全文获取类型
收费全文 | 177篇 |
免费 | 9篇 |
国内免费 | 1篇 |
出版年
2022年 | 4篇 |
2021年 | 2篇 |
2016年 | 4篇 |
2015年 | 5篇 |
2014年 | 4篇 |
2013年 | 7篇 |
2012年 | 14篇 |
2011年 | 16篇 |
2010年 | 5篇 |
2009年 | 4篇 |
2008年 | 3篇 |
2007年 | 7篇 |
2006年 | 2篇 |
2005年 | 4篇 |
2004年 | 5篇 |
2003年 | 10篇 |
2002年 | 10篇 |
2001年 | 4篇 |
2000年 | 7篇 |
1999年 | 2篇 |
1994年 | 1篇 |
1992年 | 2篇 |
1990年 | 3篇 |
1988年 | 3篇 |
1984年 | 1篇 |
1982年 | 2篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1972年 | 1篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1963年 | 9篇 |
1962年 | 10篇 |
1961年 | 3篇 |
1959年 | 1篇 |
1958年 | 2篇 |
1956年 | 2篇 |
1955年 | 1篇 |
1951年 | 3篇 |
1950年 | 1篇 |
1944年 | 1篇 |
1943年 | 2篇 |
1942年 | 1篇 |
1941年 | 1篇 |
1940年 | 3篇 |
1937年 | 1篇 |
1936年 | 2篇 |
1935年 | 2篇 |
1932年 | 2篇 |
排序方式: 共有187条查询结果,搜索用时 31 毫秒
1.
NEW MURID RODENTS FROM THE LATE CENOZOIC OF YUSHE BASIN, SHANXI 总被引:8,自引:8,他引:0
Lawrence J.Flynn 《古脊椎动物学报》1992,(1)
<正> As scientific collaborators of the Chinese-American joint project "Neogene Rocks and Faunas, Yushe Basin, Shanxi, PRC", the present authors, with William R. Downs, Northern Arizona University, sampled the Yushe microfauna in the fall of 1987 and 1988. The fossil temains were retrieved by surface collection and by wet-sieving bulk quantities of sediment. 相似文献
2.
3.
I Feinkohl N Sattar P Welsh RM Reynolds IJ Deary MW Strachan JF Price;on behalf of the Edinburgh Type Diabetes Study 《PloS one》2012,7(9):e44569
Background
Type 2 diabetes mellitus is associated with risk of congestive heart failure (CHF), cognitive dysfunction and depression. CHF itself is linked both to poor cognition and depression. The ventricular N-terminal pro-brain natriuretic peptide (NT-proBNP) is a marker of CHF, suggesting potential as a marker for cognitive impairment and/or depression. This was tested in the Edinburgh Type 2 Diabetes Study (ET2DS).Methodology and Principal Findings
Cross-sectional analysis of 1066 men and women aged 60–75 with type 2 diabetes. Results from seven neuropsychological tests were combined in a standardised general cognitive ability factor, ‘g’. A vocabulary-based test estimated pre-morbid cognitive ability. The Hospital Anxiety and Depression Scale (HADS) assessed possible depression. After adjustment for age and sex, raised plasma NT-proBNP was weakly associated with lower ‘g’ and higher depression scores (ß −0.09, 95% CI −0.13 to −0.03, p = 0.004 and ß 0.08, 95% CI 0.04 to 0.12, p<0.001, respectively). Comparing extreme quintiles of NT-proBNP, subjects in the highest quintile were more likely to have reduced cognitive ability (within the lowest tertile of ‘g’) and ‘possible’ depression (HADS depression ≥8) (OR 1.80; 95% CI: 1.20, 2.70; p = 0.005 and OR 2.18; 95% CI: 1.28, 3.71; p = 0.004, respectively). Associations persisted when pre-morbid ability was adjusted for, but as expected were no longer statistically significant following the adjustment for diabetes-related and vascular co-variates (β −0.02, 95% CI −0.07 to 0.03, p>0.05 for ‘g’; β 0.03, 95% CI −0.02 to 0.07, p>0.05 for depression scores).Conclusion
Raised plasma NT-proBNP was weakly but statistically significantly associated with poorer cognitive function and depression. The prospective phases of the ET2DS will help determine whether or not NT-proBNP can be considered a risk marker for subsequent cognitive impairment and incident depression and whether it provides additional information over and above traditional risk factors for these conditions. 相似文献4.
5.
6.
7.
8.
9.
Ole?A. Andreassen Srdjan Djurovic Wesley?K. Thompson Andrew?J. Schork Kenneth?S. Kendler Michael?C. O’Donovan Dan Rujescu Thomas Werge Martijn van?de?Bunt Andrew?P. Morris Mark?I. McCarthy International Consortium for Blood Pressure GWAS Diabetes Genetics Replication Meta-analysis Consortium Psychiatric Genomics Consortium Schizophrenia Working Group J.?Cooper Roddey Linda?K. McEvoy Rahul?S. Desikan Anders?M. Dale 《American journal of human genetics》2013,92(2):197-209
Several lines of evidence suggest that genome-wide association studies (GWASs) have the potential to explain more of the “missing heritability” of common complex phenotypes. However, reliable methods for identifying a larger proportion of SNPs are currently lacking. Here, we present a genetic-pleiotropy-informed method for improving gene discovery with the use of GWAS summary-statistics data. We applied this methodology to identify additional loci associated with schizophrenia (SCZ), a highly heritable disorder with significant missing heritability. Epidemiological and clinical studies suggest comorbidity between SCZ and cardiovascular-disease (CVD) risk factors, including systolic blood pressure, triglycerides, low- and high-density lipoprotein, body mass index, waist-to-hip ratio, and type 2 diabetes. Using stratified quantile-quantile plots, we show enrichment of SNPs associated with SCZ as a function of the association with several CVD risk factors and a corresponding reduction in false discovery rate (FDR). We validate this “pleiotropic enrichment” by demonstrating increased replication rate across independent SCZ substudies. Applying the stratified FDR method, we identified 25 loci associated with SCZ at a conditional FDR level of 0.01. Of these, ten loci are associated with both SCZ and CVD risk factors, mainly triglycerides and low- and high-density lipoproteins but also waist-to-hip ratio, systolic blood pressure, and body mass index. Together, these findings suggest the feasibility of using genetic-pleiotropy-informed methods for improving gene discovery in SCZ and identifying potential mechanistic relationships with various CVD risk factors. 相似文献
10.
Yoshiko Onda Rimei Nishimura Aya Morimoto Hironari Sano Kazunori Utsunomiya Naoko Tajima The Diabetes Epidemiology Research International Mortality Study Group 《PloS one》2016,11(3)