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61.
Pewowaruk Ryan Roldán-Alzate Alejandro 《Biomechanics and modeling in mechanobiology》2021,20(5):1659-1674
Biomechanics and Modeling in Mechanobiology - A distributed lumped parameter (DLP) model of blood flow was recently developed that can be simulated in minutes while still incorporating complex... 相似文献
62.
Jesús Alejandro Zamora-Briseo Alejandro Pereira-Santana Sandi Julissa Reyes-Hernndez Daniel Cerqueda-García Enrique Castao Luis Carlos Rodríguez-Zapata 《Cell stress & chaperones》2021,26(1):141
Intrinsic protein disorder is an interesting structural feature where fully functional proteins lack a three-dimensional structure in solution. In this work, we estimated the relative content of intrinsic protein disorder in 96 plant proteomes including monocots and eudicots. In this analysis, we found variation in the relative abundance of intrinsic protein disorder among these major clades; the relative level of disorder is higher in monocots than eudicots. In turn, there is an inverse relationship between the degree of intrinsic protein disorder and protein length, with smaller proteins being more disordered. The relative abundance of amino acids depends on intrinsic disorder and also varies among clades. Within the nucleus, intrinsically disordered proteins are more abundant than ordered proteins. Intrinsically disordered proteins are specialized in regulatory functions, nucleic acid binding, RNA processing, and in response to environmental stimuli. The implications of this on plants’ responses to their environment are discussed. 相似文献
63.
Cluster Computing - This paper proposes a new version of the power of two choices, SQ(d), load balancing algorithm. This new algorithm improves the performance of the classical model based on the... 相似文献
64.
Alejandro Ramirez Garcia Jianbo Zhang Anna Greppi Florentin Constancias Esther Wortmann Muriel Wandres Katherine Hurley Alberto Pascual-García Hans-Joachim Ruscheweyh Shana J. Sturla Christophe Lacroix Clarissa Schwab 《Environmental microbiology》2021,23(3):1765-1779
Glycerol/diol dehydratases (GDH) are enzymes that catalyse the production of propionate from 1,2-propanediol, and acrolein from glycerol. Acrolein reacts with dietary carcinogenic heterocyclic amines (HCA), reducing HCA mutagenicity, but is itself also an antimicrobial agent and toxicant. Gut microbial GDH activity has been suggested as an endogenous acrolein source; however, there is limited information on the potential of the intestinal microbiota to have GDH activity, and what impact it can have on the intestinal ecosystem and host health. We hypothesized that GDH activity of gut microbiota is determined by the abundance and distribution of GDH-active taxa and can be enhanced by supplementation of the GDH active Anaerobutyricum hallii, and tested this hypothesis combining quantitative profiling of gdh, model batch fermentations, microbiota manipulation, and kinetic modelling of acrolein formation. Our results suggest that GDH activity is a common trait of intestinal microbiota shared by a few taxa, which was dependent on overall gdh abundance. Anaerobutyricum hallii was identified as a key taxon in GDH metabolism, and its supplementation increased the rate of GDH activity and acrolein release, which enhanced the transformation of HCA and reduced fermentation activity. The findings of this first systematic study on acrolein release by intestinal microbiota indicate that dietary and microbial modulation might impact GDH activity, which may influence host health. 相似文献
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Ibarra-López Alejandro Ojeda-Zacarías Ma. del Carmen Lozoya-Saldaña Héctor Vázquez-Alvarado Rigoberto E. Olivares-Sáenz Emilio Treviño-Ramírez José E. 《In vitro cellular & developmental biology. Plant》2021,57(6):942-953
In Vitro Cellular & Developmental Biology - Plant - Texas ebony (Ebenopsis ebano [Berland.] Barneby & J.W. Grimes) is a member of the Fabaceae that is native to Mexico. Its wood has... 相似文献
67.
Woyneshet Gelaye Nana Aba Williams Stella Kepha Augusto Messa Junior Pedro Emanuel Fleitas Helena Marti-Soler Destaw Damtie Sissay Menkir Alejandro J. Krolewiecki Lisette van Lieshout Wendemagegn Enbiale 《PLoS neglected tropical diseases》2021,15(2)
BackgroundSoil-transmitted helminths (STH) are common in low and middle income countries where there is lack of access to clean water and sanitation. Effective diagnosis and treatment are essential for the control of STH infections. However, among STH parasites, Strongyloides stercoralis is the most neglected species, both in diagnostics and control strategies. Diagnostic methods cover different approaches, each with different sensitivities and specificities, such as serology, molecular techniques and microscopy based techniques. Of the later, the Baermann technique is the most commonly used procedure. In the literature, several ways have been described to perform the Baermann method, which illustrates the overall lack of a ‘(gold) reference standard’ method for the diagnosis of S. stercoralis infection. In this study we have evaluated the performance of three Baermann techniques in order to improve the reference standard for the microscopic diagnosis of S. stercoralis infection thereby facilitating individual case detection, mapping of the disease and proper evaluation of treatment responses.Methods/Principal findingsA community based cross sectional study was conducted at Zenzelima, Bahir Dar Zuria Ethiopia. A total of 437 stool samples were collected and analyzed by the following procedures: conventional Baermann (CB), modified Baermann (MB), and modified Baermann with charcoal pre-incubation (MBCI). The diagnostic sensitivity and Negative Predictive Value (NPV) of each technique was calculated using the combination of all the three techniques as a composite reference standard. Our result indicated that larvae of S. stercoralis were detected in 151 (34.6%) stool samples. The prevalence of S. stercoralis infection based on the three diagnostic methods was 9.6%, 8.0%, and 31.3% by CB, MB, and MBCI respectively. The sensitivity and NPV for CB, MB, and MBCI were 26.7% and 70.8%, 22.1% and 69.6%, and 87.0% and 93.2%, respectively. The MBCI showed significant difference (P- value = <0.001) in the sensitivity and NPV values when compared with CB and MB values. The agreement between CB, MB, and MBCI with the composite reference standard was 31.8%, 26.7%, 89.6%, respectively.Conclusion/SignificanceOur results suggest the superior performance of MBCI. It is relatively easy to implement, simple to perform and comparatively cheaper. The CB is by far the commonly used method in routine diagnostic although this technique significantly underestimates the true burden of the disease and thereby contributing to the exclusion of S. stercoralis from the control strategies. Therefore, MBCI is recommended as a routine microscopy-based diagnostic test for S. stercoralis infection, particularly in settings where molecular procedures are not available. 相似文献
68.
Alejandro Zarate‐Villafranco Sofía Ortega‐García 《Marine and Freshwater Behaviour and Physiology》2013,45(1):53-72
An analysis of the catch associated with floating objects by the Mexican tuna purse‐seine fleet in the eastern Pacific Ocean during 1992–1993 was made to determine the spatial and seasonal distribution. The information used was generated by observers of the Programa Nacional de Aprovechamiento del Atun y Protección a los Delfines (PNAAPD). There was no clear seasonal and spatial distribution of floating objects examined in this study, however there were areas where floating objects were more common; the mouth of the Gulf of California, waters offshore Peru, and in oceanic waters. The largest catch of yellowfin tuna was offshore of Peru in winter. Two areas with largest (length) yellowfin tuna were the mouth of the Gulf of California and offshore Peru. For skipjack tuna, the largest catch was offshore Peru in winter, but the largest skipjack were caught between 120° and 130°W along 10°N in spring. The largest yellowfin tuna were captured by sets on bamboo, fish aggregating devices (FADs), planks and boards, and logs (trees or parts). The largest skipjack were captured by sets on dead whales, kelp paddies, planks and boards, and pallets and crates. Most of the sets were made during the early hours of the day but an important number of log sets were made in the early afternoon. For the period analyzed, floating objects were more frequent during fall and winter with the area offshore of Peru the most important. 相似文献
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Chamaida Plasencia Dora Pascual-Salcedo Sara García-Carazo Leticia Lojo Laura Nu?o Alejandro Villalba Diana Peiteado Florencia Arribas Jesus Díez Maria Teresa López-Casla Emilio Martín-Mola Alejandro Balsa 《Arthritis research & therapy》2013,15(4):R79