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N. A. Danilov N. Yu. Ignatieva E. N. Iomdina L. L. Arutyunyan T. E. Grokhovskaya V. V. Lunin 《Biophysics》2011,56(3):490-495
It has been shown that the collagen content and denaturation temperature in scleral tissue increase during the development
of glaucoma whereas the fluorescence intensity does not change. These effects may be related to the disturbance of collagen
catabolism. 相似文献
374.
Stepan G. Romanov Igor V. Ivanov Valery P. Shevchenko Igor Yu. Nagaev Alexandr A. Pushkov Nikolai F. Myasoedov Galina I. Myagkova Hartmut Kuhn 《Chemistry and physics of lipids》2004,130(2):693
Total synthesis of (5Z,8Z,11Z,14Z)-18- and 19-azidoeicosa-5,8,11,14-tetraenoic acids and their [5,6,8,9,11,12,14,15-3H8]-analogues via the corresponding p-toluenesulphonates is reported. This synthetic approach allows the preparation of radioactively labelled arachidonic acid derivatives following a common synthetic route. Activity assays indicated that 15-lipoxygenases may tolerate the azido group in the substrate binding pocket and thus, radioactively labelled azido compounds may be used as photo-affinity probes to investigate mechanistic features of eicosanoid biosynthesis. 相似文献
375.
Herman Ehrlich Yury N. Elkin Alexandr A. Artoukov Valentin A. Stonik Peter P. Safronov Vasily V. Bazhenov Denis V. Kurek Valery P. Varlamov Ren�� Born Heike Meissner Gert Richter 《Marine biotechnology (New York, N.Y.)》2011,13(3):402-410
Unique skeletal formations of marine invertebrates, including representatives of Echinodermata, have the unique potential to serve as templates for bio-inspired materials chemistry, biomimetics, and materials science. The sand dollar Scaphechinus mirabilis (Agassiz, 1983) is widely distributed in the northwest of the Pacific Ocean from southern Japan to the Aleutian Islands. This animal is the main source of naphtochinone-based substances. These compounds have recently drawn medical attention for their use as cardiological and ophthalmological drugs. Unfortunately, after extraction of the naphtochinones, the residual skeletons and spines of the sand dollars were usually discarded. Here, we report the first method for the preparation of nanostructurally organized spines of S. mirabilis, using a simple enzymatic and hydrogen peroxide-based treatment. Application of this method opens the way for development of non-wasteful environmentally clean technology of sand dollars as well-known industrial marine invertebrates. 相似文献
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