-East Asia nearly 20 million years ago (mya), and dispersed to Africa in the Late Miocene. A second northward expansion into East Asia took place in the Pliocene. Based on morphological (male abdominal pigmentation and genitalia) and chorological traits congruent with the molecular tree, I divide the montium group into seven subgroups: parvula, montium, punjabiensis, serrata, kikkawai, seguyi and orosa. The polyphyletic status of some of the previously defined complexes (auraria, jambulina, serrata, kikkawai and nikananu) is also resolved. 相似文献
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Targeting the tumor microenvironment as a potential therapeutic approach in colorectal cancer: Rational and progress 下载免费PDF全文
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MSCs ameliorates DPN induced cellular pathology via [Ca2+]i homeostasis and scavenging the pro‐inflammatory cytokines 下载免费PDF全文
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Current status and future prospective of Curcumin as a potential therapeutic agent in the treatment of colorectal cancer 下载免费PDF全文
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