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101.
C Allard V Desgagné J Patenaude M Lacroix L Guillemette MC Battista M Doyon J Ménard JL Ardilouze P Perron L Bouchard MF Hivert 《Epigenetics》2015,10(4):342-351
Leptin is an adipokine that acts in the central nervous system and regulates energy balance. Animal models and human observational studies have suggested that leptin surge in the perinatal period has a critical role in programming long-term risk of obesity. In utero exposure to maternal hyperglycemia has been associated with increased risk of obesity later in life. Epigenetic mechanisms are suspected to be involved in fetal programming of long term metabolic diseases. We investigated whether DNA methylation levels near LEP locus mediate the relation between maternal glycemia and neonatal leptin levels using the 2-step epigenetic Mendelian randomization approach. We used data and samples from up to 485 mother-child dyads from Gen3G, a large prospective population-based cohort. First, we built a genetic risk score to capture maternal glycemia based on 10 known glycemic genetic variants (GRS10) and showed it was an adequate instrumental variable (β = 0.046 mmol/L of maternal fasting glucose per additional risk allele; SE = 0.007; P = 7.8 × 10−11; N = 467). A higher GRS10 was associated with lower methylation levels at cg12083122 located near LEP (β = −0.072 unit per additional risk allele; SE = 0.04; P = 0.05; N = 166). Direction and effect size of association between the instrumental variable GRS10 and methylation at cg12083122 were consistent with the negative association we observed using measured maternal glycemia. Lower DNA methylation levels at cg12083122 were associated with higher cord blood leptin levels (β = −0.17 log of cord blood leptin per unit; SE = 0.07; P = 0.01; N = 170). Our study supports that maternal glycemia is part of causal pathways influencing offspring leptin epigenetic regulation. 相似文献
102.
103.
Martin Ve
ea Jan Divíek Jonathan Lenoir Borja Jimnez‐Alfaro Idoia Biurrun Ilona Knollov Emiliano Agrillo Juan Antonio Campos Andra arni Guillermo Crespo Jimnez Mirjana uk Panayotis Dimopoulos Jrg Ewald Federico Fernndez‐Gonzlez Jean‐Claude Ggout Adrian Indreica Ute Jandt Florian Jansen Zygmunt Kcki Valerijus Raomavi
ius Marcela ezní
kov John S. Rodwell Joop H.J. Schamine Urban ilc Jens‐Christian Svenning Grzegorz Swacha Kiril Vassilev Roberto Venanzoni Wolfgang Willner Thomas Wohlgemuth Milan Chytrý 《Journal of Biogeography》2019,46(9):1919-1935
104.
Sandra Vacas Cristina Alfaro Manuel Zarzo Vicente Navarro‐Llopis Jaime Primo 《Entomologia Experimentalis et Applicata》2011,139(3):250-257
Since the discovery of Lobesia botrana Denis & Schiffermüller (Lepidoptera: Tortricidae) sex pheromone, it has played an important role in the control and detection of this pest, for example, through the use of pheromone‐baited traps and mating disruption techniques. Rubber septa are the most common pheromone dispensers used in monitoring traps, but often dispenser performance is not optimized. The key to improve methods based on pheromones as attractants (monitoring, mass trapping, or ‘attract and kill’) is to know the optimum emission interval, because release rates can strongly affect the attraction. In this work, five levels of pheromone load with different release rates were compared in traps using mesoporous pheromone dispensers to investigate the optimum release rate maximizing L. botrana catches. Residual pheromone loads of the dispensers were extracted and quantified by gas chromatography, to study release profiles and to estimate the various emission levels. The efficacy of pheromone emission was measured in field trials as number of moths caught. A quadratic model was fitted to relate the numbers caught vs. the daily emission rates. The resulting quadratic term was statistically significant, confirming the existence of a relative maximum for L. botrana catches. Taking into account that the trial was carried out only in one location, an optimum emission value of ca. 400 μg per day could be considered to enhance the attraction of L. botrana under West‐Mediterranean weather conditions. 相似文献
105.
Dornburg A Sidlauskas B Santini F Sorenson L Near TJ Alfaro ME 《Evolution; international journal of organic evolution》2011,65(7):1912-1926
Innovations in locomotor morphology have been invoked as important drivers of vertebrate diversification, although the influence of novel locomotion strategies on marine fish diversification remains largely unexplored. Using triggerfish as a case study, we determine whether the evolution of the distinctive synchronization of enlarged dorsal and anal fins that triggerfish use to swim may have catalyzed the ecological diversification of the group. By adopting a comparative phylogenetic approach to quantify median fin and body shape integration and to assess the tempo of functional and morphological evolution in locomotor traits, we find that: (1) functional and morphological components of the locomotive system exhibit a strong signal of correlated evolution; (2) triggerfish partitioned locomotor morphological and functional spaces early in their history; and (3) there is no strong evidence that a pulse of lineage diversification accompanied the major episode of phenotypic diversification. Together these findings suggest that the acquisition of a distinctive mode of locomotion drove an early radiation of shape and function in triggerfish, but not an early radiation of species. 相似文献
106.
M.D. Marrodán M. González-Montero de Espinosa Á. Herráez E.L. Alfaro I.F. Bejarano M. Carmenate D.B. Lomaglio N. López-Ejeda A. Martínez M.S. Mesa B. Méndez Pérez J.M. Meléndez S. Moreno-Romero J.L. Pacheco V. Vázquez J.E. Dipierri 《HOMO》2017,68(2):145-155
Subcutaneous fat skinfolds represent a reliable assessment instrument of adiposity status. This study provides current percentile references for four subcutaneous skinfolds (biceps, triceps, subscapular, suprailiac) applicable to children and adolescents in Spain and in Latin American countries where data are scarce.The design consisted of a cross-sectional multicenter study performed with identical methods in 5 countries (Argentina, Cuba, Mexico, Spain and Venezuela). Total sample comprised 9163 children and youths (boys 4615 - girls 4548) aged 6–18 years, healthy and without apparent pathologies. Percentiles 3, 5, 10, 25, 50, 75, 90, 95 and 97 were calculated by the LMS method. Sexual dimorphism was assessed using the t-test and age differences with ANOVA. Normalized growth percentile references were obtained according to sex and age for each skinfold. The mean values of four skinfolds were significantly greater in girls than boys (p < 0.001) and, in both sexes, all skinfolds show statistical differences through age (p < 0.001) with different magnitudes.Except triceps in girls, peaks between 11 and 12 years of age are more noticeable in boys than in girls. Although the general model of growth is known, the skinfold measurements show variability among populations and differences of magnitude are presented according to the analyzed population. Therefore, these age and sex-specific reference percentile values for biceps, triceps, subscapular and suprailiac skinfolds, derived from a large sample of Spanish and Latin American children and adolescents, are a useful tool for adiposity diagnosis in this population for which no reference values were available. 相似文献
107.
The spatial and vertical structure of the water currents and its relationship with the tidal cycles were studied using current meters in the Gulf of Nicoya. In the upper gulf, the vertical marine current differences increase as the depth increases. The water column at the station near Chira Island (upper gulf) shows the smaller changes in currents and in temperature. The flow at the station between San Lucas Island and Puntarenas (middle gulf) is the most stratified in this region. Currents with magnitudes over 100 cm/seg were measured during spring tides. Changes in the lags of the surface and bottom tidal flows were measured on the order of 100 minutes. In general, in this upper region the flows are toward the head of the gulf when the tide is flooding and toward the mouth when the tide is ebbing. In the lower gulf the circulation is more complex. Along an axis between Tárcoles and Negritos Islands, changes of velocity vectors are identified between surface and bottom. The current rotates in a different way in the water column in this region and their patterns cannot be explained only by the tidal cycles predicted for Puntarenas. These results demonstrate that the spatial and vertical variation of the marine currents of the Gulf of Nicoya is not only related to the thermohaline structure, but also to the tidal cycles and tide ranges that take place in this estuary. 相似文献
108.
Using an energy dispersive X-Ray fluorescence analysis, simultaneous evaluation of K, Ca, Ti, Cr, Mn, Ge, Ni, Cu, Zn, Br, Rb, Sr and Pb in 74 marine sediment samples from the Costa Rica intertidal zones was conducted. Samples were collected between June 1999 and December 2001, from Caribbean and Pacific beaches of Costa Rica. Calcium and iron showed the highest abundances and are indicators of the natural origin of the sediments. Calcium is associated with biogenic processes such as coral reefs near the sampling sites and iron indicates a terrigenous origin. In general, the beaches of the Caribbean and North Pacific regions showed the greatest concentration of calcium. This is indicative of the abundant reef structures near these beaches. The beaches of the Central and South Pacific show the greatest iron concentrations, indicating an important lithosphere contribution and/or little contribution of calcium carbonate due to the poor development of coralline structures near the sampling sites. Finally, the analyses did not show evidence of elements associated with anthropogenic pollution. Only a northern section of Puerto Viejo beach showed high concentrations of lead, zinc and titanium, perhaps associated with hydrothermal sources. 相似文献
109.
110.
Peter J. Richerson Patrick J. Neale Wayne Wurtsbaugh T. René Alfaro Warwick Vincent 《Hydrobiologia》1986,138(1):205-220
A statistical analysis is presented of patterns of variation in some physical, chemical, and biological variables for a 6 year series of data from the tropical, high altitude Lake Titicaca (Peru-Bolivia). ANOVA techniques and autocorrelation analyses were used to partition the variance in Titicaca, and in some comparison tropical and temperate series, into components with repeatable annual cycles and components attributable to other kinds of patterns.In Titicaca, insolation and stratification are highly seasonal in pattern of variation, although the amount of variance relative to means is small compared to temperate lakes. However, the seasonal pattern of physical variation is only weakly imposed on chemical and biological processes, to judge from analyses of silicate, oxygen, and primary production series. Comparable temperate series of primary production and chlorophyll a are much more seasonal. 相似文献