全文获取类型
收费全文 | 74篇 |
免费 | 8篇 |
出版年
2022年 | 1篇 |
2021年 | 1篇 |
2020年 | 1篇 |
2019年 | 1篇 |
2018年 | 1篇 |
2016年 | 1篇 |
2015年 | 3篇 |
2014年 | 3篇 |
2013年 | 4篇 |
2012年 | 5篇 |
2011年 | 2篇 |
2010年 | 4篇 |
2009年 | 2篇 |
2008年 | 5篇 |
2007年 | 6篇 |
2006年 | 1篇 |
2005年 | 5篇 |
2004年 | 4篇 |
2003年 | 2篇 |
2002年 | 3篇 |
1999年 | 4篇 |
1998年 | 2篇 |
1996年 | 1篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1964年 | 1篇 |
排序方式: 共有82条查询结果,搜索用时 31 毫秒
71.
72.
P.J. Weekes 《New Zealand journal of zoology.》2013,40(4):451-460
Abstract A cross-referenced list is provided of 94 helminth taxa, at the generic or specific level, from 61 bird host species in the New Zealand subregion. 相似文献
73.
R I Richardson T E Weekes 《Comparative biochemistry and physiology. A, Comparative physiology》1982,73(3):389-393
1. Glucagon tolbutamide, either alone or in combination, were injected i.v. into pigs and the effect upon plasma glucose and insulin concentrations measured. 2. Glucagon gave similar insulin responses to those seen in humans, but insulin responses to tolbutamide were less than in humans. 3. Combined doses of glucagon and tolbutamide gave similar, though reduced, responses to those seen in humans. At the highest combined doses applied, glucose concentration remained reduced for up to 6 hr. The insulin responses were approximately equal to the sum of the responses to each substance given alone. 相似文献
74.
75.
P. J. Weekes 《New Zealand journal of zoology.》2013,40(3):387-390
Abstract Pulluterina nestoris Smithers is recorded from a wild kea, Nestor notabilis Gould (Aves: Psittaciformes), in New Zealand for the first time. The hitherto unknown scolex is described, and confirms the position of P. nestoris in the Anoplocephalidae. Details of proglottid morphology are discussed, and an amended generic diagnosis is given. 相似文献
76.
The carcinogen dimethylnitrosamine (DMNA) is known to exhibit a high degree of strain, organ, age, and sex related tumor specificity in mice. Using microbial mutagenesis assays coupled with mouse tissue microsomal enzyme activation systems, evidence has been obtained that demonstrated a close relationship between the level of in vitro DMNA activation to a mutagen and in vivo tumor susceptibility. DMNA activation by liver, lung, and kidney microsomes from several mouse strains was compared by measuring the rate of mutagenic metabolites formed during incubation of the carcinogen in mutation assays using Salmonella typhimurium G-46 as the indicator microorganism. 相似文献
77.
78.
Plerocercoids of the tapeworm Ligula intestinalis are reported from a salmonid, Salmo gairdneri , and an eleotrid, Gobiomorphus cotidianus , in New Zealand for the first time. There was no significant difference in condition factors between infected and uninfected trout. The prevalence of infection in bullies sampled increased with total length. 相似文献
79.
80.
Faik N. Musayev Martino L. Di Salvo Mario A. Saavedra Roberto Contestabile Mohini S. Ghatge Alexina Haynes Verne Schirch Martin K. Safo 《The Journal of biological chemistry》2009,284(45):30949-30956
Mutations in pyridoxine 5′-phosphate oxidase are known to cause neonatal epileptic encephalopathy. This disorder has no cure or effective treatment and is often fatal. Pyridoxine 5′-phosphate oxidase catalyzes the oxidation of pyridoxine 5′-phosphate to pyridoxal 5′-phosphate, the active cofactor form of vitamin B6 required by more than 140 different catalytic activities, including enzymes involved in amino acid metabolism and biosynthesis of neurotransmitters. Our aim is to elucidate the mechanism by which a homozygous missense mutation (R229W) in the oxidase, linked to neonatal epileptic encephalopathy, leads to reduced oxidase activity. The R229W variant is ∼850-fold less efficient than the wild-type enzyme due to an ∼192-fold decrease in pyridoxine 5′-phosphate affinity and an ∼4.5-fold decrease in catalytic activity. There is also an ∼50-fold reduction in the affinity of the R229W variant for the FMN cofactor. A 2.5 Å crystal structure of the R229W variant shows that the substitution of Arg-229 at the FMN binding site has led to a loss of hydrogen-bond and/or salt-bridge interactions between FMN and Arg-229 and Ser-175. Additionally, the mutation has led to an alteration of the configuration of a β-strand-loop-β-strand structure at the active site, resulting in loss of two critical hydrogen-bond interactions involving residues His-227 and Arg-225, which are important for substrate binding and orientation for catalysis. These results provide a molecular basis for the phenotype associated with the R229W mutation, as well as providing a foundation for understanding the pathophysiological consequences of pyridoxine 5′-phosphate oxidase mutations. 相似文献