全文获取类型
收费全文 | 4840篇 |
免费 | 379篇 |
国内免费 | 1篇 |
出版年
2024年 | 4篇 |
2023年 | 30篇 |
2022年 | 70篇 |
2021年 | 176篇 |
2020年 | 108篇 |
2019年 | 145篇 |
2018年 | 145篇 |
2017年 | 143篇 |
2016年 | 209篇 |
2015年 | 312篇 |
2014年 | 306篇 |
2013年 | 364篇 |
2012年 | 425篇 |
2011年 | 426篇 |
2010年 | 243篇 |
2009年 | 228篇 |
2008年 | 274篇 |
2007年 | 285篇 |
2006年 | 265篇 |
2005年 | 228篇 |
2004年 | 187篇 |
2003年 | 165篇 |
2002年 | 148篇 |
2001年 | 38篇 |
2000年 | 26篇 |
1999年 | 36篇 |
1998年 | 36篇 |
1997年 | 7篇 |
1996年 | 12篇 |
1995年 | 7篇 |
1994年 | 12篇 |
1993年 | 6篇 |
1992年 | 13篇 |
1991年 | 17篇 |
1990年 | 7篇 |
1989年 | 10篇 |
1988年 | 9篇 |
1987年 | 8篇 |
1986年 | 11篇 |
1985年 | 6篇 |
1984年 | 8篇 |
1982年 | 9篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1977年 | 3篇 |
1975年 | 7篇 |
1974年 | 6篇 |
1971年 | 6篇 |
1970年 | 3篇 |
排序方式: 共有5220条查询结果,搜索用时 243 毫秒
141.
Vera Lucia Portal Melissa Medeiros Markoski Alexandre Schaan de Quadros Sílvia Garofallo Julia Lorenzon dos Santos Aline Oliveira Camila Wechenfelder Viviane Paiva de Campos Priscilla Azambuja Lopes de Souza Luana Machado Aline Marcadenti 《Trials》2016,17(1)
BackgroundCardiovascular disease has become a major health problem, and it has been associated with both environmental and genetic factors. Studies have shown that the Mediterranean Diet (MeDiet), or its components such as nuts and olive oil, may be strongly associated with the improvement of cardiovascular risk factors in specific populations. The purpose of the GENUTRI study is to investigate the interaction of genetics with cardiovascular risk factors in a non-Mediterranean population with coronary artery disease (CAD) according to three different diets: rich in pecan nuts, in extra-virgin olive oil or a control diet.Methods/designThe GENUTRI study is a single-center, randomized, open-label, parallel-group, 12-week pragmatic clinical trial conducted in patients aged 40 to 80 years and diagnosed with CAD. A standardized questionnaire will be applied to data collection and a blood sample will be obtained for lipid, glycemic and inflammatory profile evaluation. Polymorphisms in the CD36 and STAT3 genes will be detected using the TaqMan® SNP Genotyping Assay. Patients will be allocated in three groups: group 1: 30 g/day of pecan nuts; group 2: 30 ml/day of olive oil; and group 3: control diet. The primary outcome will consist of changes in LDL-cholesterol (in mg/dl) after 12 weeks of intervention.DiscussionStudies have shown the beneficial effects of diets rich in nuts and olive oil mainly in the Mediterranean population. GENUTRI is a clinical trial focusing on the effects of nuts or olive oil supplementation in Brazilian individuals. Additionally, we will try to demonstrate that genetic polymorphisms linked to cardiovascular disease may modulate the effects of different diets on biochemical and inflammatory markers among these subjects.
Trial registration
ClinicalTrials.gov Identifier: (registered on 18 July 2014: first version). NCT02202265相似文献142.
143.
David Ingram Christoph Engelhardt Alain Farron Alexandre Terrier Philippe Müllhaupt 《Computer methods in biomechanics and biomedical engineering》2016,19(4):450-463
Modelling the shoulder's musculature is challenging given its mechanical and geometric complexity. The use of the ideal fibre model to represent a muscle's line of action cannot always faithfully represent the mechanical effect of each muscle, leading to considerable differences between model-estimated and in vivo measured muscle activity. While the musculo–tendon force coordination problem has been extensively analysed in terms of the cost function, only few works have investigated the existence and sensitivity of solutions to fibre topology. The goal of this paper is to present an analysis of the solution set using the concepts of torque-feasible space (TFS) and wrench-feasible space (WFS) from cable-driven robotics. A shoulder model is presented and a simple musculo–tendon force coordination problem is defined. The ideal fibre model for representing muscles is reviewed and the TFS and WFS are defined, leading to the necessary and sufficient conditions for the existence of a solution. The shoulder model's TFS is analysed to explain the lack of anterior deltoid (DLTa) activity. Based on the analysis, a modification of the model's muscle fibre geometry is proposed. The performance with and without the modification is assessed by solving the musculo–tendon force coordination problem for quasi-static abduction in the scapular plane. After the proposed modification, the DLTa reaches 20% of activation. 相似文献
144.
Genaro Pimienta Douglas M. Heithoff Alexandre Rosa‐Campos Minerva Tran Jeffrey D. Esko Michael J. Mahan Jamey D. Marth Jeffrey W. Smith 《Proteomics》2019,19(5)
Sepsis is an extreme host response to infection that leads to loss of organ function and cardiovascular integrity. Mortality from sepsis is on the rise. Despite more than three decades of research and clinical trials, specific diagnostic and therapeutic strategies for sepsis are still absent. The use of LFQ‐ and TMT‐based quantitative proteomics is reported here to study the plasma proteome in five mouse models of sepsis. A knowledge‐based interpretation of the data reveals a protein network with extensive connectivity through documented functional or physical interactions. The individual proteins in the network all have a documented role in sepsis and are known to be extracellular. The changes in protein abundance observed in the mouse models of sepsis have for the most part the same directionality (increased or decreased abundance) as reported in the literature for human sepsis. This network has been named the Plasma Proteome Signature of Sepsis (PPSS). The PPSS is a quantifiable molecular readout that can supplant the current symptom‐based approach used to diagnose sepsis. This type of molecular interpretation of sepsis, its progression, and its response to therapeutic intervention are an important step in advancing our understanding of sepsis, and for discovering and evaluating new therapeutic strategies. 相似文献
145.
146.
Qiao Huang Kostiantyn Turcheniuk Xiaolei Ren Alexandre Magasinski Daniel Gordon Nasr Bensalah Gleb Yushin 《Liver Transplantation》2019,9(17)
As an alternative to commercial Ni‐ and Co‐based intercalation‐type cathode materials, conversion‐type metal fluoride (MFx) cathodes are attracting more interest due to their promises to increase cell‐level energy density when coupled with lithium (Li) or silicon (Si)‐based anodes. Among metal fluorides, iron fluorides (FeF2 and FeF3) are regarded as some of the most promising candidates due to their high capacity, moderately high potential and the very low cost of Fe. In this study, the impacts of electrolyte composition on the performance and stability of nanostructured FeF2 cathodes are systematically investigated. Dramatic impacts of Li salt composition, Li salt concentration, solvent composition, and cycling potential range on the cathode's most critical performance parameters—stability, capacity, rate, and voltage hysteresis are discovered. In contrast to previous beliefs, it is observed that even if the Fe2+ cation dissolution could be avoided, the dissolution of F? anions may still negatively affect cathode performance. Formation of the more favorable cathode solid electrolyte interface (CEI) is found to minimize both processes. 相似文献
147.
Nihal Kenawy Helen Kalirai Joseph J. Sacco Sarah L. Lake Steffen Heegaard Ann‐Cathrine Larsen Paul T. Finger Tatyana Milman Kimberly Chin Carlo Mosci Francesco Lanza Alexandre Moulin Caroline A. Schmitt Jean Pierre Caujolle Clia Maschi Marina Marinkovic Azzam F. Taktak Heinrich Heimann Bertil E. Damato Sarah E. Coupland 《Pigment cell & melanoma research》2019,32(4):564-575
Relatively little is known about the genetic aberrations of conjunctival melanomas (CoM) and their correlation with clinical and histomorphological features as well as prognosis. The aim of this large collaborative multicenter study was to determine potential key biomarkers for metastatic risk and any druggable targets for high metastatic risk CoM. Using Affymetrix single nucleotide polymorphism genotyping arrays on 59 CoM, we detected frequent amplifications on chromosome (chr) 6p and deletions on 7q, and characterized mutation‐specific copy number alterations. Deletions on chr 10q11.21‐26.2, a region harboring the tumor suppressor genes, PDCD4, SUFU, NEURL1, PTEN, RASSF4, DMBT1, and C10orf90 and C10orf99, significantly correlated with metastasis (Fisher's exact, p ≤ 0.04), lymphatic invasion (Fisher's exact, p ≤ 0.02), increasing tumor thickness (Mann–Whitney, p ≤ 0.02), and BRAF mutation (Fisher's exact, p ≤ 0.05). This enhanced insight into CoM biology is a step toward identifying patients at risk of metastasis and potential therapeutic targets for systemic disease. 相似文献
148.
Soeth Marcelo Fávaro Luis Fernando Spach Henry Louis Daros Felippe Alexandre Woltrich Ana Emília Correia Alberto Teodorico 《Ichthyological Research》2019,66(1):140-154
Ichthyological Research - This is the first study to investigate the age, growth and reproductive biology of the Atlantic spadefish Chaetodipterus faber in southern Brazil. A total of 625... 相似文献
149.
150.
Craveur Pierrick Narwani Tarun J. Rebehmed Joseph de Brevern Alexandre G. 《Amino acids》2019,51(7):1065-1079
Amino Acids - Post-translational modifications (PTMs) are known to play a critical role in the regulation of protein functions. Their impact on protein structures and their link to disorder regions... 相似文献