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201.
Effect of aluminum and other multivalent cations on neurofilaments in vitro: an electron microscopic study 总被引:2,自引:0,他引:2
Using electron microscopy (EM) of negatively stained samples, we have systematically explored the effect of aluminum and other multivalent cations on neurofilaments (NFs) in vitro. Interactions of these cations were investigated with bovine, rabbit, and rat spinal cord native NFs, and with 10-nm filaments reconstituted from the 68-kDa subunit (NF-L) isolated from bovine spinal cord. Our results indicated that, as has been observed with other classes of intermediate filaments (IFs), all multivalent cations caused significant aggregation of native NFs, suggesting that this phenomenon is a rather general one and not limited to aluminum. In addition, all cations tried caused significant lateral aggregation of filaments reconstituted from NF-L. Aluminum lactate had an identical effect on bovine, rabbit, and rat NFs. Because aluminum causes strong aggregation of NFs in vitro, a similar phenomenon may occur in vivo leading to the observed accumulation of NFs in neuronal perikarya of rabbits after intoxication with aluminum. These in vitro observations support the concept that some human neurological diseases characterized by the accumulation of NFs may be related to abnormal levels of multivalent cations. 相似文献
202.
Lima Alexandre Bastos Fernandes Sobral Gisela Martins Gabriela Siqueira Pissinatti Alcides Viau Priscila de Oliveira Claudio Alvarenga 《International journal of primatology》2021,42(5):781-801
International Journal of Primatology - The Convention on Biological Diversity and the International Union for Conservation of Nature emphasize that ex situ conservation efforts are unavoidable.... 相似文献
203.
204.
Although frequent studies have been made on the benthos assemblages living in the Southern Ocean, few studies have dealt with
molluscan assemblages and ecology. During the research programmes BENTART carried out in austral summers of 2003 and 2006
in a study area including Low Island, West Antarctic Peninsula, Bellingshausen Sea and Peter I Island, 45 stations were sampled
using quantitative box-corer, Agassiz trawl, epibenthic sledge and rock dredge, at depths of 53–3,304 m. These data were used
to search and analyse the malacological assemblages. A total of 2,889 living specimens of molluscs belonging to 139 species
of shelled Gastropoda, Bivalvia and Scaphopoda were recoded. Gastropods were the best-represented in species richness, but
the bivalves accounted the major abundance and Cyamiocardium denticulatum (460 individuals) was the most abundant species. Species richness varied from 1 to 37 species and diversity showed great
variations at different stations. Four groups of stations of low similarities and some differences in faunistic composition
were observed: one that gathers the Antarctic Peninsula and Peter I Island, one that also includes the Low Island, and two
composed by stations of Bellingshausen Sea. 相似文献
205.
SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F 下载免费PDF全文
Hannah K Shorrock Tao Zu Monica Banez‐Coronel Tammy Reid Hirokazu Furuya H Brent Clark Juan C Troncoso Christopher A Ross SH Subramony Tetsuo Ashizawa Eric T Wang Anthony T Yachnis Laura PW Ranum 《The EMBO journal》2018,37(19)
Spinocerebellar ataxia type 8 (SCA8) is caused by a bidirectionally transcribed CTG·CAG expansion that results in the in vivo accumulation of CUG RNA foci, an ATG‐initiated polyGln and a polyAla protein expressed by repeat‐associated non‐ATG (RAN) translation. Although RAN proteins have been reported in a growing number of diseases, the mechanisms and role of RAN translation in disease are poorly understood. We report a novel toxic SCA8 polySer protein which accumulates in white matter (WM) regions as aggregates that increase with age and disease severity. WM regions with polySer aggregates show demyelination and axonal degeneration in SCA8 human and mouse brains. Additionally, knockdown of the eukaryotic translation initiation factor eIF3F in cells reduces steady‐state levels of SCA8 polySer and other RAN proteins. Taken together, these data show polySer and WM abnormalities contribute to SCA8 and identify eIF3F as a novel modulator of RAN protein accumulation. 相似文献
206.
Hctor N. Seunez Jorge L. Armada Lucy Freitas Roberto Rocha E Silva Alcides Pissinatti Adelmar Coimbra-Filho 《American journal of primatology》1986,10(3):237-247
Chromosome studies in six wild-caught specimens of Cebus apella xanthosternos showed a distinctive chromosome pair number 11 that made it possible to distinguish this subspecies from other Cebus apella. The characteristic chromosome pair had intercalar heterochromatin unlike the “standard” chromosome type of Cebus apella and other species of the same genus, in which this chromosome pair shows a large, terminal, heterochromatic block. A comparison at the chromosomal level between different Cebus apella populations suggests that chromosome 11 in Cebus apella xanthosternos is a derived chromosome that has probably become fixed in this subspecies, either by selection or by drift in a small isolated population. 相似文献
207.
Kim Dong Won Tu Kevin J. Wei Alice Lau Ashley J. Gonzalez-Gil Anabel Cao Tianyu Braunstein Kerstin Ling Jonathan P. Troncoso Juan C. Wong Philip C. Blackshaw Seth Schnaar Ronald L. Li Tong 《Molecular neurodegeneration》2022,17(1):1-3
Drug-refractory forms of neurological diseases could find their next breakthrough therapy in non-pharmacological approaches to brain repair. Lentini et al. present the potential of in situ brain regeneration to address neurodegeneration in the epileptic brain.
相似文献208.
Peracarid crustaceans inhabit many marine benthic habitats and are good indicators of environmental conditions. There is,
however, a lack of information about diversity and distribution of peracarid crustaceans on the shallow subtidal sediments
of the Galician rias. In the summer of 1997, 27 subtidal stations were sampled in the Ría de Aldán, a ria on the southern
margin of the mouth of the Ría de Pontevedra (Galicia, NW Spain). A total of 16,191 peracarid individuals were collected,
comprising 125 species belonging to five orders. Amphipods were dominant in number of species and individuals, followed by
isopods and cumaceans. Multivariate analyses of these data indicated that depth and sediment granulometry were major determinants
of distribution and composition of peracarid assemblages in the ria. 相似文献
209.
Quantitative analysis of macrobenthic soft-bottom assemblages in South Shetland waters (Antarctica) 总被引:4,自引:3,他引:1
J.I. Sáiz-Salinas A. Ramos F.J. García J.S. Troncoso G. San Martin C. Sanz C. Palacin 《Polar Biology》1997,17(4):393-400
Macrobenthic assemblages were investigated at 26 stations located around Livingston Island, Deception Island and the Bransfield
Strait at depths ranging from 42 to 671 m. Representatives of 30 major taxa were found. The maximal density was 5,260 specimens·m−2 at Livingston Island; the mean abundance per station ranged from 160 to 4,380 specimens·m−2. The total biomass of the macrozoobenthos declined with depth, with mean values of 3,201 g·m−2 at shallower depths (< 100 m) and 210 g·m−2 further down (> 100 m). After multivariate analysis (cluster analysis, MDS) based on Bray-Curtis dissimilarities, most stations
could be assigned to one of three groups on the basis of distinct biomass differences between sites. The first cluster with
a rich Ascidiacea biomass is common on shallower bottoms. The second, with Ophiuroidea as a characteristic group, is common
on deeper bottoms. The absence of an ‘indicator’ taxon is characteristic of the remaining cluster of those stations with the
lowest biomass values. No significant correlations were detected between macrobenthic biomass and any sediment parameters
measured, probably because part of the benthos (i.e. the epifauna) could be better explained by the coupling with a highly
productive water column. The role of the epi-infauna sensu Gallardo as the main factor structuring benthic assemblages in
the investigated area is discussed.
Received: 7 March 1996/Accepted: 26 July 1996 相似文献
210.