全文获取类型
收费全文 | 11479篇 |
免费 | 659篇 |
国内免费 | 32篇 |
出版年
2024年 | 17篇 |
2023年 | 118篇 |
2022年 | 344篇 |
2021年 | 597篇 |
2020年 | 396篇 |
2019年 | 530篇 |
2018年 | 540篇 |
2017年 | 388篇 |
2016年 | 535篇 |
2015年 | 599篇 |
2014年 | 718篇 |
2013年 | 909篇 |
2012年 | 928篇 |
2011年 | 822篇 |
2010年 | 487篇 |
2009年 | 409篇 |
2008年 | 500篇 |
2007年 | 493篇 |
2006年 | 437篇 |
2005年 | 416篇 |
2004年 | 327篇 |
2003年 | 270篇 |
2002年 | 242篇 |
2001年 | 111篇 |
2000年 | 100篇 |
1999年 | 81篇 |
1998年 | 60篇 |
1997年 | 34篇 |
1996年 | 39篇 |
1995年 | 43篇 |
1994年 | 28篇 |
1993年 | 29篇 |
1992年 | 47篇 |
1991年 | 43篇 |
1990年 | 46篇 |
1989年 | 43篇 |
1988年 | 45篇 |
1987年 | 33篇 |
1986年 | 31篇 |
1985年 | 37篇 |
1984年 | 33篇 |
1983年 | 27篇 |
1982年 | 21篇 |
1981年 | 26篇 |
1980年 | 16篇 |
1979年 | 16篇 |
1978年 | 19篇 |
1977年 | 14篇 |
1976年 | 22篇 |
1975年 | 17篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
991.
992.
993.
Co‐culture of bone marrow‐derived mesenchymal stem cells overexpressing lipocalin 2 with HK‐2 and HEK293 cells protects the kidney cells against cisplatin‐induced injury
下载免费PDF全文
![点击此处可从《Cell biology international》网站下载免费的PDF全文](/ch/ext_images/free.gif)
994.
995.
996.
This study was conducted to identify environmental and human health risks caused by Balarood Dam, in construction phrase. The first step, all risk-generating factors were identified using a Delphi Questionnaire. Afterwards, the identified criteria were prioritized once using the Analytical Hierarchy Process (AHP) method and then by the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS). Due to the complex and uncertain nature of decision-making in times of risk, it was necessary to use more than one weighting method to ensure accuracy of weights. The results from AHP and TOPSIS revealed a mismatch in priorities; therefore, an integration method was presented blending Mean-Rank, Borda, and Copeland methods. According to the TOPSIS results, factors including cut and fill, explosion, and transportation, were first to third highest-priority risk-generating factors, respectively. Considering the results from the AHP method, factors cut and fill, drilling, and explosion were identified as first to third top-priority risk-generating factors, respectively. The results obtained from the integration method suggested that cut and fill, explosion, and drilling are the most important environmental risks at construction phase. As a general conclusion, different weighting methods can lead to different results by which the fate of a decision may be changed and it is essential to control final scores by applying more than one weighting method. 相似文献
997.
Reza Heidari Hossein Niknahad Akram Jamshidzadeh Negar Azarpira Mandana Bazyari Asma Najibi 《Journal of biochemical and molecular toxicology》2015,29(4):173-181
Liver injury is a deleterious adverse effect associated with methimazole administration, and reactive intermediates are suspected to be involved in this complication. Glyoxal is an expected reactive intermediate produced during methimazole metabolism. Current investigation was undertaken to evaluate the role of carnosine, metformin, and N‐acetyl cysteine as putative glyoxal (carbonyl) traps, against methimazole‐induced hepatotoxicity. Methimazole (100 mg/kg, intraperitoneally) was administered to intact and/or glutathione (GSH)?depleted mice and the role of glyoxal trapping agents was investigated. Methimazole caused liver injury as revealed by an increase in serum alanine aminotransferase and aspartate aminotransferase. Moreover, lipid peroxidation and protein carbonylation occurred significantly in methimazole?treated animals’ liver. Hepatic GSH reservoirs were decreased, and inflammatory cells infiltration was observed in liver histopathology. Methimazole?induced hepatotoxicity was severe in GSH‐depleted mice and accompanied with interstitial hemorrhage and necrosis of the liver. Glyoxal trapping agents effectively diminished methimazole‐induced liver injury both in intact and/or GSH?depleted animals. 相似文献
998.
Protective Effects of Caffeic Acid Phenethyl Ester on Cyclophosphamide‐Induced Hemorrhagic Cystitis in Rats
下载免费PDF全文
![点击此处可从《Journal of biochemical and molecular toxicology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ersin Uysal H. Ramazan Yılmaz Yunus Ugan Atila Altuntas Atalay Dogru Ali Kutlucan Sevket Ercan Tunc 《Journal of biochemical and molecular toxicology》2015,29(12):559-563
We investigated the protective effect of caffeic acid phenethyl ester (CAPE) on cyclophosphamide‐induced hemorrhagic cystitis in rats in comparison with 2‐mercaptoethane sulfonate (MESNA). Forty male rats were randomized into four groups: group 1 (control), group 2 (cyclophosphamide), group 3 (cyclophosphamide + MESNA), group 4 (cyclophosphamide + CAPE). Cyclophosphamide injection increased malondialdehyde levels indicating oxidative stress, whereas CAPE and MESNA ameliorated malondialdehyde levels in the bladder (p < 0.05). Only catalase activities were decreased significantly in both groups (cyclophosphamide + MESNA and cyclophosphamide + CAPE, p < 0.05). Pretreatment with CAPE (p < 0.01) resulted in a significant decrease in nitric oxide levels when compared with the cyclophosphamide group. When we consider the studies that show the critical importance of increased nitric oxide levels in pathogenesis of cyclophosphamide‐induced hemorrhagic cystitis, we suggest that it would be more beneficial to use MESNA with CAPE to prevent histological damage. 相似文献
999.
1000.