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991.
Yelan Wang Danni Sun Zongwei Yue Weiting Tang Bo Xiao Li Feng 《Neurochemical research》2016,41(9):2215-2222
Malformations of cortical development (MCD) are critical brain development disorders associated with varied abnormalities in both anatomic structures and neural functioning. It is also a very common etiology to the epilepsy, in which the alteration on excitability of cortical neurons is hypothesized as one of important causes to the epileptic seizures. Due to the key role in regulating neuron firing properties, the plasticity of axon initial segment (AIS) was investigated in present study to further determine the relation between MCD and epilepsy. Our results showed a prolonged decrease in the length of AIS occurred in MCD animal models. Besides, the AIS was also found greatly shortened in MCD models during the acute, but not chronic phase of status epileptics compared with intact controls. Our findings of identification of AIS plasticity in MCD animal models and its hypersensitivity to status epilepsy are significant in furthering our understanding of the pathophysiological mechanisms involved in this disorder. 相似文献
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Zdenka Gasparova Nada Pronayova Veronika Stara Tibor Liptaj 《Neurochemical research》2016,41(4):715-721
Search for indicators of neurodegenerative disorders is a hot topic where much research remains to be done. Our aim was to determine proton nuclear magnetic resonance (1H-NMR) spectra of brain metabolites in the trimethyltin (TMT) model of neurodegeneration. Male Wistar rats were subjected to TMT or saline and were sacrificed on day 3 or 24 after administration. 1H-NMR spectrum was measured on the 600 MHz Varian VNMRS spectrometer in nano-probe in the volume of 40 μl of hippocampal extracts. TMT administration resulted in reduction of the hippocampal weight on day 24. Of the sixteen identified metabolite spectra, decreased aspartate and increased glutamine contents were observed in the initial asymptomatic stage of neurodegeneration on day 3 in hippocampal extracts of TMT exposed rats compared to sham animals. Increased myo-inositol content was observed on day 24. The presented data provide further knowledge about this experimental model and putative indicators of neuronal damage. 相似文献
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John A. Hribljan Esteban Suárez Katherine A. Heckman Erik A. Lilleskov Rodney A. Chimner 《Wetlands Ecology and Management》2016,24(2):113-127
The páramo is a high altitude tropical Andean ecosystem that contains peatlands with thick horizons of carbon (C) dense soils. Soil C data are sparse for most of the páramo, especially in peatlands, which limits our ability to provide accurate regional and country wide estimates of C storage. Therefore, the objective of our research was to quantify belowground C stocks and accumulation rates in páramo peatland soils in two regions of northeastern Ecuador. Peatland soil cores were collected from Antisana Ecological Reserve and Cayambe-Coca National Park. We measured soil C densities and 14C dates to estimate soil accumulation rates. The mean peatland soil depth across both regions was 3.8 m and contained an estimated mean C storage of 1282 Mg ha?1. Peatlands older than 3000 cal. year BP had a mean long-term C accumulation rate of 26 g m?2 year?1, with peatlands younger than 500 cal. year BP displaying mean recent rates of C accumulation of 134 g m?2 year?1. These peatlands also receive large inputs of mineral material, predominantly from volcanic deposition, that has created many interbedded non-peat mineral soil horizons that contained 48 % of the soil C. Because of large C stocks in Ecuadorian mountain peatlands and the potential disturbance from land use and climate change, additional studies are need to provide essential baseline assessments and estimates of C storage in the Andes. 相似文献
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In the present study, the capacity of enrichments derived from marine sediments collected from different sites of the Mexican littoral to perform anaerobic ammonium oxidation (anammox) coupled to sulfide-dependent denitrification for simultaneous removal of ammonium and sulfide linked to nitrite reduction was evaluated. Sulfide-dependent denitrification out-competed anammox during the simultaneous oxidation of sulfide and ammonium. Significant accumulation of elemental sulfur (ca. 14–30 % of added sulfide) occurred during the coupling between the two respiratory processes, while ammonium was partly oxidized (31–47 %) due to nitrite limitation imposed in sediment incubations. Nevertheless, mass balances revealed up to 38 % more oxidation of the electron donors available (ammonium and sulfide) than that expected from stoichiometry. Recycling of nitrite, from nitrate produced through anammox, is proposed to contribute to extra oxidation of sulfide, while additional ammonium oxidation is suggested by sulfate-reducing anammox (SR-anammox). The complex interaction between nitrogenous and sulfurous compounds occurring through the concomitant presence of autotrophic denitrification, conventional anammox and SR-anammox may significantly drive the nitrogen and sulfur fluxes in marine environments. 相似文献
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