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121.
Alison Leitch 《Ethnos》2013,78(4):437-462
This paper explores the emergence of the Slow Food Movement, an international consumer movement dedicated to the protection of ‘endangered foods.’ The history of one of these ‘endangered foods’, lardo di Colonnata, provides the ethnographic window through which I examine Slow Food's cultural politics. The paper seeks to understand the politics of ‘slowness’ within current debates over European identity, critiques of neo-liberal models of rationality, and the significant ideological shift towards market-driven politics in advanced capitalist societies. 相似文献
122.
Adrian A. Garda Helga C. Wiederhecker Alison M. Gainsbury Gabriel C. Costa R. Alexander Pyron Gustavo H. Calazans Vieira Fernanda P. Werneck Guarino R. Colli 《Biotropica》2013,45(2):245-252
We investigate the role of ecology and phylogeny in the association between lizard abundance and microhabitat variables in an Amazon rain forest site. Using pitfall trap arrays, we collected data from 349 individuals belonging to 23 lizard species. After accounting for spatial autocorrelation and using a canonical correspondence analysis (CCA), we found that lizard captures were significantly associated with microhabitat variables, which accounted for 48 percent of the observed variation. Furthermore, a canonical phylogenetic ordination (CPO) indicated that microhabitat variables are more important in determining the distribution of lizard species than phylogenetic relationships among species. Termite nests, canopy openness, and tree circumference were strongly associated with the number of captures of certain lizard species. Our results confirm autecology studies of individual lizard species for which data are available. We suggest that maintaining heterogeneous forested microhabitats should be a central goal for sustaining a high lizard biodiversity in Amazon rain forests. 相似文献
123.
Hung-Chun Yu Jennifer L. Sloan Gunter Scharer Alison Brebner Anita M. Quintana Nathan P. Achilly Irini Manoli Curtis R. Coughlin II Elizabeth A. Geiger Una Schneck David Watkins Terttu Suormala Johan L.K. Van Hove Brian Fowler Matthias R. Baumgartner David S. Rosenblatt Charles P. Venditti Tamim H. Shaikh 《American journal of human genetics》2013
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Andrew R. Williams Sara E. Zakutansky Kazutoyo Miura Matthew D.J. Dicks Thomas S. Churcher Kerry E. Jewell Aisling M. Vaughan Alison V. Turner Melissa C. Kapulu Kristin Michel Carole A. Long Robert E. Sinden Adrian V.S. Hill Simon J. Draper Sumi Biswas 《International journal for parasitology》2013
The mosquito innate immune response is able to clear the majority of Plasmodium parasites. This immune clearance is controlled by a number of regulatory molecules including serine protease inhibitors (serpins). To determine whether such molecules could represent a novel target for a malaria transmission-blocking vaccine, we vaccinated mice with Anopheles gambiae serpin-2. Antibodies against Anopheles gambiae serpin-2 significantly reduced the infection of a heterologous Anopheles species (Anopheles stephensi) by Plasmodium berghei, however this effect was not observed with Plasmodium falciparum. Therefore, this approach of targeting regulatory molecules of the mosquito immune system may represent a novel approach to transmission-blocking malaria vaccines. 相似文献
126.
Alison Baker 《Molecular membrane biology》2013,30(1-2):1-2
The interactions of mouse thymocytes with unilamellar phospholipid vesicles comprised of dimyristyl lecithin (DML), dipalmitoyl lecithin (DPL), dioleoyl lecithin (DOL), and egg yolk lecithin (EYL) were examined in vitro.In cells treated with [3H]DML or [3H]DPL vesicles, electron microscope (EM) autoradiographic analysis showed most of the radioactive lipids to be confined to the cell surface. Transmission EM studies showed the presence of intact vesicles (DPL) and collapsed or ruptured vesicle fragments (DML) adsorbed to the surfaces of treated cells. In cells treated with DPL vesicles containing a watersoluble dye (6-carboxyfluorescein; 6-CF), most of the fluorescent vesicles were localized at the periphery of the treated cells. Furthermore, substantial fractions of the cell-associated DPL and DML could be released by a mild trypsinization without damaging the cells. These results suggest that the uptake of DML and DPL is primarily due to vesicle-cell adsorption. Such an adsorption process appears to be enhanced at or below the thermotropic-phase transition temperature of the vesicle lipid. Under certain conditions these adherent vesicles also formed patches or caps on the cell surface.In cells treated with DOL or EYL vesicles, transmission EM and EM autoradiography showed relatively little exogenous vesicle lipid located at the cell surface. Thymocytes incubated (37°C) with [14C] EYL vesicles containing a trapped marker, [3H]inulin, incor porated both isotopes at identical rates. In separate experiments it was found that this marker was located inside the treated cells. Thymocytes treated with DOL vesicles containing 6-CF exhibited a uniform and diffuse distribution of dye in the internal volume of the cells. Little cell-associated EYL or DOL could be released by trypsinization. Evidence against endocytosis of intact vesicles as a major pathway of vesicle uptake is also presented. These observations, coupled with the demonstration of vesicle-cell lipid exchange as a minor component of vesicle uptake suggest that incorporation of EYL and DOL vesicles by thymocytes is primarily by vesicle-cell fusion. 相似文献
127.
Cassandra L.A. Hawco Estelle Marchal Md. Imam Uddin Alexander E.G. Baker Dale P. Corkery Graham Dellaire Alison Thompson 《Bioorganic & medicinal chemistry》2013,21(19):5995-6002
To generate the first series of prodigiosene conjugates, the tripyrrolic skeleton was appended to estrone, tamoxifen and porphyrin frameworks by way of ester linkers and various hydrocarbon chain lengths. The ability of the conjugates to inhibit various types of cancer cells was evaluated in vitro. The porphyrin conjugates did not exhibit significant activity. The estrone conjugates exhibited modest activity, for the most part. However, significantly greater growth inhibition activity against certain breast, colon, lung, leukemia, melanoma and prostate cell lines was noted. This unusual effect for this first generation model class of compound warrants further investigation and comparison to cases where estrogens are linked to prodigiosenes via connection points that do not feature in estrogen receptor binding. The 4-hydroxytamoxifen conjugates exhibit nanomolar range activity against the MCF-7 breast cancer cell line, paving the way to expand the scope and connectivity of prodigiosene–tamoxifen conjugates. 相似文献
128.
Thomas T.Y. Wang Alison J. Edwards Beverly A. Clevidence 《The Journal of nutritional biochemistry》2013,24(8):1538-1546
The mechanisms as well the genetics underlying the bioavailability and metabolism of carotenoids in humans remain unclear. To begin to address these questions, we used cluster analysis to examine individual temporal responses of plasma carotenoids from a controlled-diet study of subjects who consumed carotenoid-rich beverages. Treatments, given daily for 3 weeks, were watermelon juice at two levels (20-mg lycopene, 2.5-mg β-carotene, n=23 and 40-mg lycopene, 5-mg β-carotene, n=12) and tomato juice (18-mg lycopene, 0.6-mg β-carotene, n=10). Cluster analysis revealed distinct groups of subjects differing in the temporal response of plasma carotenoids and provided the basis for classifying subjects as strong responders or weak responders for β-carotene, lycopene, phytoene and phytofluene. Individuals who were strong or weak responders for one carotenoid were not necessarily strong or weak responders for another carotenoid. Furthermore, individual responsiveness was associated with genetic variants of the carotenoid metabolizing enzyme β-carotene 15,15'-monooxygenase 1. These results support the concept that individuals absorb or metabolize carotenoids differently across time and suggest that bioavailability of carotenoids may involve specific genetic variants of β-carotene 15,15'-monooxygenase 1. 相似文献
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