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排序方式: 共有595条查询结果,搜索用时 15 毫秒
591.
Xin Sun Claudia Frey Emilio Garcia-Robledo Amal Jayakumar Bess B. Ward 《The ISME journal》2021,15(5):1317
Nitrite is a pivotal component of the marine nitrogen cycle. The fate of nitrite determines the loss or retention of fixed nitrogen, an essential nutrient for all organisms. Loss occurs via anaerobic nitrite reduction to gases during denitrification and anammox, while retention occurs via nitrite oxidation to nitrate. Nitrite oxidation is usually represented in biogeochemical models by one kinetic parameter and one oxygen threshold, below which nitrite oxidation is set to zero. Here we find that the responses of nitrite oxidation to nitrite and oxygen concentrations vary along a redox gradient in a Pacific Ocean oxygen minimum zone, indicating niche differentiation of nitrite-oxidizing assemblages. Notably, we observe the full inhibition of nitrite oxidation by oxygen addition and nitrite oxidation coupled with nitrogen loss in the absence of oxygen consumption in samples collected from anoxic waters. Nitrite-oxidizing bacteria, including novel clades with high relative abundance in anoxic depths, were also detected in the same samples. Mechanisms corresponding to niche differentiation of nitrite-oxidizing bacteria across the redox gradient are considered. Implementing these mechanisms in biogeochemical models has a significant effect on the estimated fixed nitrogen budget.Subject terms: Biogeochemistry, Water microbiology, Microbial ecology 相似文献
592.
A. R. Zulkafli M. N. A. Amal S. Shohaimi A. Mustafa A. H. Ghani S. Hashim M. I. Anuar S. Ayub 《Zeitschrift fur angewandte Ichthyologie》2016,32(1):167-168
This study reports the length–weight relationships (LWR) of 15 fish species from Tembeling River, Pahang, Malaysia. The river flows adjacent to the National Park, Pahang, and supplies fishes for local consumption. In addition, this river also functions as a main water body for protection and breeding of commercial fish species. A total of eight LWRs were unknown to FishBase, and five new maximum lengths were identified from the study. 相似文献
593.
Mir Hilal Ahmad Balaram Ghosh Moshahid Alam Rizvi Mansoor Ali Loveleena Kaur Amal Chandra Mondal 《Journal of cellular physiology》2023,238(2):306-328
Neuroblastoma (NB) is one of the most common heterogeneous extracranial cancers in infancy that arises from neural crest (NC) cells of the sympathetic nervous system. The Wnt signaling pathway, both canonical and noncanonical pathway, is a highly conserved signaling pathway that regulates the development and differentiation of the NC cells during embryogenesis. Reports suggest that aberrant activation of Wnt ligands/receptors in Wnt signaling pathways promote progression and relapse of NB. Wnt signaling pathways regulate NC induction and migration in a similar manner; it regulates proliferation and metastasis of NB. Inhibiting the Wnt signaling pathway or its ligands/receptors induces apoptosis and abrogates proliferation and tumorigenicity in all major types of NB cells. Here, we comprehensively discuss the Wnt signaling pathway and its mechanisms in regulating the development of NC and NB pathogenesis. This review highlights the implications of aberrant Wnt signaling in the context of etiology, progression, and relapse of NB. We have also described emerging strategies for Wnt-based therapies against the progression of NB that will provide new insights into the development of Wnt-based therapeutic strategies for NB. 相似文献
594.
Wagdy M. Eldehna Mahmoud F. Abo-Ashour Tarfah Al-Warhi Sara T. Al-Rashood Amal Alharbi Rezk R. Ayyad Khayal Al-Khayal Maha Abdulla Hatem A. Abdel-Aziz Rehan Ahmad Radwan El-Haggar 《Journal of enzyme inhibition and medicinal chemistry》2021,36(1):319
Mitochondrial anti-apoptotic Bcl2 and BclxL proteins, are overexpressed in multiple tumour types, and has been involved in the progression and survival of malignant cells. Therefore, inhibition of such proteins has become a validated and attractive target for anticancer drug discovery. In this manner, the present studies developed a series of novel isatin–indole conjugates (7a-j and 9a-e) as potential anticancer Bcl2 and BclxL inhibitors. The progression of the two examined colorectal cancer cell lines was significantly inhibited by all of the prepared compounds with IC50 ranges132–611 nM compared to IC50 = 4.6 µM for 5FU, against HT-29 and IC50 ranges 37–468 nM compared to IC50 = 1.5 µM for 5FU, against SW-620. Thereafter, compounds 7c and 7g were selected for further investigations. Interestingly, both compounds exhibited selective cytotoxicity against both cell lines with high safety to normal fibroblast (HFF-1). In addition, both compounds 7c and 7g induced apoptosis and inhibited Bcl2 and BclxL expression in a dose-dependent manner. Collectively, the high potency and selective cytotoxicity suggested that conjugates 7c and 7g could be a starting point for further optimisation to develop novel pro-apoptotic and antitumor agents towards colon cancer. 相似文献
595.