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排序方式: 共有164条查询结果,搜索用时 375 毫秒
161.
162.
B Al Aloul M Mbai S Adabag S Garcia S Goldman W Holman G Sethi R Kelly HB Ward EO McFalls 《BMC cardiovascular disorders》2012,12(1):62
ABSTRACT: BACKGROUND: The value of Single Photon Emission Computed Tomography stress myocardial perfusion imaging (SPECT-MPI) for detecting graft disease after coronary artery bypass surgery (CABG) has not been studied prospectively in an unselected cohort. METHODS: Radial Artery Versus Saphenous Vein Graft Study is a Veterans Affairs Cooperative Study to determine graft patency rates after CABG surgery. Seventy-nine participants agreed to SPECT-MPI within 24 hours of their coronary angiogram, one-year after CABG. The choice of the stress protocol was made at the discretion of the nuclear radiologist and was either a symptom-limited exercise test (n=68) or an adenosine infusion (n=11). The SPECT-MPI results were interpreted independent of the angiographic results and estimates of sensitivity, specificity and accuracy were based on the prediction of a graft stenosis of [greater than or equal to]70% on coronary angiogram. RESULTS: A significant stenosis was present in 38 (48%) of 79 patients and 56 (22%) of 251 grafts. In those stress tests with an optimal exercise heart rate response (>80% maximum predicted heart rate) (n=26) sensitivity, specificity and accuracy of SPECT-MPI for predicting the graft stenosis was 77%, 69% and 73% respectively. With adenosine (n=11) it was 75%, 57% and 64%, respectively. Among participants with a suboptimal exercise heart rate response, the sensitivity of SPECT-MPI for predicting a graft stenosis was <50%. The accuracy of SPECTMPI for detecting graft disease did not vary significantly with ischemic territory. CONCLUSIONS: Under optimal stress conditions, SPECT-MPI has a good sensitivity and accuracy for detecting graft disease in an unselected patient population 1 year post-CABG. 相似文献
163.
Usman Sayeed Gulshan Wadhwa M Kalim A Khan Qazi Mohd Sajid Jamal Salman Akhtar M Salman Khan 《Bioinformation》2014,10(8):496-501
Japanese encephalitis (JE) is an acute viral infection of the central nervous system where the JE virus infects the lumen of
the endoplasmic reticulum (ER) and rapidly accumulates substantial amount of seven different nonstructural proteins (NS). These
NS proteins tend to bind on a glycoprotein receptor, ribophorin (RPN) resulting in the malfunctioning of ER in host cells,
subsequently triggering an unfolded protein response. Therefore, it is of interest to predict the best possible antigenic determinants
in the NS protein capable of eliciting immune response as a strategy to combat JE. Hence, it is our interest to explore the most
potent NS protein among all showing the best possible molecular interaction with the RPN receptor present on ER. However, the
structures of these NS protein and RPN are currently unknown. Thus, we modeled their structures using the established homology
modeling techniques in the MODELLER 9v10 software. The molecular docking of NS proteins with RPN was subsequently
completed using the Discovery Studio 2.5 software suite. The docked conformations of RPN with NS were further analyzed and its
graphical interpretations were presented for identifying the most potential NS protein for efficient epitope activity. Further, the B
cell epitopes were mapped using BCPred and the predicted epitope regions are documented. The data presented in this report
provides useful insights towards the design and development of potential epitopes to generate a vaccine candidate against JEV. 相似文献
164.
Genetic variation assessment of acid lime accessions collected from south of Iran using SSR and ISSR molecular markers 总被引:1,自引:0,他引:1
Ata Allah Sharafi Asad Asadi Abkenar Ali Sharafi Mohammad Masaeli 《Physiology and Molecular Biology of Plants》2016,22(1):87-95
Iran has a long history of acid lime cultivation and propagation. In this study, genetic variation in 28 acid lime accessions from five regions of south of Iran, and their relatedness with other 19 citrus cultivars were analyzed using Simple Sequence Repeat (SSR) and Inter-Simple Sequence Repeat (ISSR) molecular markers. Nine primers for SSR and nine ISSR primers were used for allele scoring. In total, 49 SSR and 131 ISSR polymorphic alleles were detected. Cluster analysis of SSR and ISSR data showed that most of the acid lime accessions (19 genotypes) have hybrid origin and genetically distance with nucellar of Mexican lime (9 genotypes). As nucellar of Mexican lime are susceptible to phytoplasma, these acid lime genotypes can be used to evaluate their tolerance against biotic constricts like lime “witches’ broom disease”. 相似文献