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181.
M Bodo E Becchetti F Pezzetti T Baroni M Calvitti F A Alia N Arena 《Cellular and molecular biology, including cyto-enzymology》1990,36(6):673-687
The administration of lectin concanavalin A (Con A) to in vitro cultures of chick embryo fibroblasts caused dose-dependent changes in cell shape, cytoskeleton network and DNA synthesis. After 6 hrs. even a low doses of Con A produced evident effects in serum-free cultures, whereas higher doses were required to cause alterations in cells cultured in serum-added medium. As the sugar competitor mannoside abolishes the effects, it would seem that the lectin acts by binding to transmembrane receptors and that the fibronectin present in the serum engages the receptors so that they are not available to Con A. 相似文献
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185.
M Bodo N Arena F Pezzetti T Baroni M Calvitti F A Alia E Becchetti 《Cellular and molecular biology, including cyto-enzymology》1990,36(6):689-703
The present research investigated the time required for reconstructing normal microtubular pattern and the phenotype of cells after short-term (30 min.) and long-term (24 hrs.) pretreatment with the lectin concanavalin A (Con A). Short-term pretreatment led to the formation of incomplete tubules within 2 and 24 hrs. in cells cultured in 199 medium alone. The addition of serum to the medium reversed the globular phenotype and allowed the formation of normal microtubules, even after prolonged pretreatment with Con A. Whereas long-term Con A treatment provoked a reduction in DNA synthesis in 199 alone, in serum-added 199 the percentage of 3H-thymidine incorporation of treated cells tended to reach that of controls over time. 相似文献
186.
D. G. Butler M. Z. Alia Cadinouche 《Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology》1995,165(5):348-358
Renal function was observed in freshwater North American eels (Anguilla rostrata LeSueur) 2 weeks after the removal of the corpuscles of Stannius. There was a positive linear correlation between glomerular filtration rates and urine flow rates in both sham-operated and stanniectomized eels but there was no difference in slope or elevation between the two groups nor did urine flow rates ever exceed glomerular filtration rates. Osmolar clearance and free-water clearance were unchanged following stanniectomy. Plasma Ca2+ and K+ concentrations increased and plasma Mg2+, phosphate, Na+ and Cl- concentrations decreased following stanniectomy. Plasma ultrafilterable Ca increased and ultrafilterable Mg decreased after stanniectomy but neither changed relative to its total plasma concentration. Stanniectomy was followed by a decreased renal tubular reabsorption of Mg2+ relative to the amount filtered (C
Mg/C
In); the same applies to C
Na/C
In. Even though the filtered load of Ca increased in conjuction with the predictable hypercalcemia, there was no change in the fraction of filtered Ca reabsorbed. Net tubular secretion of phosphate was observed in both sham-operated and stanniectomized cels together with a slight increase in C
phos/C
In following stanniectomy. Some or all of these changes in plasma electrolytes and/or the modified renal transport of Na+, Mg2+ and possibly phosphate may be caused by the changes in cardiovascular function that were recently shown to follow stanniectomy.Abbreviations
CSX
Stanniectomized/stanniectomy
-
ER
endoplasmatic reticulum
-
FW
fresh water
-
GFR
glomerular filtration rate
-
Pi
inorganic phosphate
-
RAS
renin-angiotensin system
-
SHM
sham-operated
-
SW
sea water
-
UFR
urine flow rate
-
U/P ratio
urine/plasma ratio 相似文献
187.
188.
Daniel R. Jacobson R. Pastore Stephen Pool Slawomir Malendowicz Immaculata Kane Alia Shivji Stephen H. Embury Samir K. Ballas J. N. Buxbaum 《Human genetics》1996,98(2):236-238
The transthyretin (TTR) Ile 122 variant is associated with cardiac amyloidosis in individuals of African descent. To determine
the prevalence of the allele encoding TTR Ile 122 in African-Americans, we have used PCR and restriction analysis to test
DNA from African-Americans from various geographic areas, and found an allele frequency of 66/3376 (0.020), which is higher
than the value we previously reported in a much smaller pilot study. Our data indicate that this TTR variant is present at
equal frequency in African-Americans throughout the U.S., and suggest that this mutation may be a common, often unrecognized
cause of cardiac disease in African-Americans.
Received: 23 January 1996 相似文献