Japanese guideline for the management of hyperuricemia and gout: second edition

Gout is a urate deposition disease caused by persistent hyperuricemia. Because gout patients present with a variety of clinical symptoms, it is necessary to have a guideline for the standard management and care of gout and hyperuricemia. The Japanese Society of Gout and Nucleic Acid Metabolism, a scientific society committed to study nucleic acid metabolism and related diseases, established the first edition of the "Guideline for the Management of Hyperuricemia and Gout" in 2002, and published the revised version in January 2010. This second edition is not only evidence based on a search of systemic literature, but also includes consensus levels by a Delphi exercise to determine the strength of the recommendations. A draft version of this guideline was reviewed by internal and external reviewers as well as a patient. In this guideline, key messages from each chapter are listed as statements together with the evidence level, consensus level, and strength of the recommendation. In this proceeding, several selected chapters on the clinical management of gout and hyperuricemia are described. We hope this guideline is appropriately used for the standard management and care of patients with hyperuricemia and gout in daily practice.     

交联对胶原降解速率的影响

目的：研究交联反应对胶原降解速率的影响。方法：以热交联(DHT)、1-乙基-3-(3-二甲基氨丙基)-碳化二亚胺(EDC)化学交联以及EDC／DHT交联三种方法对胶原海绵材料进行处理,并测定材料在处理前后的降解速率。结果：各种交联反应均不同程度地提高了胶原的生物稳定性．降低了胶原的降解速率。     

天然抗氧化剂对ONOO~-损伤的抑制效应

过氧亚硝基阴离子(ONOO-)是生物体内产生的一种强氧化剂和细胞毒性物质。它可以介导生物大分子(包括DNA、蛋白质和脂质)的修饰与损伤。本文着重介绍四类主要的天然抗氧化剂——生物碱、多酚、多糖以及萜类抗氧化剂及其抑制ONOO-损伤的研究进展,并对未来的研究作了展望。     

Conceptual comparison of metabolic pathways with electronic circuits

1 Introduction Based on the review of the previous work on genecircuits [1–7] , this paper discusses an electronic circuitwhich has been designed to mimic glycolysis, the CitricAcid (TCA) cycle and the electron transport chain. En-zymes play a vital role in metabolic pathways. Thespecificity of enzymic action is explained in terms of theprecise fitting of enzyme and substrate [8–9] . Enzymes areusually very specific…