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41.
Localization of human mononuclear cell interleukin 1 总被引:12,自引:0,他引:12
P J Conlon K H Grabstein A Alpert K S Prickett T P Hopp S Gillis 《Journal of immunology (Baltimore, Md. : 1950)》1987,139(1):98-102
The detection and localization of interleukin (IL) 1 in human monocytes was carried out by flow cytometry using monoclonal antibodies to IL-1 alpha and IL-1 beta proteins. IL-1 alpha was detected on the surface of monocytes and the surface expression increased following lipopolysaccharide activation. No demonstrable IL-1 beta protein could be observed on the cell surface by antibody staining, while both IL-1 alpha and IL-1 beta could be visualized intracellularly by the appropriate monoclonal antibodies following acetone permeabilization of the monocytes. Further experiments with cell associated IL-1 revealed that most of the biological activity of human monocytes could be inhibited by affinity purified polyclonal antibodies to IL-1 alpha protein, whereas no inhibitory activity was observed with IL-1 beta specific antibodies. These data support the hypothesis that a differential localization of IL-1 alpha and IL-1 beta exists within human blood-derived monocytes. 相似文献
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Ahmed Haouz Charles Twist Christian Zentz Patrick Tauc B. Alpert 《European biophysics journal : EBJ》1998,27(1):19-25
The catalytic oxidation of β-D-glucose by the enzyme glucose oxidase involves a redox change of the flavin coenzyme. The structure and the dynamics of
the two extreme glucose oxidase forms were studied by using infrared absorption spectroscopy of the amide I′ band, tryptophan
fluorescence quenching and hydrogen isotopic exchange. The conversion of FAD to FADH2 does not change the amount of α-helix present in the protein outer shell, but reorganises a fraction of random coil to β-sheet structure. The dynamics of the protein interior vary with the redox states of the flavin without affecting the motions
of the structural elements near the protein surface. From the structure of glucose oxidase given by X-ray crystallography,
these results suggest that the dynamics of the interface between the two monomers are involved in the catalytic mechanism.
Received: 27 December 1996 / Accepted: 18 July 1997 相似文献
44.
Unusual growth pattern in the Frasnian alveolitids (Tabulata) from the Holy Cross Mountains (Poland)
Abstract: Growth periodicity is a phenomenon occurring in fossil and modern corals. The most apparent feature is growth banding, and environmental changes are broadly accepted as controls on this phenomenon. If environment controls the growth, then all corallites within a colony should repeat the same growth pattern, as individuals are clones and must have shared the same environment. A study on several species of Alveolitidae (Anthozoa, Tabulata) from the Late Devonian (Early Frasnian) of the Holy Cross Mountains (Poland) shows that the growth pattern varies between neighbouring individuals within the same corallum. This contradicts observations of closely related Favositida as demonstrated on Pachyfavosites sp. from the Givetian of Avesnois, France, where neighbouring individuals repeat the same pattern. Therefore, environmental control on growth rhythm in Alveolitidae can be excluded; the causes of differences between individuals remain unknown. 相似文献
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What determines the invasiveness of introduced plants is still poorly known. Many of the most invasive plant species are clonal, and physiological integration between connected individuals (ramets) of clonal plants may contribute to their ability to spread into communities and reduce performance of existing species. This contribution of integration to the invasiveness of clonal plants may be greater in denser communities. A greenhouse study was conducted to test these two hypotheses. High- and low-density communities were created by sowing seeds of eight grassland species. Each community was planted with three ramets of the stoloniferous, introduced plant Alternanthera philoxeroides that were disconnected from or left connected to ramets growing on bare soil. Connection increased the spread of Alternanthera within a community, but did not reduce community biomass. Alternanthera grew less in high-density communities, but connection did not improve its growth more than in low-density communities. Low-density communities had higher evenness when Alternanthera was connected than when it was disconnected because shoot mass was lower in the more abundant species in the community and higher in the less abundant ones. These results partly supported the first hypothesis, but not the second. The effect of integration on community structure could be due to higher resource import by the ramets of Alternanthera closer to the dominant species. Integration therefore can increase the initial spread of new clonal plant species into communities and modify the effects of this spread on community structure. 相似文献
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Jürgen Heinze Bert Hölldobler & Gary Alpert 《Ethology : formerly Zeitschrift fur Tierpsychologie》1999,105(8):701-717
The myrmicine ant Eutetramorium mocquerysi Emery from Madagascar exhibits a unique social organization. All female individuals are similar in size and appearance; female reproductives with a distinct external morphology do not exist. Based on ovarian anatomy, however, two major types of females can be distinguished: females with six ovarioles and a spermatheca, which can mate and produce diploid offspring, and females with only two ovarioles, which lack a spermatheca but can lay unfertilized eggs. Individuals with three to five ovarioles are rare. Anatomical differences are not correlated with different roles. Both types of females were observed foraging, tending brood, and laying eggs. However, only females with six ovarioles and a spermatheca were the reproductively and socially most dominant individuals. Nestmate antagonism, which for the first time is demonstrated for an ant species belonging neither to the Ponerinae nor the Formicoxenini, consists of biting, antennation bouts, and ritualized dominance postures. In two colonies, removal of the dominant individual resulted in the destruction of all larvae and pupae. 相似文献