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381.
Khalid M. Badr El-Din Hesham Salem Sayed Derayea Amany Abdelaziz Dalia M. Nagy 《Luminescence》2023,38(9):1583-1590
A spectrofluorimetric approach that is sensitive, simple, validated, and cost-effective has been proposed for the estimation of amlodipine (AML) and perindopril (PER) in their bulk powders, pharmaceutical formulations, and spiked human plasma. The recommended approach utilized the quantitative quenching effect of the two cited drugs on the fluorescence intensity of erythrosine B, as a result of complex binary reactions among each drug with erythrosine B at pH 3.5 (Teorell and Stenhagen buffer). The quenching of erythrosine B fluorescence was recorded at 554 nm after excitation at 527 nm. The calibration curve was detected in the range 0.25–3.0 μg ml−1, with a correlation coefficient of 0.9996 for AML, and 0.1–1.5 μg ml−1, with a correlation coefficient of 0.9996 for PER. The established spectrofluorimetric approach was validated for the estimation of the cited drugs with high sensitivity regarding International Council on Harmonization guidelines. Therefore, the established approach could be utilized for quality control of the cited drugs in their pharmaceutical formulations. 相似文献
382.
Mohamed Kamel Gellan Alaa Harahsheh Eman Hussein Shaimaa 《Molecular biology reports》2022,49(7):5863-5874
Molecular Biology Reports - Acetaminophen (APAP) is a worldwide antipyretic as well as an analgesic medication. It has been extensively utilized during the outbreak of coronavirus 2019 (COVID-19).... 相似文献
383.
Ali Zainab A. Yasseen Akeel A. McAllister Katherine A. Al-Dujailli Arafat Al-Karaqully Ahmed J. Jumaah Alaa S. 《Molecular biology reports》2022,49(7):6019-6028
Molecular Biology Reports - Autism spectrum disorder (ASD) is an increasing concern among the Iraqi Arab population. The genetic alterations that cause ASD are likely to converge at the synapse.... 相似文献
384.
385.
Saad El-Din H Hassan Somia I Okoued Mahmoud A Mudathir Elfatih M Malik 《Malaria journal》2010,9(1):1-4
Malaria pathogens are transmitted to humans by the bite of female Anopheles mosquitoes. The juvenile stages of these mosquitoes develop in a variety of water bodies and are key targets for vector control campaigns involving the application of larvicides. The effective operational implementation of these campaigns is difficult, time consuming, and expensive. New evidence however, suggests that adult mosquitoes can be co-opted into disseminating larvicides in a far more targeted and efficient manner than can be achieved using conventional methods. 相似文献
386.
The numerous physiological functions of the nonessential amino acid L-aspartate, the semi-essential amino acid L-arginine,
and the essential amino acid L-lysine, made them attractive for a wide range of nutritional and/or therapeutic applications.
Furthermore, the administration of these amino acids as mixtures or as dipeptides for higher bioavailability is scientifically
approved, and various commercial products of these forms are already available on the market. Although the industrial production
of dipeptides is, with few exceptions, in an early stage, several strategies have been established and are compared in this
review. Additionally, the recent developments in the technical production of aspartate–arginine and aspartate–lysine dipeptides
from the biopolymer cyanophycin produced in microorganisms are discussed. Cyanophycin-derived dipeptides are produced exclusively
by biotechnological procedures, probably possess higher bioavailability and may be used as better alternatives to the widely
applied amino acid mixtures. Thus, the pivotal advantages and the potential applications of these dipeptides as well as of
their constituting amino acids in nutrition and therapy are also discussed. Special emphasis is dedicated to arginine due
to its numerous physiological roles in many cardiovascular, genitourinary, gastrointestinal, and immune disorders. 相似文献
387.
The objective of this study was to compare a novel sustained release tablet formulation that has the potential to be used for drugs of different physicochemical properties using a binary mixture of polymethacrylate polymers in their salt forms with the polymethacrylate interpolyelectrolyte complex (IPEC) tablets in terms of drug release and compactness. Also, we aimed to compare this formulation with an IPEC tablet in terms of drug release. Tablets prepared using Eudragit E-Citrate and Eudragit L-Sodium were more convenient, easier to prepare, and showed better sustained release and compactness characteristics compared to IPEC tablets of similar concentrations and preparation methods. 相似文献
388.
Hassan HM Sallam AA Mohammed R Hifnawy MS Youssef DT El Sayed KA 《Bioorganic & medicinal chemistry》2011,19(16):4928-4934
Sarcophine (1) is a bioactive cembranoid diterpene isolated from the Red Sea soft coral Sarcophyton glaucum. Previous semisynthesis attempts resulted in decreased or complete loss of 1's anticancer activity. Sarcophine and analogues showed antimigratory activity against breast and prostate cancer cell lines. This encouraged further semisynthestic optimizations to improve its activity and establish a preliminary structure-activity relationship. Eight new and five known semisynthetic analogues were generated. These compounds were evaluated for their ability to inhibit growth, proliferation, and migration of the prostate and breast metastatic cancer cell lines PC-3 and MDA-MB-231, respectively. Most analogues exhibited enhanced antimigratory activity. 相似文献
389.
El-Sayed MA Abdel-Aziz NI Abdel-Aziz AA El-Azab AS Asiri YA Eltahir KE 《Bioorganic & medicinal chemistry》2011,19(11):3416-3424
New arylhydrazone derivatives and a series of 1,5-diphenyl pyrazoles were designed and synthesized from 1-(4-chlorophenyl)-4,4,4-trifuorobutane-1,3-dione 1. The newly synthesized compounds were investigated in vivo for their anti-inflammatory activities using carrageenan-induced rat paw oedema model. Moreover, they were tested for their inhibitory activity against ovine COX-1 and COX-2 using an in vitro cyclooxygenase (COX) inhibition assay. Some of the new compounds (2f, 6a and 6d) showed a reasonable in vitro COX-2 inhibitory activity, with IC?? value of 0.45 μM and selectivity index of 111.1. A virtual screening was carried out through docking the designed compounds into the COX-2 binding site to predict if these compounds have analogous binding mode to the COX-2 inhibitors. Docking study of the synthesized compounds 2f, 6a and 6d into the active site of COX-2 revealed a similar binding mode to SC-558, a selective COX-2 inhibitor. 相似文献
390.
Bakr Mayada E. Kashef Mona T. Hosny Alaa El-Dien M. S. Ramadan Mohammed A. 《International microbiology》2022,25(3):649-659
International Microbiology - Surface protein display C (SpdC) protein was described as a novel virulence factor of Staphylococcus aureus that affects biofilm formation and pathogenesis and favors... 相似文献