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961.
962.
963.
Ángel Urzúa Guillermo Guerao Jose A. Cuesta Guiomar Rotllant Alicia Estévez Klaus Anger 《Marine and Freshwater Behaviour and Physiology》2013,45(6):381-397
Palaemonetes zariquieyi, an endemic palaemonid species of shrimp that lives in freshwater and brackish coastal habitats in eastern Spain, shows an abbreviated, non-feeding larval development comprising only three zoeal stages. To identify the endogenous bioenergetic fuel that allows for food-independent development from hatching to metamorphosis, larvae were reared under controlled laboratory conditions, and ontogenetic changes in dry weight (W), elemental (CHN), and lipid composition (total lipids, principal lipid classes, and fatty acids [FA]) were quantified at the onset of each zoeal stage and in the first juvenile. Values of W, C, and H per larva and per mass unit of W decreased throughout the time of larval development, while the N content showed only a weak decline (suggesting strong lipid but only little protein degradation). Correspondingly, directly measured values of total lipids (both in μg/larva and in % of W) decreased gradually, with neutral lipids (NL) consistently remaining the predominant and most strongly used fraction; sterol esters and waxes were not detected. In contrast to the NL, the fraction of polar lipids (PL) per larva remained stable and, as a consequence, tended to increase as a percentage of total lipids. Likewise, other important lipid fractions such as free FA and cholesterol remained stable throughout the time of larval development. Among the FA, palmitic (16:0), oleic (18:1n–9), linoleic (18:2n–6), and eicosapentaenoic (20:5n–3) acid were predominant, showing a significant decrease during larval development; stearic (18:0), vaccenic (18:1n–7), and arachidonic acid (20:4n–6) were found only in small amounts. Our results indicate that the lecithotrophic development of P. zariquieyi is primarily fuelled by the utilization of lipids (especially triacylglycerides and other NL), which is reflected by a decreasing carbon content. Proteins and PL, by contrast, are preserved as structurally indispensable components (nerve and muscle tissues, cell membranes). The abbreviated and non-feeding mode of larval development of P. zariquieyi may have an adaptive value in land-locked freshwater habitats, where planktonic food limitation is likely to occur. The patterns of reserve utilization are similar to those previously observed in other palaemonid shrimps and various other groups of decapod crustaceans with lecithotrophic larvae. This suggests a multiple convergent evolution of bioenergetic traits allowing for reproduction in food-limited aquatic environments. 相似文献
964.
Soresi Daniela Bagnaresi Paolo Crescente Juan Manuel Díaz Marina Cattivelli Luigi Vanzetti Leonardo Carrera Alicia 《Plant Molecular Biology Reporter》2021,39(4):710-726
Plant Molecular Biology Reporter - Qfhs.ndsu-3AS in wild emmer wheat (Triticum turgidum L. ssp. dicoccoides) is a major quantitative trait locus associated with type II resistance to Fusarium head... 相似文献
965.
966.
Ercoli Marcos D. Álvarez Alicia Youlatos Dionisios Moyano S. Rocío Candela Adriana M. 《Journal of Mammalian Evolution》2021,28(2):411-433
Journal of Mammalian Evolution - The caudal cranium and occipito-cervical region, although usually overlooked, are informative about the paleobiology of fossil mammals, allowing inquiry into vision... 相似文献
967.
Marina GM Viturino Jamil M Neto Flvia F Bajano Sueli MS Costa Alicia B Roque Gessica FS Borges Galina Ananina Priscila HH Rim Flvio M Medina Fernando F Costa Jos PC de Vasconcellos Mnica B de Melo 《Experimental biology and medicine (Maywood, N.J.)》2021,246(10):1148
This study aimed to evaluate the role of APOE polymorphisms (rs429358 and rs7412) in the risk of age-related macular degeneration in a sample of the Southeastern Brazilian population. Seven hundred and five unrelated individuals were analyzed, 334 with age-related macular degeneration (case group), and 371 without the disease (control group). In the case group, patients were further stratified according to disease phenotypes, divided into dry and wet age-related macular degeneration, and non-advanced and advanced age-related macular degeneration. APOE polymorphisms (rs429358 and rs7412) were evaluated through polymerase chain reaction and direct sequencing. In the comparison of cases vs. controls, none of the associations reached statistical significance, considering the Bonferroni-adjusted P-value, although there was a suggestive protection for the E3/E4 genotype (OR = 0.626; P-value = 0.037) and E4 carriers (OR = 0.6515; P-value = 0.047). Statistically significant protection for both the E3/E4 genotype and E4 carriers was observed in the comparisons: advanced age-related macular degeneration vs. controls (OR = 0.3665, P-value = 0.491 × 10−3 and OR = 0.4031, P-value = 0.814 × 10−3, respectively), advanced age-related macular degeneration vs. non-advanced age-related macular degeneration (OR = 0.2529, P-value = 0.659 × 10−4 and OR = 0.2692, P-value = 0.631 × 10−4, respectively). In the comparison of wet age-related macular degeneration vs. control, protection was statistically significant only for E3/E4 (OR = 0.4052, P-value = 0.001). None of the comparisons demonstrated any significant association for E2 genotypes or E2 carriers in age-related macular degeneration risk in this study. Findings suggest a protective role of the E4 haplotype in the APOE gene in the risk for advanced and wet forms of age-related macular degeneration, in a sample of the Brazilian population. To our knowledge, this is the first Brazilian study to show the association between APOE polymorphisms and age-related macular degeneration. 相似文献
968.
Martínez-Luis S Cherigo L Higginbotham S Arnold E Spadafora C Iba?ez A Gerwick WH Cubilla-Rios L 《International microbiology》2011,14(2):95-102
Many compounds produced by fungi have relevant pharmaceutical applications. The purpose of this study was to collect and isolate endophytic fungi from different regions of Panama and then to test their potential therapeutic activities against Leishmania donovani, Plasmodium falciparum, and Trypanosoma cruzi as well as their anticancer activities in MCF-7 cells. Of the 25 fungal isolates obtained, ten of them had good anti-parasitic potential, showing selective activity against L. donovani; four had significant anti-malarial activity; and three inhibited the growth of T. cruzi. Anticancer activity was demonstrated in four isolates. Of the active isolates, Edenia sp. strain F0755, Xylaria sp. strain F1220, Aspergillus sp. strain F1544, Mycoleptodiscus sp. strain F0194, Phomopsis sp. strain F1566, Pycnoporus sp. strain F0305, and Diaporthe sp. strain F1647 showed the most promise based on their selective bioactivity and lack of toxicity in the assays. 相似文献
969.
Kowaltowski AJ 《Redox report : communications in free radical research》2011,16(6):237-241
Calorie restriction (CR) is well established to enhance the lifespan of a wide variety of organisms, although the mechanisms are still being uncovered. Recently, some authors have suggested that CR acts through hormesis, enhancing the production of reactive oxygen species (ROS), activating stress response pathways, and increasing lifespan. Here, we review the literature on the effects of CR and redox state. We find that there is no evidence in rodent models of CR that an increase in ROS production occurs. Furthermore, results in Caenorhabditis elegans and Saccharomyces cerevisiae suggesting that CR increases intracellular ROS are questionable, and probably cannot be resolved until adequate, artifact free, tools for real-time, quantitative, and selective measurements of intracellular ROS are developed. Overall, the largest body of work indicates that CR improves redox state, although it seems improbable that a global improvement in redox state is the mechanism through which CR enhances lifespan. 相似文献
970.
Giansanti V Torriglia A Scovassi AI 《Apoptosis : an international journal on programmed cell death》2011,16(4):321-333
Drug resistance of cancer cells is often correlated with apoptosis evasion; however, an active involvement of autophagy in
this scenario has been recently proposed, based on the evidence that autophagy could exert a protective role toward the activation
of apoptosis in cancer cells. In this review, we briefly review the basic features of apoptosis, and we describe in details
the molecular patterns of autophagy, with a special emphasis on its still controversial physiological function(s). The crucial
factors governing the cross talk between autophagy and apoptosis will be illustrated. 相似文献