排序方式: 共有227条查询结果,搜索用时 15 毫秒
221.
222.
Yann Deleye Alexia Karen Cotte Sarah Anissa Hannou Nathalie Hennuyer Lucie Bernard Bruno Derudas Sandrine Caron Vanessa Legry Emmanuelle Vallez Emilie Dorchies Nathalie Martin Steve Lancel Jean Sbastien Annicotte Kadiombo Bantubungi Albin Pourtier Violeta Raverdy Franois Pattou Philippe Lefebvre Corinne Abbadie Bart Staels Joel T. Haas Rjane Paumelle 《The Journal of biological chemistry》2020,295(50):17310
223.
224.
Alessandra Battaglia Alexia Buzzonetti Cinzia Baranello Gabriella Ferrandina Enrica Martinelli Francesco Fanfani Giovanni Scambia Andrea Fattorossi 《Cancer immunology, immunotherapy : CII》2009,58(9):1363-1373
Objective We compared the immune system state in metastatic tumour draining lymph nodes (mTDLN) and metastasis free TDLN (mfTDLN) in
53 early stage cervical cancer patients to assess whether the presence of metastatic tumour cells worsen the balance between
an efficacious anti-tumour and a tolerogenic microenvironment.
Methods The immune system state was measured by immunophenotypic and functional assessment of suppressor and effector immune cell
subsets.
Results Compared to mfTDLN, mTDLN were significantly enriched in CD4+Foxp3+ regulatory T cells (Treg), which, in addition, exhibited an activated phenotype (HLA-DR+ and CD69+). Treg in mTDLN were also significantly enriched in neuropilin-1 (Nrp1) expressing cells, a subset particularly potent in
dampening T cell responses. mTDLN tended to be enriched in a population of CD8+Foxp3+T cells (operationally defined as CD8+Treg) that showed a suppressor potency similar to Treg under the same experimental conditions. Plasmacytoid dendritic cells
(pDC) and myeloid DC (mDC) generally show distinct roles in inducing T cell tolerance and activation, respectively. In line
with the excess of suppressor T cells, the ratio pDC to mDC was significantly increased in mTDLN. Immunohistochemical testing
showed that metastatic tumour cells produced the vascular endothelial growth factor, a natural ligand for Nrp1 expressed on
the cell surface of Nrp1+Treg and pDC, and therefore a potential mediator by which tumour cells foster immune privilege in mTDLN. Consistent with the
overall tolerogenic profile, mTDLN showed a significant Tc2 polarisation and tended to contain lower numbers of CD45RA+CD27− effector memory CD8+T cells.
Conclusions The increased recruitment of suppressor type cells concomitant with the scarcity of cytotoxic type cells suggests that in
mTDLN the presence of tumour cells could tip the balance against anti-tumour immune response facilitating the survival of
metastatic tumour cells and possibly contributing to systemic tolerance. 相似文献
225.
Ashley Castellanos-Jankiewicz Omar Guzmán-Quevedo Valérie S. Fénelon Philippe Zizzari Carmelo Quarta Luigi Bellocchio Anne Tailleux Julie Charton Daniela Fernandois Marcus Henricsson Catherine Piveteau Vincent Simon Camille Allard Sandrine Quemener Valentine Guinot Nathalie Hennuyer Alessia Perino Alexia Duveau Daniela Cota 《Cell metabolism》2021,33(7):1483-1492.e10
- Download : Download high-res image (167KB)
- Download : Download full-size image
226.
227.
Plant species richness and environmental heterogeneity in a mountain landscape: effects of variability and spatial configuration 总被引:6,自引:0,他引:6
Alexia Dufour Fawziah Gadallah Helene H. Wagner Antoine Guisan Alexandre Buttler 《Ecography》2006,29(4):573-584
The loss of biodiversity has become a matter of urgent concern and a better understanding of local drivers is crucial for conservation. Although environmental heterogeneity is recognized as an important determinant of biodiversity, this has rarely been tested using field data at management scale. We propose and provide evidence for the simple hypothesis that local species diversity is related to spatial environmental heterogeneity. Species partition the environment into habitats. Biodiversity is therefore expected to be influenced by two aspects of spatial heterogeneity: 1) the variability of environmental conditions, which will affect the number of types of habitat, and 2) the spatial configuration of habitats, which will affect the rates of ecological processes, such as dispersal or competition. Earlier, simulation experiments predicted that both aspects of heterogeneity will influence plant species richness at a particular site. For the first time, these predictions were tested for plant communities using field data, which we collected in a wooded pasture in the Swiss Jura mountains using a four-level hierarchical sampling design. Richness generally increased with increasing environmental variability and "roughness" (i.e. decreasing spatial aggregation). Effects occurred at all scales, but the nature of the effect changed with scale, suggesting a change in the underlying mechanisms, which will need to be taken into account if scaling up to larger landscapes. Although we found significant effects of environmental heterogeneity, other factors such as history could also be important determinants. If a relationship between environmental heterogeneity and species richness can be shown to be general, recently available high-resolution environmental data can be used to complement the assessment of patterns of local richness and improve the prediction of the effects of land use change based on mean site conditions or land use history. 相似文献