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951.
Khajehdehi Mina Khalaj-Kondori Mohammad Hosseinpour Feizi Mohammad Ali 《Molecular biology reports》2022,49(7):6075-6084
Molecular Biology Reports - Aberrant expressions of long non-coding RNAs promote cancer development including colorectal cancer. Expression profiling of cancer-related lncRNAs may introduce new... 相似文献
952.
Gholipour Akram Shakerian Farshad Zahedmehr Ali Oveisee Maziar Maleki Majid Mowla Seyed Javad Malakootian Mahshid 《Molecular biology reports》2022,49(10):9267-9273
Molecular Biology Reports - Coronary artery disease (CAD), is the leading cause of mortality and morbidity worldwide. Tenascin-C (TNC) with high expression levels in inflammatory and cardiovascular... 相似文献
953.
Gharbi Dorra Mobayed Hassan M. Ali Ramzy Mohammed Tuffaha Amjad Dason Blessing Reena Ibrahim Tayseer Adeli Mehdi Sattar Hisham A. Trigo Maria del Mar Al-Nesf Maryam Ali 《Aerobiologia》2022,38(3):329-342
Aerobiologia - Daily monitoring of airborne fungal spores was carried out for the first time in Al Khor city, Qatar, using a Hirst type 7-day recording volumetric spore trap, from May 2017 to May... 相似文献
954.
Eryavuz Onmaz Duygu Tezcan Dilek Abusoglu Sedat Sivrikaya Abdullah Kuzu Menekse Yerlikaya Fatma Humeyra Yilmaz Sema Unlu Ali 《Amino acids》2022,54(6):877-887
Amino Acids - Behçet disease (BD) is an inflammatory, multisystemic vasculitis of unknown etiopathogenesis. However, innate and adaptive immune system involvement and immune-mediated networks... 相似文献
955.
Mohammadi Salman Shafiee Maryam Faraji Seyed Nooreddin Rezaeian Mohsen Ghaffarian-Bahraman Ali 《Biometals》2022,35(4):711-728
BioMetals - Breast milk is a complete food for the development of the newborn, but it can also be an important route for environmental pollutants transmission to the infants. This study was aimed... 相似文献
956.
Ghorbanpour Monireh Soltani Behzad Mota Ali Jahanbin Sardroodi Jaber Mehdizadeh Aghdam Elnaz Shayanfar Ali Molavi Ommoleila Mohammad-Rezaei Rahim Ebadi-Nahari Mostafa Ziegler Christopher J. 《Biometals》2022,35(5):1095-1111
BioMetals - A group of bidentate nitrogen and sulfur donor pyrazole derivative ligands abbreviated as Na[RNCS(Pz)], Na[RNCS(PzMe2)], Na[RNCS(PzMe3)], Na[RNCS(PzPhMe)], Na[RNCS(PzPh2)], where... 相似文献
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Meiru Si Lei Zhang Muhammad Tausif Chaudhry Wei Ding Yixiang Xu Can Chen Ali Akbar Xihui Shen Shuang-Jiang Liu 《Applied and environmental microbiology》2015,81(8):2781-2796
Oxidation of methionine leads to the formation of the S and R diastereomers of methionine sulfoxide (MetO), which can be reversed by the actions of two structurally unrelated classes of methionine sulfoxide reductase (Msr), MsrA and MsrB, respectively. Although MsrAs have long been demonstrated in numerous bacteria, their physiological and biochemical functions remain largely unknown in Actinomycetes. Here, we report that a Corynebacterium glutamicum methionine sulfoxide reductase A (CgMsrA) that belongs to the 3-Cys family of MsrAs plays important roles in oxidative stress resistance. Deletion of the msrA gene in C. glutamicum resulted in decrease of cell viability, increase of ROS production, and increase of protein carbonylation levels under various stress conditions. The physiological roles of CgMsrA in resistance to oxidative stresses were corroborated by its induced expression under various stresses, regulated directly by the stress-responsive extracytoplasmic-function (ECF) sigma factor SigH. Activity assays performed with various regeneration pathways showed that CgMsrA can reduce MetO via both the thioredoxin/thioredoxin reductase (Trx/TrxR) and mycoredoxin 1/mycothione reductase/mycothiol (Mrx1/Mtr/MSH) pathways. Site-directed mutagenesis confirmed that Cys56 is the peroxidatic cysteine that is oxidized to sulfenic acid, while Cys204 and Cys213 are the resolving Cys residues that form an intramolecular disulfide bond. Mrx1 reduces the sulfenic acid intermediate via the formation of an S-mycothiolated MsrA intermediate (MsrA-SSM) which is then recycled by mycoredoxin and the second molecule of mycothiol, similarly to the glutathione/glutaredoxin/glutathione reductase (GSH/Grx/GR) system. However, Trx reduces the Cys204-Cys213 disulfide bond in CgMsrA produced during MetO reduction via the formation of a transient intermolecular disulfide bond between Trx and CgMsrA. While both the Trx/TrxR and Mrx1/Mtr/MSH pathways are operative in reducing CgMsrA under stress conditions in vivo, the Trx/TrxR pathway alone is sufficient to reduce CgMsrA under normal conditions. Based on these results, a catalytic model for the reduction of CgMsrA by Mrx1 and Trx is proposed. 相似文献